DDX1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDX1_MOUSE
• UniProt AC: Q91VR5
• Protein Name: ATP-dependent RNA helicase DDX1
• Gene Name: Ddx1
• Organism: Mus musculus (Mouse).
• Sequence Length: 740
• Subcellular Localization: Nucleus . Cytoplasm . Cytoplasmic granule . Localized with MBNL1, TIAL1 and YBX1 in stress granules upon stress. Localized with CSTF2 in cleavage bodies. Forms large aggregates called DDX1 bodies. Relocalized into multiple foci (IR-induced foci or IR
• Protein Description: Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation (By similarity). Acts as a positive transcriptional regulator of cyclin CCND2 expression. [PubMed: 19398953 Binds to the cyclin CCND2 promoter region]
• Protein Sequence: MAAFSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLILGGGDVLMAAETGSGKTGAFSIPVIQIVYETLKDQQEGKKGKTTIKTGASVLNKWQMNPYDRGSAFAIGSDGLCCQSREVKEWHGCRGTRGLLKGKHYYEVSCHDQGLCRVGWSTMQASLDLGTDKFGFGFGGTGKKSHNKQFDNYGEEFTMHDTIGCYLDIDKGHVKFSKNGKDLGLAFEIPAHIKNQALFPACVLKNAELKFNFGEEEFKFPPKDGFVALSKAPDNYIVKSQHTGNAQVSQTKFLPNAPKALIVEPSRELAEQTLNNVKQFKKYIDNPKLRELLIIGGVAARDQLSVLDNGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQITCDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKTDKLWERLGKNHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYFMQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVATEKEKVWYHVCSNRGKGCYNTRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQKRAAGGGNYKGHVDVLAPTVQELAALEKEAQTSFLHLGYLPNQLFRTF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
75	Acetylation	LKDQQEGKKGKTTIK HHHHHCCCCCCCEEE	58.56	7969799
80	Phosphorylation	EGKKGKTTIKTGASV CCCCCCCEEECCHHH	24.78	-
117	Acetylation	CCQSREVKEWHGCRG CCCCCCCHHHHCCCC	50.78	23201123
117	Malonylation	CCQSREVKEWHGCRG CCCCCCCHHHHCCCC	50.78	26320211
132	Acetylation	TRGLLKGKHYYEVSC CCCCCCCCEEEEEEE	27.18	22826441
172	Ubiquitination	FGFGGTGKKSHNKQF CCCCCCCCCCCCCCC	51.44	22790023
234	Malonylation	LFPACVLKNAELKFN CCHHHHCCCCEEEEC	33.44	26320211
239	Acetylation	VLKNAELKFNFGEEE HCCCCEEEECCCCCC	29.75	23954790
268	Malonylation	APDNYIVKSQHTGNA CCCCEEEECCCCCCC	34.54	26320211
268	Ubiquitination	APDNYIVKSQHTGNA CCCCEEEECCCCCCC	34.54	-
268	Acetylation	APDNYIVKSQHTGNA CCCCEEEECCCCCCC	34.54	22826441
281	Malonylation	NAQVSQTKFLPNAPK CCEECCCEECCCCCC	36.95	26320211
281	Acetylation	NAQVSQTKFLPNAPK CCEECCCEECCCCCC	36.95	23806337
281	Ubiquitination	NAQVSQTKFLPNAPK CCEECCCEECCCCCC	36.95	-
288	Ubiquitination	KFLPNAPKALIVEPS EECCCCCCEEEECCC	54.11	22790023
346	Phosphorylation	GVDIVVGTPGRLDDL CEEEEECCCCCHHHH	15.80	26745281
358	Ubiquitination	DDLVSTGKLNLSQVR HHHHHCCCCCHHHEE	34.00	22790023
406	S-palmitoylation	KRLQVIVCSATLHSF CEEEEEEEECEECCC	1.25	26165157
436	Phosphorylation	VDLKGEDSVPDTVHH ECCCCCCCCCCCEEE	31.11	22817900
475	Phosphorylation	DVHAKDNTRPGANSP CCCCCCCCCCCCCCH	48.66	27742792
481	Phosphorylation	NTRPGANSPEMWSEA CCCCCCCCHHHHHHH	23.00	25521595
486	Phosphorylation	ANSPEMWSEAIKILK CCCHHHHHHHHHHHC	18.81	27742792
513	S-palmitoylation	MDQAIIFCRTKIDCD CCEEEEEECCEECCC	3.68	28526873
516	Malonylation	AIIFCRTKIDCDNLE EEEEECCEECCCHHH	19.73	26320211
571	S-palmitoylation	GDVRFLICTDVAARG CCEEEEEEECHHHCC	2.64	28526873
628	Phosphorylation	TEKEKVWYHVCSNRG ECHHHEEEEECCCCC	6.33	-
632	Phosphorylation	KVWYHVCSNRGKGCY HEEEEECCCCCCCCC	28.59	23684622
693	Malonylation	GKVTYGQKRAAGGGN CEEEECCCCCCCCCC	39.37	26320211
731	Phosphorylation	TSFLHLGYLPNQLFR HCHHHHCCCHHHHHC	25.91	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DDX1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DDX1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDX1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DDX1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.