HP1B3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HP1B3_MOUSE
• UniProt AC: Q3TEA8
• Protein Name: Heterochromatin protein 1-binding protein 3
• Gene Name: Hp1bp3
• Organism: Mus musculus (Mouse).
• Sequence Length: 554
• Subcellular Localization: Nucleus . Chromosome . localized in nuclei but not in nucleoli in interphase. Colocalized with chromosomes in mitosis, with a gradually increased during G1 progression and a maximum level during late G1 phase (G1/S).
• Protein Description: Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity. May play a role in hypoxia-induced oncogenesis..
• Protein Sequence: MATDMSQGELIHPKALPLIVGAQLIHADKLGEKAEDTTMPIRRAVNSTRETPPKSKLAEGEEEKPEPDGSSEESISTVEEQENETPPATSSEAEQPKGEPESGEKEENNNKSAEEPKKDEKDQSKEKEKKVKKTIPAWATLSASQLARAQRQTPMASSPRPKMDAILTEAIKACFQKTGASVVAIRKYIIHKYPSLGLERRGYLLKQALKRELNRGVIRQVKGKGASGSFVVVQKSKPPQKSKNRKKGSALDPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGANSNYQMHLLKKTLQKCEKNGWLEQISGKGFSGTFQLSFPYYPSPGVLFPKKESGGSDDEDEDDDDDESSEDSEDEEPPPKRSLQKKTPAKSQGKTASMKQRGSKPARKVPAAQRGKVRPLPKKAPPKAKTPARKARPSPSVIKKPSGSSSRKPIASARKEAKLPGKGKSAMKKSFKTKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATDMSQGE ------CCCCCCCCC	16.59	-
3	Phosphorylation	-----MATDMSQGEL -----CCCCCCCCCC	30.82	20531401
6	Phosphorylation	--MATDMSQGELIHP --CCCCCCCCCCCCC	37.53	25266776
14	Acetylation	QGELIHPKALPLIVG CCCCCCCCHHHHHEE	48.68	22826441
29	Acetylation	AQLIHADKLGEKAED EEEEEHHHCCCCCCC	60.21	23236377
37	Phosphorylation	LGEKAEDTTMPIRRA CCCCCCCCCCHHHHH	19.25	22418434
38	Phosphorylation	GEKAEDTTMPIRRAV CCCCCCCCCHHHHHH	33.02	20469934
47	Phosphorylation	PIRRAVNSTRETPPK HHHHHHHCCCCCCCH	23.42	23684622
48	Phosphorylation	IRRAVNSTRETPPKS HHHHHHCCCCCCCHH	27.59	26824392
51	Phosphorylation	AVNSTRETPPKSKLA HHHCCCCCCCHHHCC	41.42	26824392
54	Ubiquitination	STRETPPKSKLAEGE CCCCCCCHHHCCCCC	62.52	27667366
55 (in isoform 2)	Phosphorylation	-	38.38	25266776
55	Phosphorylation	TRETPPKSKLAEGEE CCCCCCHHHCCCCCC	38.38	24453211
67	Ubiquitination	GEEEKPEPDGSSEES CCCCCCCCCCCCHHH	60.84	27667366
70	Phosphorylation	EKPEPDGSSEESIST CCCCCCCCCHHHCCH	41.79	21659605
71	Phosphorylation	KPEPDGSSEESISTV CCCCCCCCHHHCCHH	51.41	25521595
72 (in isoform 2)	Phosphorylation	-	58.42	25521595
74	Phosphorylation	PDGSSEESISTVEEQ CCCCCHHHCCHHHHH	20.14	26643407
76	Phosphorylation	GSSEESISTVEEQEN CCCHHHCCHHHHHCC	35.36	26643407
76 (in isoform 2)	Phosphorylation	-	35.36	27742792
77 (in isoform 2)	Phosphorylation	-	30.21	27742792
77	Phosphorylation	SSEESISTVEEQENE CCHHHCCHHHHHCCC	30.21	25521595
78 (in isoform 2)	Phosphorylation	-	6.43	27742792
82	Ubiquitination	ISTVEEQENETPPAT CCHHHHHCCCCCCCC	61.38	27667366
85	Phosphorylation	VEEQENETPPATSSE HHHHCCCCCCCCCCC	46.27	22802335
89	Phosphorylation	ENETPPATSSEAEQP CCCCCCCCCCCCCCC	38.26	26643407
90	Phosphorylation	NETPPATSSEAEQPK CCCCCCCCCCCCCCC	28.43	26643407
91	Phosphorylation	ETPPATSSEAEQPKG CCCCCCCCCCCCCCC	36.15	26643407
92	Ubiquitination	TPPATSSEAEQPKGE CCCCCCCCCCCCCCC	56.86	27667366
95	Ubiquitination	ATSSEAEQPKGEPES CCCCCCCCCCCCCCC	52.64	27667366
105	Ubiquitination	GEPESGEKEENNNKS CCCCCCCCCCCCCCC	74.07	27667366
112	Phosphorylation	KEENNNKSAEEPKKD CCCCCCCCCCCCCCC	42.93	23375375
119	Ubiquitination	SAEEPKKDEKDQSKE CCCCCCCCHHHHHHH	74.44	27667366
120	Ubiquitination	AEEPKKDEKDQSKEK CCCCCCCHHHHHHHH	68.37	27667366
132	Ubiquitination	KEKEKKVKKTIPAWA HHHHHHHHHHHHHHH	53.75	27667366
133	Ubiquitination	EKEKKVKKTIPAWAT HHHHHHHHHHHHHHH	55.46	27667366
140	Phosphorylation	KTIPAWATLSASQLA HHHHHHHHCCHHHHH	15.56	26643407
142	Phosphorylation	IPAWATLSASQLARA HHHHHHCCHHHHHHH	22.86	26643407
144	Phosphorylation	AWATLSASQLARAQR HHHHCCHHHHHHHHH	23.50	26745281
147	Ubiquitination	TLSASQLARAQRQTP HCCHHHHHHHHHHCC	9.34	27667366
157	Phosphorylation	QRQTPMASSPRPKMD HHHCCCCCCCCHHHH	34.32	25159016
158	Phosphorylation	RQTPMASSPRPKMDA HHCCCCCCCCHHHHH	18.52	26824392
160	Ubiquitination	TPMASSPRPKMDAIL CCCCCCCCHHHHHHH	45.48	27667366
192	Acetylation	IRKYIIHKYPSLGLE EHHHHHHHCCCCCHH	48.74	23806337
227	Phosphorylation	QVKGKGASGSFVVVQ HHCCCCCCCCEEEEE	43.57	28833060
229	Phosphorylation	KGKGASGSFVVVQKS CCCCCCCCEEEEECC	16.63	28833060
249	Phosphorylation	SKNRKKGSALDPEPQ CCCCCCCCCCCCCCC	34.24	28833060
268	Ubiquitination	DVLPLAFTRLCEPKE HHHHHHHHHHCCCHH	19.68	27667366
269	Ubiquitination	VLPLAFTRLCEPKEA HHHHHHHHHCCCHHH	30.78	27667366
274	Acetylation	FTRLCEPKEASYSLI HHHHCCCHHHHHHHH	43.55	22826441
279	Phosphorylation	EPKEASYSLIRKYVS CCHHHHHHHHHHHHH	18.15	29176673
282	Ubiquitination	EASYSLIRKYVSQYY HHHHHHHHHHHHHHC	29.55	27667366
286	Phosphorylation	SLIRKYVSQYYPKLR HHHHHHHHHHCHHHC	14.91	24759943
307	Ubiquitination	LLKNALQRAVERGQL HHHHHHHHHHHHCCH	41.26	27667366
319	Ubiquitination	GQLEQITGKGASGTF CCHHHHCCCCCCCCE	28.20	27667366
320	Ubiquitination	QLEQITGKGASGTFQ CHHHHCCCCCCCCEE	42.53	22790023
323	Phosphorylation	QITGKGASGTFQLKK HHCCCCCCCCEEECC	47.21	29176673
330	Ubiquitination	SGTFQLKKSGEKPLL CCCEEECCCCCCCCC	72.75	-
334	Ubiquitination	QLKKSGEKPLLGGSL EECCCCCCCCCCHHH	44.48	27667366
346	Ubiquitination	GSLMEYAILSAIAAM HHHHHHHHHHHHHHH	2.82	27667366
347	Ubiquitination	SLMEYAILSAIAAMN HHHHHHHHHHHHHHC	1.84	27667366
348	Phosphorylation	LMEYAILSAIAAMNE HHHHHHHHHHHHHCC	16.12	22802335
358	Phosphorylation	AAMNEPKTCSTTALK HHHCCCCCCCHHHHH	23.54	28576409
361	Phosphorylation	NEPKTCSTTALKKYV CCCCCCCHHHHHHHH	20.45	28576409
362	Phosphorylation	EPKTCSTTALKKYVL CCCCCCHHHHHHHHH	17.44	28576409
377	Phosphorylation	ENHPGANSNYQMHLL HCCCCCCCHHHHHHH	36.06	25367039
379	Phosphorylation	HPGANSNYQMHLLKK CCCCCCHHHHHHHHH	13.66	25195567
415	Phosphorylation	TFQLSFPYYPSPGVL EEEEECCCCCCCCEE	26.46	26745281
416	Phosphorylation	FQLSFPYYPSPGVLF EEEECCCCCCCCEEC	9.47	26745281
418	Phosphorylation	LSFPYYPSPGVLFPK EECCCCCCCCEECCC	20.40	26643407
428	Phosphorylation	VLFPKKESGGSDDED EECCCCCCCCCCCCC	58.28	25159016
431	Phosphorylation	PKKESGGSDDEDEDD CCCCCCCCCCCCCCC	45.47	25159016
443	Phosphorylation	EDDDDDESSEDSEDE CCCCCCCCCCCCCCC	46.12	25159016
444	Phosphorylation	DDDDDESSEDSEDEE CCCCCCCCCCCCCCC	43.29	25159016
447	Phosphorylation	DDESSEDSEDEEPPP CCCCCCCCCCCCCCC	42.78	25159016
462	Phosphorylation	KRSLQKKTPAKSQGK CCCCCCCCCCCCCCC	35.20	25266776
469	Acetylation	TPAKSQGKTASMKQR CCCCCCCCCCHHHHC	33.03	23806337
513	Phosphorylation	PARKARPSPSVIKKP CCHHCCCCCCCCCCC	25.01	25521595
515	Phosphorylation	RKARPSPSVIKKPSG HHCCCCCCCCCCCCC	40.59	24068923

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HP1B3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HP1B3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HP1B3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of HP1B3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A differential phosphoproteomic analysis of retinoic acid-treated P19cells.";
Smith J.C., Duchesne M.A., Tozzi P., Ethier M., Figeys D.;
J. Proteome Res. 6:3174-3186(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-431; SER-443; SER-444AND SER-447, AND MASS SPECTROMETRY.
PubMed: 17622165

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-51, AND MASSSPECTROMETRY.
PubMed: 19367708