RPN1_MOUSE - dbPTM
RPN1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RPN1_MOUSE
UniProt AC Q91YQ5
Protein Name Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Gene Name Rpn1
Organism Mus musculus (Mouse).
Sequence Length 608
Subcellular Localization Endoplasmic reticulum . Endoplasmic reticulum membrane
Single-pass type I membrane protein . Melanosome .
Protein Description Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains..
Protein Sequence MESPVALLLLLLLCLGALAPTPGSASSEAPPLVNEDVKRTVDLSSHLAKVTAEVVLVHPGGGSTSRASSFVLALEPELESRLAHLGVQIKGEDEEDNNLEVRETKIKGKSGRFFTVKLPVALDPGSKISVVVETVYTHVLHPYPTQITQSEKQFVVFEGNHYFYSPYPTKTQTMRVKLASRNVESYTKLGNPSRSEDVLDYGPFKDIPAYSQDTFKVHYENNSPFLTITSMTRVIEVSHWGNIAVEENVDLKHTGAVLKGPFSRYDYQRQPDSGISSIRSFKTILPAAAQDVYYRDEIGNVSTSHLLILDDSVEMEIRPRFPLFGGWKTHYIVGYNLPSYEYLYNLGDQYALKMRFVDHVFDEQVIDSLTVKIILPEGAKNIQVDSPYDISRAPDELHYTYLDTFGRPVIVAYKKNLVEQHIQDIVVHYTFNKVLMLQEPLLVVAAFYILFFTVIIYVRLDFSITKDPAAEARMKVACITEQVLTLVNKRLGLYRHFDETVNRYKQSRDISTLNSGKKSLETEHKAVTSEIAVLQSRLKTEGSDLCDRVSEMQKLDAQVKELVLKSAVEAERLVAGKLKKDTYLENEKLSSGKRQELVTKIDHILDAL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
63PhosphorylationLVHPGGGSTSRASSF
EEECCCCCCCHHHHH		26.8728464351
69PhosphorylationGSTSRASSFVLALEP
CCCCHHHHHEEEECH		20.5625338131
117SuccinylationSGRFFTVKLPVALDP
CCCEEEEEEEEEECC		43.9723954790
117AcetylationSGRFFTVKLPVALDP
CCCEEEEEEEEEECC		43.9722826441
188AcetylationRNVESYTKLGNPSRS
CCHHHHHCCCCCCCC		46.2823806337
188SuccinylationRNVESYTKLGNPSRS
CCHHHHHCCCCCCCC		46.2823806337
201PhosphorylationRSEDVLDYGPFKDIP
CCCCCCCCCCCCCCC		23.6523140645
205SuccinylationVLDYGPFKDIPAYSQ
CCCCCCCCCCCCCCC		58.8623954790
273PhosphorylationDYQRQPDSGISSIRS
CCCCCCCCCCCHHHH		44.7128464351
276PhosphorylationRQPDSGISSIRSFKT
CCCCCCCCHHHHHCH		24.2025367039
277PhosphorylationQPDSGISSIRSFKTI
CCCCCCCHHHHHCHH		21.7925367039
300N-linked_GlycosylationYYRDEIGNVSTSHLL
EECCCCCCCCCCEEE		30.17-
414AcetylationRPVIVAYKKNLVEQH
CEEEEEECCCHHHHH		26.00156505
478S-palmitoylationEARMKVACITEQVLT
HHHHHHHHHHHHHHH		4.4128526873
478S-nitrosylationEARMKVACITEQVLT
HHHHHHHHHHHHHHH		4.4122178444
478GlutathionylationEARMKVACITEQVLT
HHHHHHHHHHHHHHH		4.4124333276
489UbiquitinationQVLTLVNKRLGLYRH
HHHHHHHHHHCCHHH		41.33-
515PhosphorylationRDISTLNSGKKSLET
CCHHHHHCCCCCHHH		55.9228066266
517AcetylationISTLNSGKKSLETEH
HHHHHCCCCCHHHHH		38.726568945
519PhosphorylationTLNSGKKSLETEHKA
HHHCCCCCHHHHHHH		34.6226026062
525UbiquitinationKSLETEHKAVTSEIA
CCHHHHHHHHHHHHH		38.02-
525AcetylationKSLETEHKAVTSEIA
CCHHHHHHHHHHHHH		38.0223236377
525MalonylationKSLETEHKAVTSEIA
CCHHHHHHHHHHHHH		38.0226320211
528PhosphorylationETEHKAVTSEIAVLQ
HHHHHHHHHHHHHHH		26.0428066266
529PhosphorylationTEHKAVTSEIAVLQS
HHHHHHHHHHHHHHH		22.0228066266
536PhosphorylationSEIAVLQSRLKTEGS
HHHHHHHHHHHCCCC		35.1128066266
539MalonylationAVLQSRLKTEGSDLC
HHHHHHHHCCCCCHH		43.3426320211
539UbiquitinationAVLQSRLKTEGSDLC
HHHHHHHHCCCCCHH		43.34-
539AcetylationAVLQSRLKTEGSDLC
HHHHHHHHCCCCCHH		43.3423806337
540PhosphorylationVLQSRLKTEGSDLCD
HHHHHHHCCCCCHHH		50.6128066266
543PhosphorylationSRLKTEGSDLCDRVS
HHHHCCCCCHHHHHH		22.6028066266
546GlutathionylationKTEGSDLCDRVSEMQ
HCCCCCHHHHHHHHH		3.6424333276
546S-nitrosylationKTEGSDLCDRVSEMQ
HCCCCCHHHHHHHHH		3.6422178444
546S-palmitoylationKTEGSDLCDRVSEMQ
HCCCCCHHHHHHHHH		3.6428526873
554MalonylationDRVSEMQKLDAQVKE
HHHHHHHHHHHHHHH		47.2026320211
554AcetylationDRVSEMQKLDAQVKE
HHHHHHHHHHHHHHH		47.2023201123
554UbiquitinationDRVSEMQKLDAQVKE
HHHHHHHHHHHHHHH		47.20-
560UbiquitinationQKLDAQVKELVLKSA
HHHHHHHHHHHHHHH		33.00-
560MalonylationQKLDAQVKELVLKSA
HHHHHHHHHHHHHHH		33.0026320211
565MalonylationQVKELVLKSAVEAER
HHHHHHHHHHHHHHH		28.9626320211
565UbiquitinationQVKELVLKSAVEAER
HHHHHHHHHHHHHHH		28.96-
577MalonylationAERLVAGKLKKDTYL
HHHHHCCCCCCCCCC		47.6026320211
579MalonylationRLVAGKLKKDTYLEN
HHHCCCCCCCCCCCC		52.6826320211
579UbiquitinationRLVAGKLKKDTYLEN
HHHCCCCCCCCCCCC		52.68-
580MalonylationLVAGKLKKDTYLENE
HHCCCCCCCCCCCCC		66.7826320211
580UbiquitinationLVAGKLKKDTYLENE
HHCCCCCCCCCCCCC		66.78-
588AcetylationDTYLENEKLSSGKRQ
CCCCCCCCCCCCCCH		66.3123806337
588MalonylationDTYLENEKLSSGKRQ
CCCCCCCCCCCCCCH		66.3126320211
588UbiquitinationDTYLENEKLSSGKRQ
CCCCCCCCCCCCCCH		66.31-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RPN1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RPN1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RPN1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of RPN1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RPN1_MOUSE

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Related Literatures of Post-Translational Modification

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