dbPTM

DDX54_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DDX54_MOUSE
UniProt AC	Q8K4L0
Protein Name	ATP-dependent RNA helicase DDX54
Gene Name	Ddx54
Organism	Mus musculus (Mouse).
Sequence Length	874
Subcellular Localization	Nucleus, nucleolus.
Protein Description	Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors (By similarity)..
Protein Sequence	MAAGRRVGPGPPSRPTMAPWKKKRLRKRRTGASQGRDSDSDDGEFEIQAEDDARARKLGPGRALPSFPTSECVSDVEPDTREMVRAQNKKKKKSGGFQSMGLSYPVFKGIMKKGYKVPTPIQRKTIPVILDGKDVVAMARTGSGKTACFLLPMFERLKARSAQTGARALILSPTRELALQTMKFTKELGKFTGLKTALILGGDKMEDQFAALHENPDIIIATPGRLVHVAVEMNLKLQSVEYVVFDEADRLFEMGFAEQLQEIIGRLPGGHQTVLFSATLPKLLVEFARAGLTEPVLIRLDVDSKLNEQLKTSFLLVREDTKAAVLLYLLQNVVRPQDQTVVFVATKHHAEYLTELLMGQGVSCAHIYSALDQTARKINLAKFTHNKCSTLIVTDLAARGLDIPLLDNVINYSFPAKGKLFLHRVGRVARAGRSGTAYSLVAPDEVPYLLDLHLFLGRSVTLARPCEEPSVADAVGRDGVLGRVPQSVVDDEDSSLQTAMGASLDLQGLHRVANNAQQQYVRSRPAPSPESIKRAKELDLAELGLHPLFSSCFEEGELQRLRLVDSIKNYRTRTTIFEINASSKDPSSQMMRAKRQRDRKAVASFQQRRQERQEGPADPAPQRELPQEEEEEMVETVEGVFTEVVGQKRPRPGPSQGAKRRRMETRQRDQEFYVPYRPKDFDSERGLSVSGAGGAFEQQVAGAVLDLMGDEAQNMSRGQQQLKWDRKKKRFVGQSGQEDKKKIKTESGRFISSSYKRDLYQKWKQKQKIDDRDSEEEGPSNQRGPGPRRGGKRGRSQGTSQPRASSVPAGRMRSELKTKEQILKQRRQAQKQRFLQRGGLKQLSARNRRRAQELRQGAFGRGAPSRKGKMRKRM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	KRLRKRRTGASQGRD HHHHHHCCCCCCCCC	40.93	27087446
33	Phosphorylation	RKRRTGASQGRDSDS HHHCCCCCCCCCCCC	34.22	23684622
38	Phosphorylation	GASQGRDSDSDDGEF CCCCCCCCCCCCCCE	37.34	27087446
40	Phosphorylation	SQGRDSDSDDGEFEI CCCCCCCCCCCCEEE	41.37	27087446
66	Phosphorylation	GPGRALPSFPTSECV CCCCCCCCCCCCHHC	44.71	25619855
69	Phosphorylation	RALPSFPTSECVSDV CCCCCCCCCHHCCCC	34.84	21082442
70	Phosphorylation	ALPSFPTSECVSDVE CCCCCCCCHHCCCCC	29.27	21082442
74	Phosphorylation	FPTSECVSDVEPDTR CCCCHHCCCCCCCHH	47.82	25521595
80	Phosphorylation	VSDVEPDTREMVRAQ CCCCCCCHHHHHHHH	38.96	25619855
190	Acetylation	KFTKELGKFTGLKTA HHHHHHHHHCCCCEE	52.99	6568975
195	Acetylation	LGKFTGLKTALILGG HHHHCCCCEEEEECC	32.85	6569161
528	Phosphorylation	VRSRPAPSPESIKRA HHCCCCCCHHHHHHH	43.32	19854140
566	Phosphorylation	QRLRLVDSIKNYRTR HHHHHHHHHCCCCCC	28.16	29176673
604	Phosphorylation	RDRKAVASFQQRRQE HHHHHHHHHHHHHHH	19.59	29176673
659	Acetylation	PGPSQGAKRRRMETR CCCCCCHHHHHCCHH	53.94	9854559
688	Phosphorylation	FDSERGLSVSGAGGA CCCCCCCCCCCCCHH	19.63	-
690	Phosphorylation	SERGLSVSGAGGAFE CCCCCCCCCCCHHHH	21.39	-
752	Phosphorylation	TESGRFISSSYKRDL CCCCCCCCCHHHHHH	15.54	29176673
753	Phosphorylation	ESGRFISSSYKRDLY CCCCCCCCHHHHHHH	32.63	29176673
754	Phosphorylation	SGRFISSSYKRDLYQ CCCCCCCHHHHHHHH	28.08	29176673
774	Phosphorylation	QKIDDRDSEEEGPSN HCCCCCCCCCCCCCC	48.04	27087446
780	Phosphorylation	DSEEEGPSNQRGPGP CCCCCCCCCCCCCCC	57.35	25619855
805	Phosphorylation	GTSQPRASSVPAGRM CCCCCCHHCCCCHHH	32.90	28066266
806	Phosphorylation	TSQPRASSVPAGRMR CCCCCHHCCCCHHHH	31.00	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DDX54_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DDX54_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DDX54_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DDX54_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DDX54_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-774, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38 AND SER-40, AND MASSSPECTROMETRY.	17242355 [Abstract]