SAP18_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAP18_MOUSE
• UniProt AC: O55128
• Protein Name: Histone deacetylase complex subunit SAP18
• Gene Name: Sap18
• Organism: Mus musculus (Mouse).
• Sequence Length: 153
• Subcellular Localization: Nucleus . Cytoplasm . Nucleus speckle . Shuttles between the nucleus and the cytoplasm (By similarity). Colocalizes with ACIN1 and SRSF2 in nuclear speckles (By similarity).
• Protein Description: Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function (By similarity)..
• Protein Sequence: MAVESRVTQEEIKKEPEKPIDREKTCPLLLRVFTTNNGRHHRMDEFSRGNVPSSELQIYTWMDATLKELTSLVKEVYPEARKKGTHFNFAIVFMDLKRPGYRVKEIGSTMSGRKGTDDSMTLQSQKFQIGDYLDIAITPPNRAPPSSGRMRPY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAVESRVTQ ------CCCCCCCCH	17.49	-
74	Ubiquitination	KELTSLVKEVYPEAR HHHHHHHHHHCHHHH	46.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SAP18_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAP18_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAP18_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SUFU_MOUSE	Sufu	physical	14611647
PIAS1_MOUSE	Pias1	physical	14611647
PININ_HUMAN	PNN	physical	22388736
RNPS1_HUMAN	RNPS1	physical	22388736

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.