SUFU_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SUFU_MOUSE
• UniProt AC: Q9Z0P7
• Protein Name: Suppressor of fused homolog
• Gene Name: Sufu
• Organism: Mus musculus (Mouse).
• Sequence Length: 484
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Negative regulator in the hedgehog/smoothened signaling pathway. [PubMed: 16155214]
• Protein Sequence: MAELRPSVAPGPAAPPASGPSAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDPLDYVSMYRNMGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSENTFCSGDHVSWHSPLDNSESRIQHMLLTEDPQMQPVRTPFGVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWLITDMRRGETIFEIDPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDEEDSRSICLGTQPRRLSGKDTEQIRETLRRGLEINSKPVLPPINSQRQNGLTHDRAPSRKDSLGSDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEKMLEDLEDLTSPEEFKLPKEYSWPEKKLKVSILPDVVFDSPLH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60 (in isoform 2)	Phosphorylation	-	8.58	25168779
63 (in isoform 2)	Phosphorylation	-	31.29	25168779
65 (in isoform 2)	Phosphorylation	-	37.94	25168779
69 (in isoform 2)	Phosphorylation	-	47.37	25168779
76 (in isoform 2)	Phosphorylation	-	22.98	25168779
190	Phosphorylation	PQMQPVRTPFGVVTF CCCCCCCCCCHHHHH	24.17	-
267	Phosphorylation	ETDGSNLSGVSAKCA CCCCCCCCCCCCCCC	41.20	22817900
301	Phosphorylation	GTQPRRLSGKDTEQI CCCCCCCCCCCHHHH	41.82	28507225
303	Acetylation	QPRRLSGKDTEQIRE CCCCCCCCCHHHHHH	59.09	23806337
305	Phosphorylation	RRLSGKDTEQIRETL CCCCCCCHHHHHHHH	33.02	25777480
342	Phosphorylation	LTHDRAPSRKDSLGS CCCCCCCCCCCCCCC	51.48	28507225
346	Phosphorylation	RAPSRKDSLGSDSST CCCCCCCCCCCCCCC	37.35	25521595
349	Phosphorylation	SRKDSLGSDSSTAII CCCCCCCCCCCCEEC	39.34	27742792
351	Phosphorylation	KDSLGSDSSTAIIPH CCCCCCCCCCEECCH	31.14	27742792
352	Phosphorylation	DSLGSDSSTAIIPHE CCCCCCCCCEECCHH	27.18	27742792
353	Phosphorylation	SLGSDSSTAIIPHEL CCCCCCCCEECCHHH	26.31	27742792
452	Phosphorylation	EDLEDLTSPEEFKLP HHHHHCCCHHHHCCC	37.30	25338131
457	Ubiquitination	LTSPEEFKLPKEYSW CCCHHHHCCCCCCCC	68.13	-
481	Phosphorylation	LPDVVFDSPLH---- CCCCCCCCCCC----	20.21	26745281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SUFU_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
257	K	ubiquitylation	Polyubiquitinated at Lys-257 by the SCF(FBXL17) complex, leading to its subsequent degradation and allowing the release of GLI1 for proper hedgehog/smoothened signal transduction.	-
342	S	Phosphorylation	Phosphorylation at Ser-342, Ser-346, Ser-352 and Thr-353 prevents ubiquitination by the SCF(FBXL17) complex.	-
342	S	Phosphorylation	Ubiquitination is impaired by phosphorylation at Ser-342, Ser-346, Ser-352 and Thr-353.	-
342	S	ubiquitylation	Phosphorylation at Ser-342, Ser-346, Ser-352 and Thr-353 prevents ubiquitination by the SCF(FBXL17) complex.	-
342	S	ubiquitylation	Ubiquitination is impaired by phosphorylation at Ser-342, Ser-346, Ser-352 and Thr-353.	-
346	S	ubiquitylation	Ubiquitination is impaired by phosphorylation at Ser-342, Ser-346, Ser-352 and Thr-353.	21183079
346	S	ubiquitylation	Phosphorylation at Ser-342, Ser-346, Ser-352 and Thr-353 prevents ubiquitination by the SCF(FBXL17) complex.	21183079
346	S	Phosphorylation	Ubiquitination is impaired by phosphorylation at Ser-342, Ser-346, Ser-352 and Thr-353.	21183079
346	S	Phosphorylation	Phosphorylation at Ser-342, Ser-346, Ser-352 and Thr-353 prevents ubiquitination by the SCF(FBXL17) complex.	21183079
352	S	Phosphorylation	Phosphorylation at Ser-342, Ser-346, Ser-352 and Thr-353 prevents ubiquitination by the SCF(FBXL17) complex.	-
352	S	Phosphorylation	Ubiquitination is impaired by phosphorylation at Ser-342, Ser-346, Ser-352 and Thr-353.	-
352	S	ubiquitylation	Phosphorylation at Ser-342, Ser-346, Ser-352 and Thr-353 prevents ubiquitination by the SCF(FBXL17) complex.	-
352	S	ubiquitylation	Ubiquitination is impaired by phosphorylation at Ser-342, Ser-346, Ser-352 and Thr-353.	-
353	T	Phosphorylation	Phosphorylation at Ser-342, Ser-346, Ser-352 and Thr-353 prevents ubiquitination by the SCF(FBXL17) complex.	-
353	T	Phosphorylation	Ubiquitination is impaired by phosphorylation at Ser-342, Ser-346, Ser-352 and Thr-353.	-
353	T	ubiquitylation	Phosphorylation at Ser-342, Ser-346, Ser-352 and Thr-353 prevents ubiquitination by the SCF(FBXL17) complex.	-
353	T	ubiquitylation	Ubiquitination is impaired by phosphorylation at Ser-342, Ser-346, Ser-352 and Thr-353.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SUFU_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SAP18_MOUSE	Sap18	physical	14611647
PIAS1_MOUSE	Pias1	physical	14611647
RN19A_MOUSE	Rnf19a	physical	14611647
SUH_MOUSE	Rbpj	physical	14611647
PRDX5_MOUSE	Prdx5	physical	14611647
GLI1_HUMAN	GLI1	physical	14611647
GLI3_HUMAN	GLI3	physical	14611647
CI_DROME	ci	physical	14611647
SAP18_DROME	Bin1	physical	14611647
SAP18_HUMAN	SAP18	physical	14611647
SAP18_HUMAN	SAP18	physical	11960000
SAP18_HUMAN	SAP18	genetic	11960000
SIN3A_MOUSE	Sin3a	physical	11960000
GLI1_MOUSE	Gli1	physical	16316410
GLI1_MOUSE	Gli1	physical	10531011
GLI2_MOUSE	Gli2	physical	10531011
GLI3_MOUSE	Gli3	physical	10531011
CI_DROME	ci	physical	11252182
FDL_DROME	fdl	physical	11252182

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.