CI_DROME - dbPTM
CI_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CI_DROME
UniProt AC P19538
Protein Name Transcriptional activator cubitus interruptus
Gene Name ci
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1397
Subcellular Localization Nucleus.
Protein Description Has a dual function as a transcriptional activator and a repressor of the hedgehog (Hh) pathway. The full-length ci form (ciFL), acts as an activator (ciA) while ciR, its C-terminally truncated form, acts as a repressor. Involved in segment polarity. Required for the normal development of the posterior half of each embryonic segment. Engrailed protein directly represses ci expression in posterior compartment cells. Essential component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required to activate Cad99C-dependent endosome formation, norpA-dependent Ca2+ mobilization and p38 MAPK, which are essential steps in the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection. [PubMed: 25639794]
Protein Sequence MDAYALPTYFPLAYSELQFLASRRAAAVAAAATVLPGSPCINQHHPTDVSSSVTVPSIIPTGGTSDSIKTSIQPQICNENTLLGNAGHQHNHQPQHVHNINVTGQPHDFHPAYRIPGYMEQLYSLQRTNSASSFHDPYVNCASAFHLAGLGLGSADFLGSRGLSSLGELHNAAVAAAAAGSLASTDFHFSVDGNRRLGSPRPPGGSIRASISRKRALSSSPYSDSFDINSMIRFSPNSLATIMNGSRGSSAASGSYGHISATALNPMSHVHSTRLQQIQAHLLRASAGLLNPMTPQQVAASGFSIGHMPTSASLRVNDVHPNLSDSHIQITTSPTVTKDVSQVPAAAFSLKNLDDAREKKGPFKDVVPEQPSSTSGGVAQVEADSASSQLSDRCYNNVVNNITGIPGDVKVNSRLDEYINCGSISIPSNEYDCANADTTDIKDEPGDFIETNCHWRSCRIEFITQDELVKHINNDHIQTNKKAFVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFYANKKHKGLPLNDANSRLQQNNSRHNLQEHNIDSSPCSEDSHLGKMLGTSSPSIKSESDISSSNHHLVNGVRASDSLLTYSPDDLAENLNLDDGWNCDDDVDVADLPIVLRAMVNIGNGNASASTIGGSVLARQRFRGRLQTKGINSSTIMLCNIPESNRTFGISELNQRITELKMEPGTDAEIKIPKLPNTTIGGYTEDPLQNQTSFRNTVSNKQGTVSGSIQGQFRRDSQNSTASTYYGSMQSRRSSQSSQVSSIPTMRPNPSCNSTASFYDPISPGCSRRSSQMSNGANCNSFTSTSGLPVLNKESNKSLNACINKPNIGVQGVGIYNSSLPPPPSSHLIATNLKRLQRKDSEYHNFTSGRFSVPSYMHSLHIKNNKPVGENEFDKAIASNARRQTDPVPNINLDPLTNISRFSTTPHSFDINVGKTNNIASSINKDNLRKDLFTVSIKADMAMTSDQHPNERINLDEVEELILPDEMLQYLNLVKDDTNHLEKEHQAVPVGSNVSETIASNHYREQSNIYYTNKQILTPPSNVDIQPNTTKFTVQDKFAMTAVGGSFSQRELSTLAVPNEHGHAKCESFHHQSQKYMNTDIGSKQQSALPSAHQRQTEKSNYNQIIDSSMTSLPELNVDSIYPRNETENIFKVHGDHDNEIQCGIISQSQMSPSTNLNNDGQFSTVNMQPITTSKLFPPEPQKIVCDTQASNTSVMHLDTYQRTLEYVQSCQNWMETNNTSTNQIQSLPGMPVNNTLFPDVSSSTHPYHGTNMVINDMTTSLTSLLEENRYLQMMQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
113PhosphorylationPHDFHPAYRIPGYME
CCCCCCHHHCCCHHH		17.3322817900
199PhosphorylationDGNRRLGSPRPPGGS
CCCCCCCCCCCCCCC		23.4822817900
852PhosphorylationTYYGSMQSRRSSQSS
HHHHHHHCCCCCCCC		22.4811912487
856PhosphorylationSMQSRRSSQSSQVSS
HHHCCCCCCCCCCCC		32.0710557210
884PhosphorylationASFYDPISPGCSRRS
CCCCCCCCCCCCCCH		22.1911912487
888PhosphorylationDPISPGCSRRSSQMS
CCCCCCCCCCHHCCC		36.3211912487
892PhosphorylationPGCSRRSSQMSNGAN
CCCCCCHHCCCCCCC		28.2610557210
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
852SPhosphorylationKinaseSGGP18431
PhosphoELM
856SPhosphorylationKinasePKA-FAMILY-GPS
856SPhosphorylationKinasePKA_GROUP-PhosphoELM
884SPhosphorylationKinaseSGGP18431
PhosphoELM
888SPhosphorylationKinaseSGGP18431
PhosphoELM
892SPhosphorylationKinasePKA-FAMILY-GPS
892SPhosphorylationKinasePKA_GROUP-PhosphoELM
-KUbiquitinationE3 ubiquitin ligaserdxQ9VFP2
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CI_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CI_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
COS_DROMEcosphysical
9244298
COS_DROMEcosphysical
10825151
FUSED_DROMEfuphysical
10825151
ACT3_DROMEAct57Bphysical
15710747
AJUBA_DROMEjubphysical
15710747
LYSB_DROMELysBphysical
15710747
NOC_DROMEnocphysical
15710747
NRT_DROMENrtphysical
15710747
ZFH2_DROMEzfh2physical
15710747
CSKP_DROMECASKphysical
15710747
PGM_DROMEPgmphysical
15710747
PERC_DROMEPxtphysical
15710747
RPB1_DROMERpII215physical
15710747
VATB_DROMEVha55physical
15710747
BN3D1_DROMEbin3physical
15710747
EXT3_DROMEbotvphysical
15710747
CEG1A_DROMECenG1Aphysical
15710747
NOL6_DROMEMat89Baphysical
15710747
CNO10_DROMENot10physical
15710747
SMG1_DROMEnonCphysical
15710747
MSTAA_DROMEmstaphysical
15710747
MSTAB_DROMEmstaphysical
15710747
U518_DROMECG3558physical
15710747
ANM7_DROMEArt7physical
15710747
CLH_DROMEChcphysical
15710747
CI_DROMEciphysical
15710747
CCNE_DROMECycEphysical
15710747
DCO_DROMEdcophysical
15710747
EIF3C_DROMEeIF3-S8physical
15710747
ELBOW_DROMEelBphysical
15710747
FTZF1_DROMEftz-f1physical
15710747
FUCTC_DROMEFucTCphysical
15710747
FRIZ3_DROMEfz3physical
15710747
GLNA2_DROMEGs2physical
15710747
HTH_DROMEhthphysical
15710747
JING_DROMEjingphysical
15710747
KNIR_DROMEkniphysical
15710747
LAMB1_DROMELanB1physical
15710747
KDM5_DROMElidphysical
15710747
ATR_DROMEmei-41physical
15710747
MYOD_DROMEnauphysical
15710747
NOI_DROMEnoiphysical
15710747
PIP1_DROMEPlc21Cphysical
15710747
PP2B2_DROMEPp2B-14Dphysical
15710747
PRD_DROMEprdphysical
15710747
EXOC3_DROMESec6physical
15710747
MED13_DROMEskdphysical
15710747
SLIT_DROMEsliphysical
15710747
M3KSL_DROMEslprphysical
15710747
SNAP_DROMEalphaSnapphysical
15710747
SUZ2_DROMESu(z)2physical
15710747
TIG_DROMETigphysical
15710747
RDX_DROMErdxphysical
16740475
RS27A_DROMERpS27Aphysical
23747190
NPL4_DROMENpl4physical
23747190
UBP7_DROMEUsp7physical
26120032
ARM_DROMEarmgenetic
11784100
PHP_DROMEph-pgenetic
10906453
WNTG_DROMEwggenetic
11784100
TSH_DROMEtshgenetic
11784100
HMEN_DROMEengenetic
9023986
PSC_DROMEPscgenetic
10906453
EGFR_DROMEEgfrgenetic
1980740
HMPB_DROMEpbgenetic
15680366
RDX_DROMErdxgenetic
16740475
HH_DROMEhhgenetic
10704398
COLL_DROMEkngenetic
10375526
SGG_DROMEsggphysical
21852395
KC1A_DROMECkIalphaphysical
21852395
FUSED_DROMEfuphysical
14597576
FUSED_DROMEfuphysical
15063184
SMO_DROMEsmophysical
17284519
COS_DROMEcosphysical
15063184
COS_DROMEcosphysical
20850429
COS_DROMEcosphysical
21852395
COS_DROMEcosphysical
26120032
COS_DROMEcosphysical
26271100
CUL1_DROMECul1physical
17925225
PTC_DROMEptcphysical
17284519
HIPPO_DROMEhpophysical
26403189
SXL_DROMESxlphysical
14597576
SXL_DROMESxlphysical
17284519
YAP1_DROMEykiphysical
26403189
HDAC1_DROMERpd3physical
24385484
RDX_DROMErdxphysical
21179535
RDX_DROMErdxphysical
24603360
RDX_DROMErdxphysical
25512501
MED13_DROMEskdphysical
24962581
MED12_DROMEktophysical
24962581
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CI_DROME

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Related Literatures of Post-Translational Modification

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