| UniProt ID | FTZF1_DROME | |
|---|---|---|
| UniProt AC | P33244 | |
| Protein Name | Nuclear hormone receptor FTZ-F1 | |
| Gene Name | ftz-f1 | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 1027 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Acts as a cofactor to fushi tarazu (ftz). Facilitates the binding of ftz to DNA. Binds the sequence element 5'-YCYYGGYCR-3' in the zebra element of ftz. Probably also functions as a receptor for a yet unknown ligand.. | |
| Protein Sequence | MDTFNVPMLAESSNTNYATEATSNHHHLQHQHQQQHSHQQQQQQQLLMPHHHKDQMLAAGSSPMLPFYSHLQLQQKDATATIGPAAAAAAVEAATTSANADNFSSLQTIDASQLDGGISLSGLCDRFFVASPNPHSNSNMTLMGTATAATTTTTNNNNNNNTNNNNNNNVEAKTVRPSNGNSVIIESVTMPSFANILFPTHRSANECIDPALLQKNPQNPNGNNSSIIVPPVEYHQLKPLEVNSSTSVSTSNFLSSTTAQLLDFEVQVGKDDGHISTTTTTGPGSGSASGSGSGSGSGSGSIARTIGTATPTTTTSMSNTANPTRSSLHSIEELAASSCAPRAASPNSNHTSSASTTPQQQQQQQHHMQSGNHSGSNLSSDDESMSEDEFGLEIDDNGGYQDTTSSHSQQSGGGGGGGGGNLLNGSSGGSSAGGGYMLLPQAASSSGNNGNPNAGHMSSGSVGNGSGGAGNGGAGGNSGPGNPMGGTSATPGHGGEVIDFKHLFEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAERSCHIDKTQRKRCPYCRFQKCLEVGMKLEAVRADRMRGGRNKFGPMYKRDRARKLQVMRQRQLALQALRNSMGPDIKPTPISPGYQQAYPNMNIKQEIQIPQVSSLTQSPDSSPSPIAIALGQVNASTGGVIATPMNAGTGGSGGGGLNGPSSVGNGNSSNGSSNGNNNSSTGNGTSGGGGGNNAGGGGGGTNSNDGLHRNGGNGNSSCHEAGIGSLQNTADSKLCFDSGTHPSSTADALIEPLRVSPMIREFVQSIDDREWQTQLFALLQKQTYNQVEVDLFELMCKVLDQNLFSQVDWARNTVFFKDLKVDDQMKLLQHSWSDMLVLDHLHHRIHNGLPDETQLNNGQVFNLMSLGLLGVPQLGDYFNELQNKLQDLKFDMGDYVCMKFLILLNPSVRGIVNRKTVSEGHDNVQAALLDYTLTCYPSVNDKFRGLVNILPEIHAMAVRGEDHLYTKHCAGSAPTQTLLMEMLHAKRKG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 326 | Phosphorylation | NTANPTRSSLHSIEE CCCCCCHHHHHHHHH | 39.47 | 21082442 | |
| 327 | Phosphorylation | TANPTRSSLHSIEEL CCCCCHHHHHHHHHH | 27.15 | 22817900 | |
| 330 | Phosphorylation | PTRSSLHSIEELAAS CCHHHHHHHHHHHHC | 36.67 | 21082442 | |
| 418 (in isoform 2) | Sumoylation | - | 44.07 | - | |
| 629 | Phosphorylation | DIKPTPISPGYQQAY CCCCCCCCCCCHHCC | 17.30 | 21082442 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FTZF1_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FTZF1_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FTZF1_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RLA2_DROME | RpLP2 | physical | 14605208 | |
| CIC_DROME | cic | physical | 14605208 | |
| DICH_DROME | D | physical | 14605208 | |
| RS8_DROME | RpS8 | physical | 14605208 | |
| EF1A1_DROME | Ef1alpha48D | physical | 14605208 | |
| RS29_DROME | RpS29 | physical | 14605208 | |
| ECR_DROME | EcR | genetic | 21131955 | |
| FTZ_DROME | ftz | genetic | 11592991 | |
| FTZ_DROME | ftz | genetic | 14654217 | |
| BRC1_DROME | br | genetic | 11060234 | |
| BRC4_DROME | br | genetic | 11060234 | |
| RIG_DROME | rig | physical | 14645129 | |
| FTZ_DROME | ftz | physical | 11157757 | |
| TBB2_DROME | betaTub85D | physical | 25242320 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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