FTZ_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FTZ_DROME
• UniProt AC: P02835
• Protein Name: Segmentation protein fushi tarazu
• Gene Name: ftz
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 410
• Subcellular Localization: Nucleus .
• Protein Description: May play a role in determining neuronal identity, may be directly involved in specifying identity of individual neurons. Required during embryogenesis for the process of body segmentation. Homeotic protein, required in alternating segment primordia, it specifies the correct number of segments..
• Protein Sequence: MATTNSQSHYSYADNMNMYNMYHPHSLPPTYYDNSGSNAYYQNTSNYQGYYPQESYSESCYYYNNQEQVTTQTVPPVQPTTPPPKATKRKAEDDAASIIAAVEERPSTLRALLTNPVKKLKYTPDYFYTTVEQVKKAPAVSTKVTASPAPSYDQEYVTVPTPSASEDVDYLDVYSPQSQTQKLKNGDFATPPPTTPTSLPPLEGISTPPQSPGEKSSSAVSQEINHRIVTAPNGAGDFNWSHIEETLASDCKDSKRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSKKDRTLDSSPEHCGAGYTAMLPPLEATSTATTGAPSVPVPMYHHHQTTAAYPAYSHSHSHGYGLLNDYPQQQTHQQYDAYPQQYQHQCSYQQHPQDLYHLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
262	Phosphorylation	KRTRQTYTRYQTLEL HHHHHHHHHHHHHHH	26.70	9545243

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
262	T	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
262	T	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FTZ_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FTZ_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
Y3427_DROME	CG43427	physical	14605208
K10_DROME	fs(1)K10	physical	14605208
FTZF1_DROME	ftz-f1	physical	14605208
EVE_DROME	eve	genetic	11245576
FTZF1_DROME	ftz-f1	genetic	15454535
HUNB_DROME	hb	genetic	3100363
HTH_DROME	hth	genetic	15454535
HOW_DROME	how	genetic	15454535
IF4E_DROME	eIF-4E	genetic	15454535
PRD_DROME	prd	physical	9020363
PRD_DROME	prd	physical	11157757
FTZF1_DROME	ftz-f1	physical	9020363
FTZF1_DROME	ftz-f1	physical	9020364
FTZF1_DROME	ftz-f1	physical	11520662
FTZF1_DROME	ftz-f1	physical	11157757
FTZF1_DROME	ftz-f1	physical	10381570
FTZF1_DROME	ftz-f1	physical	11592991

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.