dbPTM

RIG_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RIG_DROME
UniProt AC	Q86BY9
Protein Name	Protein rigor mortis
Gene Name	rig
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1235
Subcellular Localization	Nucleus. Cytoplasm. During second and third instar larval development, it is localized primarily to the cytoplasm of cells in the brain and imaginal disks (tissues that are fated to form specific parts of the adult fly during metamorphosis). Also loc
Protein Description	Nuclear receptor cofactor for the ecdysone-regulated processes of molting and puparium formation. Acts downstream from ecdysone biosynthesis and release to control the expression of specific ecdysone-regulated genes such as Eip74EF (E74)..
Protein Sequence	MNSQVMYHNVPTPPGNVSLAAAAPDGGLLYAGIRCINYISAPPANGEQPQVVTMSTRINILALDVSPMWGLGNGGPTKPFAIVGDDLSVQVWDCALGEAVIGHKAHQHQHEARDVRVVHHTTNSVLMSYLANGNILSMDASDLVIYCVASNTYCRRSTFISPRNHQLTMVRCSPYNDNLFAVGTAMGNVLVCDLRKMNIVYKFHGHKAPICGLAWREVPAAEDEKTNNLALSAEEWRSRNGGQEEKPKTKPPPLTKSKAAESDDPFDIYNFDHLEYEFGAPIAERRRKSSEDCGGEFVGLEKPAGAAVLDFVEACESVKAELLASRQEDKTQHVEVTLHDCEPTKPTGPLSDASTISNKNDASDSTEGSLEVIQYSSSSDDAVIVDGEAAKPKREVLHHIYHQAEVHASGTPQTKSEPQSNLQVVPAISAETISLTSVNSTHLETLLVSIDGDEVMMIWNTNTGAHAGKNYSKSKTAGKLNNVYWLNNHVIVSLSRHQLFFWSVEFERKMLRYKISKDKSHSCHLQDIVSFACDSSKEMIWLCRNNRQIGMMNPKTGRMADFYGTVAFGVRAMAECPDDMNKIALGCSDRRVAFFDISKLTTSCLPIDSVYVSSNVYCLAWSPNCLELAFGTFDGTVGILDVERMKVKTHLRTPHKKEVYSLVWQDHFIYFIVNRVLGFFDLRKSKIEPTIVNCISRPSYLSIRDSFLFVGTDDGLLQIHERDSGMEKSWSPFIRQSALFARYVTDIAWCPLDSNKFAVSGNDRSVYVMEFQPTERNWKTLHTFTANTEKASITSMRWSHTQKHLLLTFHIEGKVCLWNCNAPEKPPLTITYHCPMWCGMFLPTNENIIMCSGKALSVELIDIKDALEGDEKSICPKVDALLNVKWASKSLTQPYAPVLTAAEKKRQRRDQRKAAAKLEVDVANKDQKKIQESVTAVIDNPTNDKCTQETPVEEMLEALSLDKEQNNRSAKECPKCKEQSPDSFTHSRTCLYLTQKELNKSALEKLAIVLTEDSAKIDKSVLISKLFSSKVMAKELIATELTNLKHSNTKDIAPLCLAMSTFKLREELEQHIANKTLTERHVSLAPSVSFTLWQDCCRAYAKQMEEKGYIMHAATYLFSQGMQSEAIKLFLANEYYKEALVHARICLPATDPLIKTVINNWLEHLEGTGNFAAAALICVLDNEMLRGYSYLRKYRNCTPEIADLMDQIKRIGQLGGVLDGCAPNEPIHNGSTAEH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
289	Phosphorylation	IAERRRKSSEDCGGE HHHHHHHCCCCCCCC	36.83	19429919
290	Phosphorylation	AERRRKSSEDCGGEF HHHHHHCCCCCCCCC	40.25	19429919
351	Phosphorylation	TKPTGPLSDASTISN CCCCCCCCCCCCCCC	33.97	18327897
354	Phosphorylation	TGPLSDASTISNKND CCCCCCCCCCCCCCC	31.12	18327897
355	Phosphorylation	GPLSDASTISNKNDA CCCCCCCCCCCCCCC	30.10	18327897
357	Phosphorylation	LSDASTISNKNDASD CCCCCCCCCCCCCCC	41.67	18327897
411	Phosphorylation	AEVHASGTPQTKSEP CCHHCCCCCCCCCCC	15.10	18327897
636	Phosphorylation	AFGTFDGTVGILDVE HEEECCCCEEEEEHH	19.87	22817900
980	Phosphorylation	CPKCKEQSPDSFTHS CCCCCCCCCCCCCHH	31.59	19429919
983	Phosphorylation	CKEQSPDSFTHSRTC CCCCCCCCCCHHHHH	35.11	19429919
985	Phosphorylation	EQSPDSFTHSRTCLY CCCCCCCCHHHHHHH	23.93	19429919
987	Phosphorylation	SPDSFTHSRTCLYLT CCCCCCHHHHHHHHC	26.65	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RIG_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RIG_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RIG_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HR3_DROME	Hr46	physical	14645129
FTF1B_DROME	Hr39	physical	14645129
GRK_DROME	grk	physical	23213441

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RIG_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289; SER-290; SER-351;SER-354; THR-355; SER-357 AND THR-411, AND MASS SPECTROMETRY.	18327897 [Abstract]