FTF1B_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FTF1B_DROME
• UniProt AC: Q05192
• Protein Name: Nuclear hormone receptor FTZ-F1 beta
• Gene Name: Hr39
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 808
• Subcellular Localization: Nucleus.
• Protein Description: Acts as a cofactor to fushi tarazu (ftz). Facilitates the binding of ftz to DNA. Binds the sequence element 5'-YCYYGGYCR-3' in the zebra element of ftz. Probably also functions as a receptor for a yet unknown ligand..
• Protein Sequence: MPNMSSIKAEQQSGPLGGSSGYQVPVNMCTTTVANTTTTLGSSAGGATGSRHNVSVTNIKCELDELPSPNGNMVPVIANYVHGSLRIPLSGHSNHRESDSEEELASIENLKVRRRTAADKNGPRPMSWEGELSDTEVNGGEELMEMEPTIKSEVVPAVAPPQPVCALQPIKTELENIAGEMQIQEKCYPQSNTQHHAATKLKVAPTQSDPINLKFEPPLGDNSPLLAARSKSSSGGHLPLPTNPSPDSAIHSVYTHSSPSQSPLTSRHAPYTPSLSRNNSDASHSSCYSYSSEFSPTHSPIQARHAPPAGTLYGNHHGIYRQMKVEASSTVPSSGQEAQNLSMDSASSNLDTVGLGSSHPASPAGISRQQLINSPCPICGDKISGFHYGIFSCESCKGFFKRTVQNRKNYVCVRGGPCQVSISTRKKCPACRFEKCLQKGMKLEAIREDRTRGGRSTYQCSYTLPNSMLSPLLSPDQAAAAAAAAAVASQQQPHQRLHQLNGFGGVPIPCSTSLPASPSLAGTSVKSEEMAETGKQSLRTGSVPPLLQEIMDVEHLWQYTDAELARINQPLSAFASGSSSSSSSSGTSSGAHAQLTNPLLASAGLSSNGENANPDLIAHLCNVADHRLYKIVKWCKSLPLFKNISIDDQICLLINSWCELLLFSCCFRSIDTPGEIKMSQGRKITLSQAKSNGLQTCIERMLNLTDHLRRLRVDRYEYVAMKVIVLLQSDTTELQEAVKVRECQEKALQSLQAYTLAHYPDTPSKFGELLLRIPDLQRTCQLGKEMLTIKTRDGADFNLLMELLRGEH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	Phosphorylation	TGSRHNVSVTNIKCE CCCCCEEEEEEEEEE	28.65	21082442
90	Phosphorylation	GSLRIPLSGHSNHRE EEEECCCCCCCCCCC	29.16	19429919
93	Phosphorylation	RIPLSGHSNHRESDS ECCCCCCCCCCCCCC	37.55	19429919
98	Phosphorylation	GHSNHRESDSEEELA CCCCCCCCCCHHHHH	46.52	19429919
100	Phosphorylation	SNHRESDSEEELASI CCCCCCCCHHHHHHH	57.07	19429919
106	Phosphorylation	DSEEELASIENLKVR CCHHHHHHHHHHHHH	42.96	19429919
127	Phosphorylation	KNGPRPMSWEGELSD CCCCCCCCCCCCCCC	25.34	18327897
271	Phosphorylation	LTSRHAPYTPSLSRN CCCCCCCCCCCCCCC	31.87	19429919
272	Phosphorylation	TSRHAPYTPSLSRNN CCCCCCCCCCCCCCC	12.82	19429919
274	Phosphorylation	RHAPYTPSLSRNNSD CCCCCCCCCCCCCCC	31.04	19429919
276	Phosphorylation	APYTPSLSRNNSDAS CCCCCCCCCCCCCCC	36.98	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FTF1B_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FTF1B_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FTF1B_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ECR_DROME	EcR	genetic	21131955
FTZF1_DROME	ftz-f1	genetic	21131955

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90; SER-98; SER-100;SER-106; SER-127 AND SER-276, AND MASS SPECTROMETRY.
PubMed: 18327897