| UniProt ID | ECR_DROME | |
|---|---|---|
| UniProt AC | P34021 | |
| Protein Name | Ecdysone receptor | |
| Gene Name | EcR | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 878 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Receptor for ecdysone. Binds to ecdysone response elements (ECRES) following ecdysone-binding, and recruitment of a complex containing the histone methyltransferase trr, leads to activate transcription of target genes.. | |
| Protein Sequence | MKRRWSNNGGFMRLPEESSSEVTSSSNGLVLPSGVNMSPSSLDSHDYCDQDLWLCGNESGSFGGSNGHGLSQQQQSVITLAMHGCSSTLPAQTTIIPINGNANGNGGSTNGQYVPGATNLGALANGMLNGGFNGMQQQIQNGHGLINSTTPSTPTTPLHLQQNLGGAGGGGIGGMGILHHANGTPNGLIGVVGGGGGVGLGVGGGGVGGLGMQHTPRSDSVNSISSGRDDLSPSSSLNGYSANESCDAKKSKKGPAPRVQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEPPQHATIPLLPDEILAKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDENESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGMADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIFSDRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIWDVHAIPPSVQSHLQITQEENERLERAERMRASVGGAITAGIDCDSASTSAAAAAAQHQPQPQPQPQPSSLTQNDSQHQTQPQLQPQLPPQLQGQLQPQLQPQLQTQLQPQIQPQPQLLPVSAPVPASVTAPGSLSAVSTSSEYMGGSAAIGPITPATTSSITAAVTASSTTSAVPMGNGVGVGVGVGGNVSMYANAQTAMALMGVALHSHQEQLIGGVAVKSEHSTTA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MKRRWSNNGGFMR --CCCCCCCCCCCCC | 20.71 | 19429919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ECR_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ECR_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ECR_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RIG_DROME | rig | physical | 14645129 | |
| TRR_DROME | trr | physical | 14603321 | |
| CSN2_HUMAN | COPS2 | physical | 10207062 | |
| TRR_DROME | trr | genetic | 14603321 | |
| ABRU_DROME | ab | genetic | 19350016 | |
| ISWI_DROME | Iswi | genetic | 16264191 | |
| SOX14_DROME | Sox14 | genetic | 19881505 | |
| IPYR_DROME | Nurf-38 | genetic | 16264191 | |
| MICAL_DROME | Mical | genetic | 19881505 | |
| HDC_DROME | hdc | genetic | 23197702 | |
| NU301_DROME | E(bx) | genetic | 16264191 | |
| ITBX_DROME | mys | genetic | 12958367 | |
| USP_DROME | usp | physical | 26222308 | |
| USP_DROME | usp | physical | 17956872 | |
| USP_DROME | usp | physical | 18980211 | |
| USP_DROME | usp | physical | 8524239 | |
| MED15_DROME | MED15 | physical | 26222308 | |
| ECR_DROME | EcR | physical | 18771703 | |
| RIG_DROME | rig | physical | 26222308 | |
| MED14_DROME | MED14 | physical | 26222308 | |
| CDK8_DROME | Cdk8 | physical | 26222308 | |
| MED1_DROME | MED1 | physical | 26222308 | |
| CCNC_DROME | CycC | physical | 26222308 | |
| HSP7D_DROME | Hsc70-4 | physical | 26222308 | |
| FKB39_DROME | FK506-bp1 | physical | 17956872 | |
| MED26_DROME | MED26 | physical | 26222308 | |
| MED13_DROME | skd | physical | 26222308 | |
| MED12_DROME | kto | physical | 26222308 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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