| UniProt ID | IPYR_DROME | |
|---|---|---|
| UniProt AC | O77460 | |
| Protein Name | Inorganic pyrophosphatase | |
| Gene Name | Nurf-38 | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 338 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | Component of NURF (nucleosome remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. NURF is required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis. Nurf-38 may have adapted to deliver pyrophosphatase to chromatin to assist in replication or transcription by efficient removal of the inhibitory metabolite.. | |
| Protein Sequence | MLAKITRSSFYASRAVGRLSGSIPTSPAALASNCRYIQIERKRTKSHEMALYETVEKGAKNSPSYSLYFKNKCGNVISPMHDIPLYANEEKTIYNMVVEVPRWTNAKMEISLKTPMNPIKQDIKKGKLRFVANCFPHKGYIWNYGALPQTWENPDHIEPSTGCKGDNDPIDVIEIGYRVAKRGDVLKVKVLGTIALIDEGETDWKIIAIDVNDPLASKVNDIADVDQYFPGLLRATVEWFKIYKIPDGKPENQFAFNGDAKNADFANTIIAETHKFWQNLVHQSPASGSISTTNITNRNSEHVIPKEEAEKILAEAPDGGQVEEVSDTVDTWHFIHLK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 20 | Phosphorylation | SRAVGRLSGSIPTSP HHHHHHHCCCCCCCH | 29.18 | 22817900 | |
| 26 | Phosphorylation | LSGSIPTSPAALASN HCCCCCCCHHHHHHC | 13.74 | 22817900 | |
| 62 | Phosphorylation | VEKGAKNSPSYSLYF HHHHCCCCCCEEEEE | 17.95 | 22817900 | |
| 70 | Acetylation | PSYSLYFKNKCGNVI CCEEEEEECCCCCEE | 41.77 | 21791702 | |
| 306 | Acetylation | NSEHVIPKEEAEKIL CCCCCCCHHHHHHHH | 58.00 | 21791702 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IPYR_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IPYR_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IPYR_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PH4H_DROME | Hn | physical | 14605208 | |
| EF1A1_DROME | Ef1alpha48D | physical | 14605208 | |
| DOM_DROME | dom | physical | 14605208 | |
| CAF1_DROME | Caf1 | physical | 9784495 | |
| ISWI_DROME | Iswi | physical | 9784495 | |
| NU301_DROME | E(bx) | physical | 11583616 | |
| ECR_DROME | EcR | physical | 16264191 | |
| NU301_DROME | E(bx) | physical | 8521501 | |
| NU301_DROME | E(bx) | physical | 8521502 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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