| UniProt ID | ISWI_DROME | |
|---|---|---|
| UniProt AC | Q24368 | |
| Protein Name | Chromatin-remodeling complex ATPase chain Iswi | |
| Gene Name | Iswi | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 1027 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Energy-transducing component of the chromatin-remodeling complexes NURF (nucleosome-remodeling factor), ACF (ATP-utilizing chromatin assembly and remodeling factor), and CHRAC (chromatin accessibility complex). NURF catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. It is required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis.. | |
| Protein Sequence | MSKTDTAAVEATEENSNETTSDAATSSSGEKEAEFDNKIEADRSRRFDFLLKQTEIFTHFMTNSAKSPTKPKGRPKKIKDKDKEKDVADHRHRKTEQEEDEELLAEDSATKEIFRFDASPAYIKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTSYEMCIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFLLPDVFNSSEDFDEWFNTNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLLKDIDVVNGAGKVEKMRLQNILMQLRKCTNHPYLFDGAEPGPPYTTDTHLVYNSGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVERAEVKLRLDKMVIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETDITDEDIDVILERGEAKTAEQKAALDSLGESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQKLNALGNWIEPPKRERKANYAVDAYFREALRVSEPKAPKAPRPPKQPIVQDFQFFPPRLFELLDQEIYYFRKTVGYKVPKNTELGSDATKVQREEQRKIDEAEPLTEEEIQEKENLLSQGFTAWTKRDFNQFIKANEKYGRDDIDNIAKDVEGKTPEEVIEYNAVFWERCTELQDIERIMGQIERGEGKIQRRLSIKKALDQKMSRYRAPFHQLRLQYGNNKGKNYTEIEDRFLVCMLHKLGFDKENVYEELRAAIRASPQFRFDWFIKSRTALELQRRCNTLITLIERENIELEEKERAEKKKKAPKGSVSAGSGSASSNTPAPAPQPKASQKRKSEVVATSSNSKKKKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 19 | Phosphorylation | TEENSNETTSDAATS CCCCCCCCCCCCCCC | 35.53 | 22817900 | |
| 67 | Phosphorylation | FMTNSAKSPTKPKGR HHCCCCCCCCCCCCC | 37.20 | 18327897 | |
| 269 | Phosphorylation | KNEKSKLSEILREFK HCCHHHHHHHHHHHH | 26.74 | 29892262 | |
| 337 | Acetylation | TRLHAVLKPFLLRRL HHHHHHHHHHHHHHH | 27.42 | 21791702 | |
| 388 | Acetylation | DVVNGAGKVEKMRLQ CCCCCCCHHHHHHHH | 46.84 | 21791702 | |
| 753 | Acetylation | FRKTVGYKVPKNTEL HHHCCCCCCCCCCCC | 46.24 | 17760996 | |
| 1013 | Phosphorylation | KASQKRKSEVVATSS CCCHHCHHCCEECCC | 39.39 | 21082442 | |
| 1022 | Phosphorylation | VVATSSNSKKKKK-- CEECCCCCCCCCC-- | 48.04 | 21082442 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ISWI_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ISWI_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ISWI_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CAF1_DROME | Caf1 | physical | 9419341 | |
| NU301_DROME | E(bx) | physical | 11583616 | |
| MOF_DROME | mof | genetic | 11882543 | |
| RPB1_DROME | RpII215 | genetic | 15944353 | |
| MLE_DROME | mle | genetic | 11882543 | |
| WUN_DROME | wun | genetic | 20194965 | |
| HDAC1_DROME | Rpd3 | genetic | 18535655 | |
| UBCD1_DROME | eff | genetic | 20194965 | |
| NU301_DROME | E(bx) | genetic | 18535655 | |
| NU301_DROME | E(bx) | genetic | 20194965 | |
| TTKB_DROME | ttk | genetic | 20194965 | |
| TTKA_DROME | ttk | genetic | 20194965 | |
| RX21_DROME | Rsf1 | physical | 26549447 | |
| IPYR_DROME | Nurf-38 | physical | 26549447 | |
| IPYR_DROME | Nurf-38 | physical | 9784495 | |
| IPYR_DROME | Nurf-38 | physical | 8521501 | |
| IPYR_DROME | Nurf-38 | physical | 8521502 | |
| HDAC1_DROME | Rpd3 | physical | 18535655 | |
| 18C_DROME | Mst77F | physical | 26549447 | |
| CTBP_DROME | CtBP | physical | 22426536 | |
| CAF1_DROME | Caf1 | physical | 26549447 | |
| CAF1_DROME | Caf1 | physical | 9784495 | |
| NU301_DROME | E(bx) | physical | 26549447 | |
| NU301_DROME | E(bx) | physical | 8521501 | |
| NU301_DROME | E(bx) | physical | 8521502 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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