MOF_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MOF_DROME
• UniProt AC: O02193
• Protein Name: Males-absent on the first protein
• Gene Name: mof
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 827
• Subcellular Localization: Chromosome . Nucleus .
• Protein Description: Histone acetyltransferase that plays a direct role in the specific histone acetylation associated with dosage compensation as part of the MSL complex. Dosage compensation insures that males with a single X chromosome have the same amount of most X-linked gene products as females with two X chromosomes. May be directly involved in the acetylation of histone 4 at 'Lys-16' on the X chromosome of males where it is recruited by the MSL complex. As part of the NSL complex may associate with promoters of X chromosomal as well as autosomal genes and positively regulate their transcription through chromatin modification..
• Protein Sequence: MSEAELEQTPSAGHVQEQPIEEEHEPEQEPTDAYTIGGPPRTPVEDAAAELSASLDVSGSDQSAEQSLDLSGVQAEAAAESEPPAKRQHRDISPISEDSTPASSTSTSSTRSSSSSRYDDVSEAEEAPPEPEPEQPQQQQQEEKKEDGQDQVKSPGPVELEAQEPAQPQKQKEVVDQEIETEDEPSSDTVICVADINPYGSGSNIDDFVMDPDAPPNAIITEVVTIPAPLHLKGTQQLGLPLAAPPPPPPPPAAEQVPETPASPTDDGEEPPAVYLSPYIRSRYMQESTPGLPTRLAPRDPRQRNMPPPAVVLPIQTVLSANVEAISDDSSETSSSDDDEEEEEDEDDALTMEHDNTSRETVITTGDPLMQKIDISENPDKIYFIRREDGTVHRGQVLQSRTTENAAAPDEYYVHYVGLNRRLDGWVGRHRISDNADDLGGITVLPAPPLAPDQPSTSREMLAQQAAAAAAASSERQKRAANKDYYLSYCENSRYDYSDRKMTRYQKRRYDEINHVQKSHAELTATQAALEKEHESITKIKYIDKLQFGNYEIDTWYFSPFPEEYGKARTLYVCEYCLKYMRFRSSYAYHLHECDRRRPPGREIYRKGNISIYEVNGKEESLYCQLLCLMAKLFLDHKVLYFDMDPFLFYILCETDKEGSHIVGYFSKEKKSLENYNVACILVLPPHQRKGFGKLLIAFSYELSRKEGVIGSPEKPLSDLGRLSYRSYWAYTLLELMKTRCAPEQITIKELSEMSGITHDDIIYTLQSMKMIKYWKGQNVICVTSKTIQDHLQLPQFKQPKLTIDTDYLVWSPQTAAAVVRAPGNSG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
93	Phosphorylation	KRQHRDISPISEDST CCCCCCCCCCCCCCC	22.07	19429919
96	Phosphorylation	HRDISPISEDSTPAS CCCCCCCCCCCCCCC	38.44	19429919
118	Phosphorylation	RSSSSSRYDDVSEAE CCCCCCCCCCHHHHH	20.60	19429919
122	Phosphorylation	SSRYDDVSEAEEAPP CCCCCCHHHHHCCCC	37.78	19429919
154	Phosphorylation	DGQDQVKSPGPVELE CCCCCCCCCCCCEEE	35.91	19429919
433	Phosphorylation	WVGRHRISDNADDLG CCCCCCCCCCCCCCC	25.43	19429919
443	Phosphorylation	ADDLGGITVLPAPPL CCCCCCEEEEECCCC	21.18	19429919
483	Acetylation	RQKRAANKDYYLSYC HHHHHCCCHHHHHHH	42.24	21791702
638	Acetylation	AKLFLDHKVLYFDMD HHHHCCCCEEEEECC	33.33	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MOF_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MOF_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MOF_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MSL1_DROME	msl-1	physical	10619853
H4_XENLA	hist1h4a	physical	15988010
MOF_DROME	mof	physical	16543150
NU153_DROME	Nup153	physical	16543150
CHD1_DROME	Chd1	physical	16543150
MSL2_DROME	msl-2	physical	16543150
MSL2_DROME	msl-2	physical	11014199
MSL2_DROME	msl-2	physical	25694028
MSL1_DROME	msl-1	physical	16543150
MSL1_DROME	msl-1	physical	15141166
MSL1_DROME	msl-1	physical	25694028
MLE_DROME	mle	physical	11014199
MLE_DROME	mle	physical	25694028
TPR_DROME	Mtor	physical	16543150
MSL3_DROME	msl-3	physical	16543150
MSL3_DROME	msl-3	physical	25242320
MSL3_DROME	msl-3	physical	11014199
MSL3_DROME	msl-3	physical	15141166
MSL3_DROME	msl-3	physical	25694028
TBA1_DROME	alphaTub84B	physical	16543150
WDS_DROME	wds	physical	16543150

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.