MSL1_DROME - dbPTM
MSL1_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MSL1_DROME
UniProt AC P50535
Protein Name Protein male-specific lethal-1
Gene Name msl-1
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1039
Subcellular Localization Nucleus. Chromosome. Msl-1 is associated with hundreds of discrete sites along the length of the X chromosome in males and not in females, and is also associated with 10-20 autosomal sites in males.
Protein Description The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-1 is a pioneer protein. Mle, msl-1 and msl-3 are colocalized on the X chromosome. Each of the MSL proteins requires all the other MSLs for wild-type X-chromosome binding. In complex with msl-2, promotes ubiquitination of histone H2B..
Protein Sequence MDKRFKWPPKKRANYLESPYPHIPSRGRQRNLHGHPNQTQHLHQHPGKIYERQQYGNGRGGHGGGNNNYRKLLHSLPAEHGGGAMAPPSSGGTVCAGADMVKLISENNNLRRMVMLNLNLMQEQTDSIAAKDKELDDQSAKMSVVKAQNEELKQAVAQLEAANQELCKQLRRKNQRRNDNDDDDDDPPLPPAAPQQKLIRCHAETQTVFREREQGTQTIDAQPQFANALPRGINMKESPALDHHAGAVTNQPASKRSESKGRGEFNGKKVSTFILQRMNQDFEHHIHEQTEVAEEHEMEAHKEQISQEEDQLVAEEDHLHMQEVHTEEVVGGDIFHDALESIEMEVVTEELVDMEEHGQSVDANGHIEEDDDEDDEDDENSDKDDDSEEDDYPWMHSDADVNARTEEELWQNQNYLLELDPTEEKTCAPSAHSTPNHQQKSSTQAEIRKEGNQNRITEKLLQLKPEPMVDALEAPILPKWVAFKKKDKEHESVPESPEVPKQQPHQEDAIVDHNAIKNQLEVPKPDLKPKDQPKDEQRQDGQLDVRVEPQEDVRKVQKETLKRQPEDAPKHLPKAVAPKVTKTSSRESTLPKANTADIKDAPAQKVIANHQSTKTQTDPVKTQRLQVKIRQYEMHPDMRTGSSAPSDIRKQKNVDPVSTPETKTIKSKSMLVNDKKTTSETSQSPDQEIDVETVRRKLAEHLKKELLSQSHSSQVTLKKIRERVATNLIYPPPSAPVSSTTITPAPTPSTTPTPGSTPQHAVTSSMDQEISAAKSKSKAAEQIATPLTPQSNSSVSSTTSTIRKTLNNCSPHTYSKATARSGKLQSRFRTATFPYSTRTWEDQEFHCDNEFFLEEADELLADNPSLEIPKWRDVPVPPSSDKIDTELLSDATFERRHQKYVKDEVDRKCRDARYMKEQIRLEQLRMRRNQDEVLVALDPLRASTFYPLPEDIEAIQFVNEVTVQAFGENVVNMEARDDFGVPWVDAIEAPTSIARSKALAEPVATLASKKIPTTAAEARHQENHSSYVFPKRRKRQKNR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
125PhosphorylationLNLMQEQTDSIAAKD
HHHHHHHHHHHHHHC		30.8422668510
139PhosphorylationDKELDDQSAKMSVVK
CHHCCCHHHHHHHHH		36.5322668510
387PhosphorylationNSDKDDDSEEDDYPW
CCCCCCCCCCCCCCC		50.2919429919
496PhosphorylationEHESVPESPEVPKQQ
CCCCCCCCCCCCCCC		21.9319429919
658PhosphorylationQKNVDPVSTPETKTI
CCCCCCCCCCCCCCC		43.5719429919
659PhosphorylationKNVDPVSTPETKTIK
CCCCCCCCCCCCCCC		25.9419429919
677PhosphorylationMLVNDKKTTSETSQS
CEECCCCCCCCCCCC		41.0919429919
678PhosphorylationLVNDKKTTSETSQSP
EECCCCCCCCCCCCC		33.1819429919
679PhosphorylationVNDKKTTSETSQSPD
ECCCCCCCCCCCCCC		44.0729892262
681PhosphorylationDKKTTSETSQSPDQE
CCCCCCCCCCCCCCC		31.6519429919
682PhosphorylationKKTTSETSQSPDQEI
CCCCCCCCCCCCCCC		25.3019429919
684PhosphorylationTTSETSQSPDQEIDV
CCCCCCCCCCCCCCH		30.1619429919
810PhosphorylationRKTLNNCSPHTYSKA
HHHHHCCCCCCCCHH		23.1127626673
816AcetylationCSPHTYSKATARSGK
CCCCCCCHHHHCCCC		39.0721791702
916AcetylationCRDARYMKEQIRLEQ
HHHHHHHHHHHHHHH		37.2221791702
997AcetylationPTSIARSKALAEPVA
CCHHHHHHHHHHHHH		41.7021791702
1009AcetylationPVATLASKKIPTTAA
HHHHHHHCCCCCCHH		49.4621791702
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MSL1_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MSL1_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MSL1_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NAT9_DROMECG11539physical
14605208
JIL1_DROMEJIL-1physical
10831604
MSL2_DROMEmsl-2physical
10619853
MSL3_DROMEmsl-3physical
10619853
MOF_DROMEmofphysical
10619853
H2B2E_HUMANHIST2H2BEphysical
21726816
MOF_DROMEmofphysical
21217699
MSL1_DROMEmsl-1physical
23084835
MSL3_DROMEmsl-3physical
23084835
MOF_DROMEmofphysical
23084835
MSL2_DROMEmsl-2physical
23084835
MSL1_DROMEmsl-1physical
23870142
MSL2_DROMEmsl-2physical
23870142
MSL3_DROMEmsl-3physical
23870142
MOF_DROMEmofphysical
23870142
MLE_DROMEmlephysical
23870142
MSL2_DROMEmsl-2genetic
10619853
MOF_DROMEmofphysical
10594033
MOF_DROMEmofphysical
15141166
MOF_DROMEmofphysical
16543150
MOF_DROMEmofphysical
20620954
MOF_DROMEmofphysical
27183194
MSL2_DROMEmsl-2physical
10594033
MSL2_DROMEmsl-2physical
21217699
MSL2_DROMEmsl-2physical
7781064
MSL2_DROMEmsl-2physical
9736618
MSL2_DROMEmsl-2physical
20139418
MSL2_DROMEmsl-2physical
25694028
MLE_DROMEmlephysical
10594033
MLE_DROMEmlephysical
21217699
MSL3_DROMEmsl-3physical
10594033
MSL3_DROMEmsl-3physical
15141166
MSL3_DROMEmsl-3physical
16543150
MSL3_DROMEmsl-3physical
20620954
MSL3_DROMEmsl-3physical
21217699
MSL3_DROMEmsl-3physical
27183194
MSL3_DROMEmsl-3physical
9736618
MSL3_DROMEmsl-3physical
25694028
JIL1_DROMEJIL-1physical
25694028
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MSL1_DROME

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Related Literatures of Post-Translational Modification

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