dbPTM

MSL3_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MSL3_DROME
UniProt AC	P50536
Protein Name	Protein male-specific lethal-3
Gene Name	msl-3
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	512
Subcellular Localization	Nucleus . Chromosome . Msl-3 is associated with hundreds of discrete sites along the length of the X chromosome in males and not in females, and is also associated with 10-20 autosomal sites in males.
Protein Description	The MSL proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Mle, msl-1 and msl-3 are colocalized on the X chromosome. Each of the MSL proteins requires all the other MSLs for wild-type X-chromosome binding..
Protein Sequence	MTELRDETPLFHKGEIVLCYEPDKSKARVLYTSKVLNVFERRNEHGLRFYEYKIHFQGWRPSYDRCVRATVLLKDTEENRQLQRELAEAAKLQIRGDYSYKGTPDKPSAKKKRGGKAAHVEEPIVVPMDTGHLEAEHEMAPTPRAAGNRTRDNSGGKRKEKPPSGDGRLKGNRGRQTETFYNNAINDVSVYNHVPQEDRIMMRVSERLRELIEYDRNMIKVLGKQHALPARVPIVTIMENFVKQQAVELAISIKQDSSRARNTQSRNARMEREYDRVMSTVCMLKEVVDGLRIYFEFHVDDHLLYTEEKEYVHNYLTDDNMRNCSLILNKSYEYINPSGDTELIGLDGTPVVEGSGDTNGQIGVINIGGPEYEKQLQKCLLYIVTASGKNTAQAYERTSPYTAAYKLPVEMRGFLNETFKWRLLSAESPPEKSMVFGAPHLVRLMIKMPMFLNASPISNKKLEDLLPHLDAFINYLENHREWFDRENFVNSTALPQEDLQRELLDSLDGIAA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of MSL3_DROME !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MSL3_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MSL3_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MSL3_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JIL1_DROME	JIL-1	physical	10831604
MSL1_DROME	msl-1	physical	10619853
MSL1_DROME	msl-1	physical	21217699
H31T_HUMAN	HIST3H3	physical	20943666
MOF_DROME	mof	physical	19029895
MSL1_DROME	msl-1	physical	15988010
SGG_DROME	sgg	physical	24990964
MOF_DROME	mof	physical	16543150
MOF_DROME	mof	physical	24990964
MOF_DROME	mof	physical	26831069
MOF_DROME	mof	physical	15141166
MOF_DROME	mof	physical	21217699
MSL2_DROME	msl-2	physical	16543150
MSL2_DROME	msl-2	physical	24990964
MSL2_DROME	msl-2	physical	26831069
MSL2_DROME	msl-2	physical	15141166
MSL2_DROME	msl-2	physical	23989663
MSL2_DROME	msl-2	physical	9736618
MSL2_DROME	msl-2	physical	25694028
WDR82_DROME	Wdr82	physical	24990964
NU160_DROME	Nup160	physical	16543150
MSL1_DROME	msl-1	physical	16543150
MSL1_DROME	msl-1	physical	24990964
MSL1_DROME	msl-1	physical	26831069
MSL1_DROME	msl-1	physical	15141166
MSL1_DROME	msl-1	physical	23989663
MSL1_DROME	msl-1	physical	9736618
TOP2_DROME	Top2	physical	23989663
MLE_DROME	mle	physical	24990964
MLE_DROME	mle	physical	26831069
MLE_DROME	mle	physical	23989663
TPR_DROME	Mtor	physical	16543150
JIL1_DROME	JIL-1	physical	24990964
JIL1_DROME	JIL-1	physical	26831069
TBA1_DROME	alphaTub84B	physical	16543150
HCF_DROME	Hcf	physical	24990964

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MSL3_DROME

Related Literatures of Post-Translational Modification