MSL2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MSL2_DROME
• UniProt AC: P50534
• Protein Name: E3 ubiquitin-protein ligase msl-2
• Gene Name: msl-2
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 773
• Subcellular Localization: Nucleus. Chromosome. Msl-1 and msl-2 colocalize to many sites on the male X chromosome.
• Protein Description: The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-2 is required for translation and/or stability of msl-1 in males. In complex with msl-1, acts as an E3 ubiquitin ligase that promotes ubiquitination of histone H2B..
• Protein Sequence: MAQTAYLKVTRIAMRSASNLSKRRVEELNSGLGELRQLLSCVVCCQLLVDPYSPKGKRCQHNVCRLCLRGKKHLFPSCTQCEGCSDFKTYEENRMMAAQLLCYKTLCVHLLHSALFGELAGMRPQVARELVPRIKLPPKTTQEFIREGSNISDTFDIFLPQPDLPFLKDMPTSLPAETPPTSAVTTPELPYDHHLNISDIEAEAAATAEQGHFSPLPLLPTGSRMGMLSHAGQIVIATESSESGFMDQAWTDQVDLSGTVSVSKYTNSGNNFAVSYVMPTSATTKFDPQELQIGQVVQMADSTQLAVLAAVEETVETSTQLTVLSTTVEETVETSTQLEVLTSAEEPNEISDQLANLQVEESDEALVEETVEEAEGTSIPSEVVAEHMEEDQHLDVHTSQSPTQTEMEEAVEEHVATKTQLGHVQTELQDAESLQKDFEDAKAAAEEAKEKEKDLHAISAELQKEDSDEPTLKRKRTRTLKASQAAKIEPVPSEVKTKVQSGKGALRRIRGKDKEEKVKPPKPKCRCGISGSSNTLTTCRNSRCPCYKSYNSCAGCHCVCCKNPHKEDYVESDEDDDLEDFEMPKDVPEPMTQSEEPVVAEPRQEENSMAPPDSSAPISLVPLNNLQQSQHPLVLVQNEKGEYQGFNIFQGSKPLDPVTVGFTIRVQLQHTDGFGSLPQYAYIMPTIDPPNPPAPSLSPPPPPAPDREVIEPPAKKFRTSRTRRGRANFSALDTVDELVSGGSRSNSAAGDRSSATDNAHSLFEEIMSGSDDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	MRSASNLSKRRVEEL HHHCCHHHHHHHHHH	28.50	22817900
549	Phosphorylation	SRCPCYKSYNSCAGC CCCCCCCCCCCCCCC	11.76	22817900
550	Phosphorylation	RCPCYKSYNSCAGCH CCCCCCCCCCCCCCE	13.62	22817900
552	Phosphorylation	PCYKSYNSCAGCHCV CCCCCCCCCCCCEEE	9.34	22817900
572	Phosphorylation	HKEDYVESDEDDDLE CHHHCCCCCCCCCHH	35.93	19429919
740	Phosphorylation	DTVDELVSGGSRSNS HCHHHHHHCCCCCCC	50.49	29892262
743	Phosphorylation	DELVSGGSRSNSAAG HHHHHCCCCCCCCCC	35.74	19429919
761	Phosphorylation	SATDNAHSLFEEIMS CCCCHHHHHHHHHHC	32.13	19429919
768	Phosphorylation	SLFEEIMSGSDDL-- HHHHHHHCCCCCC--	40.58	19429919
770	Phosphorylation	FEEIMSGSDDL---- HHHHHCCCCCC----	22.20	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MSL2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MSL2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MSL2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MOF_DROME	mof	physical	16179989
JIL1_DROME	JIL-1	physical	10831604
H2B2E_HUMAN	HIST2H2BE	physical	21726816
MSL2_DROME	msl-2	physical	23084835
MSL1_DROME	msl-1	physical	23084835
UB2D1_HUMAN	UBE2D1	physical	23084835
MSL2_DROME	msl-2	physical	23084834
MSL1_DROME	msl-1	physical	23084834
MOF_DROME	mof	physical	23084834
MSL3_DROME	msl-3	physical	23084834
MSL1_DROME	msl-1	genetic	12807777
AGO2_DROME	AGO2	genetic	22554892
SPT5H_DROME	Spt5	genetic	23209435
MOF_DROME	mof	physical	10594033
MOF_DROME	mof	physical	23084835
MSL1_DROME	msl-1	physical	10594033
MSL1_DROME	msl-1	physical	7781064
MSL1_DROME	msl-1	physical	9736618
MSL3_DROME	msl-3	physical	10594033
MSL3_DROME	msl-3	physical	23084835
MSL3_DROME	msl-3	physical	9736618
JIL1_DROME	JIL-1	physical	25694028
PSMD4_DROME	Rpn10	physical	23084835

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.