HCF_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HCF_DROME
• UniProt AC: Q9V4C8
• Protein Name: Host cell factor
• Gene Name: Hcf {ECO:0000312|EMBL:AAF59349.2}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1500
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in control of the cell cycle..
• Protein Sequence: MEGSDFVDPAFSSGERISASDLNSEHIIQAENHSFANRISMDMDVPDGHQLDSNLTGFRWKRVLNPTGPQPRPRHGHRAINIKELMVVFGGGNEGIVDELHVYNTVTNQWYVPVLKGDVPNGCAAYGFVVEGTRMFVFGGMIEYGKYSNELYELQATKWEWRKMYPESPDSGLSPCPRLGHSFTMVGEKIFLFGGLANESDDPKNNIPKYLNDLYILDTRGVHSHNGKWIVPKTYGDSPPPRESHTGISFATKSNGNLNLLIYGGMSGCRLGDLWLLETDSMTWSKPKTSGEAPLPRSLHSSTMIGNKMYVFGGWVPLVINDSKSTTEREWKCTNTLAVLDLETMTWENVTLDTVEENVPRARAGHCAVGIQSRLYVWSGRDGYRKAWNNQVCCKDLWYLEVSKPLYAVKVALVRASTHALELSWTATTFAAAYVLQIQKIEQPLNTSSKLLSNNIVQQGTPTSAETSGINISANRSGSALGLGVEATSTVLKLEKESLQLSGCQPETNVQPSVNDLLQSMSQPSSPASRADKDPLSSGGGTTFNLSTSVASVHPQISVISSTAAVTGNDTASPSGAINSILQKFRPVVTAVRTSTTTAVSIATSTSDPLSVRVPSTMSANVVLSSSSSTLRIVPSVTASHSLRIASSQASGNNCRSSSAINILKTALPNVAVQSQPTSSTTTSIGGKQYFIQKPLTLAPNVQLQFVKTSGGMTVQTLPKVNFTASKGTPPHGISIANPHLASGITQIQGSTVPGSQIQKPIVSGNVLKLVSPHTMAGGKLIMKNSNILQMGKVTPNVMGGKPAFVITNKQGTPLGNQQIIIVTTGGNVRSVPTSTVMTSAGGSASGTNIVSIVNSTSTTPSPLQALSGQKTLISNQSGVKMLRNISSVQASSSMAFGQKQSGTPIHQKTALYIGGKAVTVMSTNTSMAASGNKVMVLPGTSSNNSPATTTALSARKSFVFNAGGSPRTVTLATKSINAKSIPQSQPVTETNNHSVATIKDTDPMDDIIEQLDGAGDLLKLSESEGQHGSEENENNGENATSSSASALFTGGDTAGPSRAQNPIVMEHPVDIIEDVSGVSSTTDVNETAIVSGDTIESLKMSEKENDDVKSMGEKSILSDDCHQPTTSETEAATILTTIKSAEALVLETAEIRKDHTGCTIGSLKENQDENKKFKQRQESSPSQNIHQFQNVDGSQLEALASAALLQAATSDTTALALKELIERPESETNTRSSNIAEIQQNNVQSTLAVVVPNTSQNENQKWHTVGVFKDLSHTVTSYIDSNCISDSFFDGIDVDNLPDFSKFPRTNLEPGTAYRFRLSAINSCGRGEWGEISSFKTCLPGFPGAPSAIKISKDVKEGAHLTWEPPPAQKTKEIIEYSVYLAVKPTAKDKALSTPQLAFVRVYVGAANQCTVPNASLSNAHVDCSNKPAIIFRIAARNQKGYGPATQVRWLQDPAAAKQHTPTVTPNLKRGPEKSTIGSSNIANTFCSPHKRGRNGLHD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	HSFANRISMDMDVPD CCCCCCCCCCCCCCC	12.90	19429919
461	Phosphorylation	NNIVQQGTPTSAETS CCCCCCCCCCCCCCC	21.03	30478224
477	Phosphorylation	INISANRSGSALGLG CEEEECCCCCCCCCC	36.59	19060867
479	Phosphorylation	ISANRSGSALGLGVE EEECCCCCCCCCCCE	22.90	29892262
522	Phosphorylation	NDLLQSMSQPSSPAS HHHHHHCCCCCCCCH	44.16	22668510
525	Phosphorylation	LQSMSQPSSPASRAD HHHCCCCCCCCHHCC	41.12	22668510
526	Phosphorylation	QSMSQPSSPASRADK HHCCCCCCCCHHCCC	31.04	20450229
642	Phosphorylation	PSVTASHSLRIASSQ CEEEECCEEEEECCC	19.49	21082442
688	Acetylation	TTTSIGGKQYFIQKP CCCEECCEEEEEECC	36.29	21791702
690	Acetylation	TSIGGKQYFIQKPLT CEECCEEEEEECCCE	13.21	-
780	Acetylation	PHTMAGGKLIMKNSN CCHHCCCEEEEECCC	33.64	21791702
782	Acetylation	TMAGGKLIMKNSNIL HHCCCEEEEECCCEE	4.15	-
795	Phosphorylation	ILQMGKVTPNVMGGK EECCCCCCCCCCCCC	16.78	21082442
802	Acetylation	TPNVMGGKPAFVITN CCCCCCCCCEEEEEC	27.69	21791702
865	Acetylation	STTPSPLQALSGQKT CCCCCHHHHHCCCCE	43.57	-
881	Acetylation	ISNQSGVKMLRNISS ECCCHHHHHHHHCCC	35.42	21791702
887	Phosphorylation	VKMLRNISSVQASSS HHHHHHCCCEECCCC	28.18	21082442
913	Phosphorylation	IHQKTALYIGGKAVT CCCEEEEEECCEEEE	8.61	22668510
931	Phosphorylation	TNTSMAASGNKVMVL CCCCCCCCCCEEEEE	33.10	22668510
941	Acetylation	KVMVLPGTSSNNSPA EEEEECCCCCCCCCC	27.35	-
946	Phosphorylation	PGTSSNNSPATTTAL CCCCCCCCCCCHHCH	21.84	21082442
957	Acetylation	TTALSARKSFVFNAG HHCHHHCCEEEECCC	48.22	21791702
958	Phosphorylation	TALSARKSFVFNAGG HCHHHCCEEEECCCC	22.53	19429919
959	Acetylation	ALSARKSFVFNAGGS CHHHCCEEEECCCCC	9.02	-
964	Acetylation	KSFVFNAGGSPRTVT CEEEECCCCCCCEEE	37.91	-
966	Phosphorylation	FVFNAGGSPRTVTLA EEECCCCCCCEEEEE	15.42	21082442
975	Acetylation	RTVTLATKSINAKSI CEEEEEECCCCCCCC	43.67	21791702
980	Acetylation	ATKSINAKSIPQSQP EECCCCCCCCCCCCC	44.42	21791702
1126	Phosphorylation	SDDCHQPTTSETEAA CCCCCCCCCCHHHHH	36.06	18327897
1141	Phosphorylation	TILTTIKSAEALVLE HHHHHHHCCCCHHHE	27.73	29892262
1195	Phosphorylation	QFQNVDGSQLEALAS EEECCCHHHHHHHHH	27.42	30478224
1202	Phosphorylation	SQLEALASAALLQAA HHHHHHHHHHHHHHH	18.22	30478224
1480	Phosphorylation	PEKSTIGSSNIANTF CCCCCCCCCHHHCCC	19.16	23607784
1481	Phosphorylation	EKSTIGSSNIANTFC CCCCCCCCHHHCCCC	27.35	23607784
1486	Phosphorylation	GSSNIANTFCSPHKR CCCHHHCCCCCCCCC	19.59	23607784
1489	Phosphorylation	NIANTFCSPHKRGRN HHHCCCCCCCCCCCC	26.33	12609738

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HCF_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HCF_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HCF_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASH2_DROME	ash2	physical	17466076
MYC_DROME	dm	physical	20937797
WDS_DROME	wds	physical	22036573
PC_DROME	Pc	genetic	22174740
MED13_DROME	skd	genetic	22174740
TAD2A_DROME	Ada2a	physical	16428443

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-477; SER-958; SER-966;THR-1126 AND SER-1489, AND MASS SPECTROMETRY.
PubMed: 18327897