ASH2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASH2_DROME
• UniProt AC: Q94545
• Protein Name: Set1/Ash2 histone methyltransferase complex subunit ASH2 {ECO:0000303|PubMed:21694722}
• Gene Name: ash2 {ECO:0000312|EMBL:AAC47328.2, ECO:0000312|FlyBase:FBgn0000139}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 556
• Subcellular Localization: Nucleus . Chromosome . Accumulates on salivary gland polytene chromosomes.
• Protein Description: Transcriptional regulator. Regulates a number of genes involved in wing development including activation of net and bs and repression of rho and kni and controls vein-intervein patterning during wing development. Required for correct expression of a number of homeotic genes including Scr in the first leg imaginal disk and Ubx in the third leg imaginal disk and haltere disks. Required for stabilization of the histone-lysine N-methyltransferase trr and for trimethylation of 'Lys-4' of histone H3. Plays a role in maintenance of transcriptionally active chromatin through down-regulation of histone H1 hyperphosphorylation..
• Protein Sequence: MEDSQMDTSSPTESSSEVNFTAEEDKSQETRSAAGVCYCGKERNLNIVELLCATCSRWVHETCVSYQLGKGKLLPFITNYVFVCKNCSASGLESFRKSQATISQMCHCAIANMQQAASRDGRRQIQFSKDKEIIPYIEQYWEAMTTMPRRLTQSWYSTVQRSLVKDVQTLFTYEEHAEHGAMYGLFHQDLRIIKPNYESMSKSGALRLTDDGYTQASLSKNNRQKRKFPGTDSGPTGKKGRPSSDITANVKLPPHGYPLEHPFNKDGYRYILAEPDPHAPFRQEFDESSDWAGKPIPGWLYRILVPHSVLLALHDRAPQLKISEDRLAVTGERGYCMVRATHSVNRGCWYFEVTIEEMPDGAATRLGWGREYGNLQAPLGYDKFGYSWRSRKGTKFTESHGKHYSDAYVEGDTLGFLIELPEEASLDYLPNTFKDRPLVKFKSHLYYEDKDKITETLKNLHILQGSRIEFFKNGQSQGVAFEDIYAGSYFPAISIHKSATVSVNFGPAFKYPEVLVEHKAKGMHDRVEELITEQCLADTLYLTEHDGRLRLDNMGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
243	Phosphorylation	TGKKGRPSSDITANV CCCCCCCCCCCEECC		19429919
244	Phosphorylation	GKKGRPSSDITANVK CCCCCCCCCCEECCC		19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASH2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASH2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASH2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HCF_DROME	Hcf	physical	17466076
DPY30_DROME	Dpy-30L1	physical	22036573
SETB1_DROME	egg	physical	22048023
MYC_DROME	dm	genetic	17311883
EGFR_DROME	Egfr	genetic	15371308
SRF_DROME	bs	genetic	15371308
TRR_DROME	trr	physical	21875999
CXXC1_DROME	Cfp1	physical	21875999
SET1_DROME	Set1	physical	21875999
SET1_DROME	Set1	physical	22048023
WDR82_DROME	Wdr82	physical	21875999
DPY30_DROME	Dpy-30L1	physical	21875999
RBBP5_DROME	Rbbp5	physical	21875999
TRX_DROME	trx	physical	21875999
TRX_DROME	trx	physical	23197473
HCF_DROME	Hcf	physical	21875999
WDS_DROME	wds	physical	21875999

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.