SET1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SET1_DROME
• UniProt AC: Q5LJZ2
• Protein Name: Histone-lysine N-methyltransferase SETD1 {ECO:0000250|UniProtKB:Q9UPS6}
• Gene Name: Set1 {ECO:0000312|EMBL:EAL24598.1, ECO:0000312|FlyBase:FBgn0040022}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1641
• Subcellular Localization: Nucleus . Chromosome . Colocalizes with di- and trimethylated H3 'Lys-4' and with phosphorylated RNA polymerase II at transcriptional puffs on polytene chromosomes.
• Protein Description: Catalytic component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and is the main di- and trimethyltransferase throughout development. Set1-dependent trimethylation regulates chromatin changes at active promoters that ensure optimal RNA polymerase II release into productive elongation, thereby contributing to optimal transcription..
• Protein Sequence: MQDVRNINLVNNSSNSHDSSLANSKMPRNFKLLSDPQLVKCGTRLYRYDGLMPGDPSYPTITPRDPRNPLIRIRARAVEPLMLLIPRFVIDSDYVGQPPAVEVTIVNLNDNIDKQFLASMLDKCGTSDEINIYHHPITNKHLGIARIVFDSTKGARQFVEKYNQKSVMGKILDVFCDPFGATLKKSLESLTNSVAGKQLIGPKVTPQWTFQQAALEDTEFIHGYPEKNGEHIKDIYTTQTNHEIPNRSRDRNWNRDKERERDRHFKERSRHSSERSYDRDRGMRENVGTSIRRRRTFYRRRSSDISPEDSRDILIMTRERSRDSDSRPRDYCRSRERESFRDRKRSHEKGRDQPREKREHYYNSSKDREYRGRDRDRSAEIDQRDRGSLKYCSRYSLHEYIETDVRRSSNTISSYYSASSLPIASHGFNSCSFPSIENIKTWSDRRAWTAFQPDFHPVQPPPPPPEEIDNWDEEEHDKNSIVPTHYGCMAKLQPPVPSNVNFATKLQSVTQPNSDPGTVDLDTRIALIFKGKTFGNAPPFLQMDSSDSETDQGKPEVFSDVNSDSNNSENKKRSCEKNNKVLHQPNEASDISSDEELIGKKDKSKLSLICEKEVNDDNMSLSSLSSQEDPIQTKEGAEYKSIMSSYMYSHSNQNPFYYHASGYGHYLSGIPSESASRLFSNGAYVHSEYLKAVASFNFDSFSKPYDYNKGALSDQNDGIRQKVKQVIGYIVEELKQILKRDVNKRMIEITAFKHFETWWDEHTSKARSKPLFEKADSTVNTPLNCIKDTSYNEKNPDINLLINAHREVADFQSYSSIGLRAAMPKLPSFRRIRKHPSPIPTKRNFLERDLSDQEEMVQRSDSDKEDSNVEISDTARSKIKGPVPIQESDSKSHTSGLNSKRKGSASSFFSSSSSSTSSEAEYEAIDCVEKARTSEEDSPRGYGQRNLNQRTTTIRNRNLVGTMDVINVRNLCSGSNEFKKENVTKRTKKNIYSDTDEDNDRTLFPALKEKNISTILSDLEEISKDSCIGLDENGIEPTILRKIPNTPKLNEECRRSLTPVPPPGYNEEEIKKKVDCKQKPSFEYDRIYSDSEEEKEYQERRKRNTEYMAQMEREFLEEQEKRIEKSLDKNLQSPNNIVKNNNSPRNKNDETRKTAISQTRSCFESASKVDTTLVNIISVENDINEFGPHEEGDVLTNGCNKMYTNSKGKTKRTQSPVYSEGGSSQASQASQVALEHCYSLPPHSVSLGDYPSGKVNETKNILKREAENIAIVSQMTRTGPGRPRKDPICIQKKKRDLAPRMSNVKSKMTPNGDEWPDLAHKNVHFVPCDMYKTRDQNEEMVILYTFLTKGIDAEDINFIKMSYLDHLHKEPYAMFLNNTHWVDHCTTDRAFWPPPSKKRRKDDELIRHKTGCARTEGFYKLDVREKAKHKYHYAKANTEDSFNEDRSDEPTALTNHHHNKLISKMQGISREARSNQRRLLTAFGSMGESELLKFNQLKFRKKQLKFAKSAIHDWGLFAMEPIAADEMVIEYVGQMIRPVVADLRETKYEAIGIGSSYLFRIDMETIIDATKCGNLARFINHSCNPNCYAKVITIESEKKIVIYSKQPIGINEEITYDYKFPLEDEKIPCLCGAQGCRGTLN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
302	Phosphorylation	RTFYRRRSSDISPED HHHHHHCCCCCCHHH		19429919
303	Phosphorylation	TFYRRRSSDISPEDS HHHHHCCCCCCHHHH		19429919
306	Phosphorylation	RRRSSDISPEDSRDI HHCCCCCCHHHHCCE		19429919
310	Phosphorylation	SDISPEDSRDILIMT CCCCHHHHCCEEEEE		19429919
378	Phosphorylation	RGRDRDRSAEIDQRD CCCCCCCCCCCCHHH		19429919
530	Acetylation	TRIALIFKGKTFGNA CEEEEEECCCCCCCC		21791702
589	Phosphorylation	LHQPNEASDISSDEE CCCCCCHHCCCCCHH		19429919
592	Phosphorylation	PNEASDISSDEELIG CCCHHCCCCCHHHCC		19429919
593	Phosphorylation	NEASDISSDEELIGK CCHHCCCCCHHHCCC		19429919
604	Phosphorylation	LIGKKDKSKLSLICE HCCCCCHHHHEEEEE		22817900
607	Phosphorylation	KKDKSKLSLICEKEV CCCHHHHEEEEEEEE		22817900
620	Phosphorylation	EVNDDNMSLSSLSSQ EECCCCCCHHHCCCC		19429919
622	Phosphorylation	NDDNMSLSSLSSQED CCCCCCHHHCCCCCC		19429919
623	Phosphorylation	DDNMSLSSLSSQEDP CCCCCHHHCCCCCCC		19429919
625	Phosphorylation	NMSLSSLSSQEDPIQ CCCHHHCCCCCCCCC		19429919
626	Phosphorylation	MSLSSLSSQEDPIQT CCHHHCCCCCCCCCC		19429919
633	Phosphorylation	SQEDPIQTKEGAEYK CCCCCCCCCCHHHHH		19429919
837	Phosphorylation	RRIRKHPSPIPTKRN HHHHCCCCCCCCCCC		19429919
851	Phosphorylation	NFLERDLSDQEEMVQ CHHHCCCCCHHHHHH		19429919
860	Phosphorylation	QEEMVQRSDSDKEDS HHHHHHCCCCCCCCC		22817900
862	Phosphorylation	EMVQRSDSDKEDSNV HHHHCCCCCCCCCCC		22817900
867	Phosphorylation	SDSDKEDSNVEISDT CCCCCCCCCCCCCHH		22817900
933	Phosphorylation	DCVEKARTSEEDSPR HHHHHHCCCCCCCCC		25749252
934	Phosphorylation	CVEKARTSEEDSPRG HHHHHCCCCCCCCCC		25749252
938	Phosphorylation	ARTSEEDSPRGYGQR HCCCCCCCCCCCCCC		25749252
993	Phosphorylation	RTKKNIYSDTDEDND HHHCCCCCCCCCCCC		19429919
995	Phosphorylation	KKNIYSDTDEDNDRT HCCCCCCCCCCCCCC		25749252
1013	Phosphorylation	ALKEKNISTILSDLE HHHHCCHHHHHHCHH		19429919
1014	Phosphorylation	LKEKNISTILSDLEE HHHCCHHHHHHCHHH		19429919
1017	Phosphorylation	KNISTILSDLEEISK CCHHHHHHCHHHHCC		19429919
1023	Phosphorylation	LSDLEEISKDSCIGL HHCHHHHCCCCCCCC		19429919
1046	Phosphorylation	ILRKIPNTPKLNEEC HHHCCCCCCCCCHHH		27626673
1056	Phosphorylation	LNEECRRSLTPVPPP CCHHHHHCCCCCCCC		19429919
1058	Phosphorylation	EECRRSLTPVPPPGY HHHHHCCCCCCCCCC		19429919
1089	Phosphorylation	FEYDRIYSDSEEEKE CCCCCCCCCCHHHHH		19429919
1091	Phosphorylation	YDRIYSDSEEEKEYQ CCCCCCCCHHHHHHH		19429919
1133	Phosphorylation	SLDKNLQSPNNIVKN HHHHCCCCCCCCCCC		19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SET1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SET1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SET1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
H15_DROME	H15	physical	25242320

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.