dbPTM

MYC_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MYC_DROME
UniProt AC	Q9W4S7
Protein Name	Myc protein {ECO:0000312\|FlyBase:FBgn0262656}
Gene Name	Myc {ECO:0000303\|PubMed:8929412, ECO:0000312\|FlyBase:FBgn0262656}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	717
Subcellular Localization	Nucleus . Cytoplasm . Transolcation from the cytoplasm to the nucleus may be promoted by the TORC2 complex (Lst8 and rictor).
Protein Description	Participates in the regulation of gene transcription. [PubMed: 8929412]
Protein Sequence	MALYRSDPYSIMDDQLFSNISIFDMDNDLYDMDKLLSSSTIQSDLEKIEDMESVFQDYDLEEDMKPEIRNIDCMWPAMSSCLTSGNGNGIESGNSAASSYSETGAVSLAMVSGSTNLYSAYQRSQTTDNTQSNQQHVVNSAENMPVIIKKELADLDYTVCQKRLRLSGGDKKSQIQDEVHLIPPGGSLLRKRNNQDIIRKSGELSGSDSIKYQRPDTPHSLTDEVAASEFRHNVDLRACVMGSNNISLTGNDSDVNYIKQISRELQNTGKDPLPVRYIPPINDVLDVLNQHSNSTGGQQQLNQQQLDEQQQAIDIATGRNTVDSPPTTGSDSDSDDGEPLNFDLRHHRTSKSGSNASITTNNNNSNNKNNKLKNNSNGMLHMMHITDHSYTRCNDMVDDGPNLETPSDSDEEIDVVSYTDKKLPTNPSCHLMGALQFQMAHKISIDHMKQKPRYNNFNLPYTPASSSPVKSVANSRYPSPSSTPYQNCSSASPSYSPLSVDSSNVSSSSSSSSSQSSFTTSSSNKGRKRSSLKDPGLLISSSSVYLPGVNNKVTHSSMMSKKSRGKKVVGTSSGNTSPISSGQDVDAMDRNWQRRSGGIATSTSSNSSVHRKDFVLGFDEADTIEKRNQHNDMERQRRIGLKNLFEALKKQIPTIRDKERAPKVNILREAAKLCIQLTQEEKELSMQRQLLSLQLKQRQDTLASYQMELNESRSVSG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
217	Phosphorylation	IKYQRPDTPHSLTDE CCCCCCCCCCCCCHH	26.11	18327897
220	Phosphorylation	QRPDTPHSLTDEVAA CCCCCCCCCCHHHHH	33.88	18327897
461	Phosphorylation	YNNFNLPYTPASSSP CCCCCCCCCCCCCCC	28.64	25749252
560	Phosphorylation	VTHSSMMSKKSRGKK CCHHHHHCCCCCCCC	28.43	22817900
571	Phosphorylation	RGKKVVGTSSGNTSP CCCCEECCCCCCCCC	14.22	19429919
572	Phosphorylation	GKKVVGTSSGNTSPI CCCEECCCCCCCCCC	30.25	19429919
573	Phosphorylation	KKVVGTSSGNTSPIS CCEECCCCCCCCCCC	35.58	19429919
576	Phosphorylation	VGTSSGNTSPISSGQ ECCCCCCCCCCCCCC	39.13	19429919
577	Phosphorylation	GTSSGNTSPISSGQD CCCCCCCCCCCCCCC	25.00	19429919
580	Phosphorylation	SGNTSPISSGQDVDA CCCCCCCCCCCCCCC	31.62	19429919
581	Phosphorylation	GNTSPISSGQDVDAM CCCCCCCCCCCCCCC	40.99	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MYC_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MYC_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MYC_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
THOC7_DROME	thoc7	physical	14605208
OCTB2_DROME	Octbeta2R	physical	14605208
ELG_DROME	Ets97D	physical	14605208
MAX_DROME	Max	physical	14605208
GROU_DROME	gro	physical	17898168
UBE2S_DROME	CG8188	physical	19364825
KDM5_DROME	lid	physical	17311883
ASH2_DROME	ash2	physical	17311883
BRM_DROME	brm	physical	17311883
AST4_DROME	sc	genetic	21220321
SQH_DROME	sqh	genetic	26287461
SISA_DROME	sisA	genetic	21220321
HEP_DROME	hep	genetic	15066286
RUNT_DROME	run	genetic	21220321
RPA2_DROME	RpI135	genetic	15723055
DECA_DROME	dpp	genetic	15066287
KDM5_DROME	lid	genetic	17311883
KDM5_DROME	lid	genetic	21124823
REF2P_DROME	ref(2)P	genetic	23950728
DIA_DROME	dia	genetic	26287461
LTV1_DROME	CG7686	genetic	25858587
SUZ2_DROME	Su(z)2	genetic	17311883
TFDP_DROME	Dp	genetic	15084262
ASX_DROME	Asx	genetic	17311883
CADE_DROME	shg	genetic	26287461
YAP1_DROME	yki	genetic	22069188
PUF68_DROME	pUf68	genetic	14993190
FBXW7_DROME	ago	genetic	17311883
FBXW7_DROME	ago	genetic	24173801
FBXW7_DROME	ago	genetic	15182669
ERCC3_DROME	hay	genetic	26074141
FLOWR_DROME	fwe	genetic	20627080
BRM_DROME	brm	genetic	17311883
DIAP1_DROME	th	genetic	26287461
RUVB2_DROME	rept	genetic	16087886
MAX_DROME	Max	genetic	19165923
E2AK3_DROME	PEK	genetic	23950728
CNC_DROME	cnc	genetic	23950728
ASH2_DROME	ash2	genetic	17311883
ASH2_DROME	ash2	genetic	20937797
ELG_DROME	Ets97D	genetic	19742324
HCF_DROME	Hcf	genetic	20937797
RL8_DROME	RpL8	genetic	18957936
RUVB1_DROME	pont	genetic	16087886
INSL5_DROME	Ilp5	genetic	23608455
LSG1_DROME	Ns3	physical	27626673
RSSA_DROME	sta	physical	27626673
LVA_DROME	lva	physical	27626673
MLC2_DROME	Mlc-c	physical	27626673
RL7A_DROME	RpL7A	physical	27626673
RL17_DROME	RpL17	physical	27626673
RS6_DROME	RpS6	physical	27626673
HSP7C_DROME	Hsc70-3	physical	27626673
HANG_DROME	hang	physical	27626673
FLII_DROME	fliI	physical	27626673
RLA1_DROME	RpLP1	physical	27626673
KDM5_DROME	lid	physical	21124823
RS23_DROME	RpS23	physical	27626673
RLA2_DROME	RpLP2	physical	27626673
RL18A_DROME	RpL18A	physical	27626673
ACT3_DROME	Act57B	physical	27626673
RS16_DROME	RpS16	physical	27626673
RL19_DROME	RpL19	physical	27626673
SPTCA_DROME	alpha-Spec	physical	27626673
RL28_DROME	RpL28	physical	27626673
SARM1_DROME	Ect4	physical	27626673
RS17_DROME	RpS17	physical	27626673
RS9_DROME	RpS9	physical	27626673
R10AB_DROME	RpL10Ab	physical	27626673
MAX_DROME	Max	physical	27626673
MAX_DROME	Max	physical	19165923
VATE_DROME	Vha26	physical	27626673
RL13A_DROME	RpL13A	physical	27626673
HYD_DROME	hyd	physical	27626673
TCPA_DROME	T-cp1	physical	27626673
RL4_DROME	RpL4	physical	27626673
RS7_DROME	RpS7	physical	27626673
HCF_DROME	Hcf	physical	20937797
GAWKY_DROME	gw	physical	27626673
KCC2A_DROME	CaMKII	physical	27626673
CSK2A_DROME	CkIIalpha	physical	27626673
ANKHM_DROME	mask	physical	27626673
LARP_DROME	larp	physical	27626673
CAPR1_DROME	Capr	physical	27626673

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MYC_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-217 AND SER-220, ANDMASS SPECTROMETRY.	18327897 [Abstract]