E2AK3_DROME - dbPTM
E2AK3_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID E2AK3_DROME
UniProt AC Q9NIV1
Protein Name Eukaryotic translation initiation factor 2-alpha kinase
Gene Name PEK
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1162
Subcellular Localization Endoplasmic reticulum membrane
Single-pass type I membrane protein.
Protein Description Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis..
Protein Sequence MQDDLDGIVRHRRRSLSFLQIVTLTMAGLVAFDPAQVLAGHPTTDSELQTAGSPRPPGLEHCVDQEERRVARRLLYISTLDGRLSALDIAKSGKLRWSVPTGPGPLISSSIHRLELTNNGQFVRMIPSLSGGIYKFDGDSIDPIPITAEHLLSSSAKFSDDLVISGGKETRSYGVSVRTGQLLYECSLNGCVNSTEEGLAIDDTIREPDEEDQLEDGEQLRDEAGYIVRHDPLLDDVIIVRRQTQTVRAVESRTGVERWNFSVGQHELDLVRPSECQLQPRDELELAVLDVDIKVVVPEGIICAFSKSEPQTMLWKYKFDHPIVSAWNTNADDELQPIDLFSSAQWLWDQDENDTELPNAPQSPPSIYLGMYDKQLYIQESIRLRQEIMDQTKVYQQLTGDTSLMPRIPWKPISASSKSLVIFRKDQEDPEMIAEGAVAQGGELVPYDDENFAVAAQSVLNASEFVNGNGFYFYTTGDLNGPQECSTQNNPTDLPAITAPTSPTNATSEGTEATGNHSVNDDLGFSLDDIDAPVKVVILSLWFWWKEIVVIAFTSAVILNIFMGQRNQRVEREYLVIERHVPVQTAIEATEASTQALLGPVVPMQRPGNRFSFPPGQANQRTISESTTHSGEHYTSRFQSDFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQRVLREARTLASCEHHNIVRYFHSWTETPPTGWQEEEDRKLLAHELSTSIQIETPDDSTMPSLTEQLKEKRQQQLLSWVSDAANSTACSHDFHLPGESSLKNIREEYDYDEEEDSLIEFRSESQSAALRAEEEDDTDDDYEEDEEQQGDHEKRHRSSVSIDIHSASFDLKNINYSQHQLVSNSFQIESVRPKSSGSDDANDDNKARRKPLTLALAQNHNNNQNGSQPTPSSATILNGTVAKPSKVYLYIQMQLCRKESLRDWLRDNRSETRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDGQIKIGDFGLVTDMADIPNLVAKCGDQSGLPSCARHTQQVGTHLYMSPEQLLGQHYDYKVDIYSLGLIFFELHVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQQYDLLQQMLSAQPEQRPQTKQLKSQLRNILQLPHLLSEGQSEQAELAERARRLSRSRTFSSSSEPHQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
193N-linked_GlycosylationCSLNGCVNSTEEGLA
EECCCCCCCCCCCCC		47.49-
260N-linked_GlycosylationRTGVERWNFSVGQHE
CCCCCEEEEECCCCC		26.07-
353N-linked_GlycosylationWLWDQDENDTELPNA
CCCCCCCCCCCCCCC		70.56-
461N-linked_GlycosylationVAAQSVLNASEFVNG
HHHHHHHHHHHCCCC		38.99-
505N-linked_GlycosylationTAPTSPTNATSEGTE
CCCCCCCCCCCCCCC		44.60-
516N-linked_GlycosylationEGTEATGNHSVNDDL
CCCCCCCCCCCCCCC		21.65-
622PhosphorylationPGQANQRTISESTTH
CCCCCCCEECCCCCC		21.0619429919
624PhosphorylationQANQRTISESTTHSG
CCCCCEECCCCCCCC		25.5319429919
626PhosphorylationNQRTISESTTHSGEH
CCCEECCCCCCCCCC		31.6419429919
627PhosphorylationQRTISESTTHSGEHY
CCEECCCCCCCCCCC		25.2019429919
628PhosphorylationRTISESTTHSGEHYT
CEECCCCCCCCCCCC		24.2722668510
630PhosphorylationISESTTHSGEHYTSR
ECCCCCCCCCCCCHH		43.7319429919
797PhosphorylationDYDEEEDSLIEFRSE
CCCHHCCCCEEECCH		34.2319429919
803PhosphorylationDSLIEFRSESQSAAL
CCCEEECCHHHHHHH		47.0919429919
805PhosphorylationLIEFRSESQSAALRA
CEEECCHHHHHHHHH		30.5919429919
807PhosphorylationEFRSESQSAALRAEE
EECCHHHHHHHHHHH		25.4519429919
818PhosphorylationRAEEEDDTDDDYEED
HHHHCCCCCCCCCHH		54.3622817900
848PhosphorylationSIDIHSASFDLKNIN
EEEEEECCCCCCCCC		23.4722668510
1028PhosphorylationLPSCARHTQQVGTHL
CCCHHHHHCCCCCEE		18.3618327897
1155PhosphorylationLSRSRTFSSSSEPHQ
HHHCCCCCCCCCCCC		28.7919429919
1156PhosphorylationSRSRTFSSSSEPHQ-
HHCCCCCCCCCCCC-		33.4219429919
1157PhosphorylationRSRTFSSSSEPHQ--
HCCCCCCCCCCCC--		37.2119429919
1158PhosphorylationSRTFSSSSEPHQ---
CCCCCCCCCCCC---		58.0319429919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of E2AK3_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of E2AK3_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of E2AK3_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CCNE_DROMECycEgenetic
20682638
CHK1_DROMEgrpgenetic
20682638
IF2A_DROMEeIF-2alphaphysical
12605680
E2AK3_DROMEPEKphysical
12605680
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of E2AK3_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-624; SER-797; THR-818AND THR-1028, AND MASS SPECTROMETRY.

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