IF2A_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IF2A_DROME
• UniProt AC: P41374
• Protein Name: Eukaryotic translation initiation factor 2 subunit 1
• Gene Name: eIF2alpha {ECO:0000312|FlyBase:FBgn0261609}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 341
• Protein Description: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This preinitiation complex mediates ribosomal recognition of a start codon during the scanning process of the leader region..
• Protein Sequence: MALTSRFYNERYPEIEDVVMVNVLSIAEMGAYVHLLEYNNIEGMILLSELSRRRIRSINKLIRVGKTEPVVVIRVDKEKGYIDLSKRRVSPEDVEKCTERFAKAKAINSLLRHVADILGFEGNEKLEDLYQKTAWHFEKKYNNKTVAYDIFKQSVTDPTVFDECNLEPETKEVLLSNIKRKLVSPTVKIRADIECSCYGYEGIDAVKASLTKGLELSTEELPIRINLIAPPLYVMTTSTTKKTDGLKALEVAIEHIRAKTSEYDGEFKVIMAPKLVTAIDEADLARRLERAEAENAQVAGDDDEEDGADQEGMQFDPEKEFNHKGSGAGRANEEDEEEEED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Phosphorylation	MILLSELSRRRIRSI HHHHHHHHHHHHHHH	21.49	9495316
60	Acetylation	RRIRSINKLIRVGKT HHHHHHHHHHHCCCC	43.55	21791702
184	Phosphorylation	NIKRKLVSPTVKIRA HHHHHHCCCCEEECC	25.86	19429919
186	Phosphorylation	KRKLVSPTVKIRADI HHHHCCCCEEECCEE	27.25	19429919
217	Phosphorylation	LTKGLELSTEELPIR HCCCCCCCCCCCCEE	25.13	25749252
236	Phosphorylation	APPLYVMTTSTTKKT CCCEEEEECCCCCCC	13.93	21082442
237	Phosphorylation	PPLYVMTTSTTKKTD CCEEEEECCCCCCCC	13.14	21082442
238	Phosphorylation	PLYVMTTSTTKKTDG CEEEEECCCCCCCCC	25.55	21082442
240	Phosphorylation	YVMTTSTTKKTDGLK EEEECCCCCCCCCCH	30.25	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
51	S	Phosphorylation	Kinase	EIF2AK	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IF2A_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IF2A_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.