CHK1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHK1_DROME
• UniProt AC: O61661
• Protein Name: Serine/threonine-protein kinase grp
• Gene Name: grp {ECO:0000312|FlyBase:FBgn0261278}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 512
• Subcellular Localization: Nucleus .
• Protein Description: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. May phosphorylate the CDC25 phosphatase stg, which promotes its degradation. This results in increased inhibitory tyrosine phosphorylation of Cdk1-cyclin complexes and consequent inhibition of cell cycle progression..
• Protein Sequence: MAATLTEAGTGPAATREFVEGWTLAQTLGEGAYGEVKLLINRQTGEAVAMKMVDLKKHPDAANSVRKEVCIQKMLQDKHILRFFGKRSQGSVEYIFLEYAAGGELFDRIEPDVGMPQHEAQRYFTQLLSGLNYLHQRGIAHRDLKPENLLLDEHDNVKISDFGMATMFRCKGKERLLDKRCGTLPYVAPEVLQKAYHAQPADLWSCGVILVTMLAGELPWDQPSTNCTEFTNWRDNDHWQLQTPWSKLDTLAISLLRKLLATSPGTRLTLEKTLDHKWCNMQFADNERSYDLVDSAAALEICSPKAKRQRLQSSAHLSNGLDDSISRNYCSQPMPTMRSDDDFNVRLGSGRSKEDGGDRQTLAQEARLSYSFSQPALLDDLLLATQMNQTQNASQNYFQRLVRRMTRFFVTTRWDDTIKRLVGTIERLGGYTCKFGDDGVVTVSTVDRNKLRLVFKAHIIEMDGKILVDCRLSKGCGLEFKRRFIKIKNALEDIVLKGPTTWPIAIATNSVP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
303	Phosphorylation	AAALEICSPKAKRQR HHHHHHCCHHHHHHH	34.79	25749252
313	Phosphorylation	AKRQRLQSSAHLSNG HHHHHHHHHHHHHCC	33.80	19429919
314	Phosphorylation	KRQRLQSSAHLSNGL HHHHHHHHHHHHCCC	13.52	19429919
318	Phosphorylation	LQSSAHLSNGLDDSI HHHHHHHHCCCCHHH	20.98	19429919
339	Phosphorylation	QPMPTMRSDDDFNVR CCCCCCCCCCCCCEE	34.27	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CHK1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHK1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHK1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
Y3427_DROME	CG43427	physical	14605208
RLA1_DROME	RpLP1	physical	14605208
ODR4_DROME	CG10616	physical	15575970
PCNA_DROME	PCNA	physical	15575970
CEG1A_DROME	CenG1A	physical	15575970
RG68F_DROME	RhoGAP68F	physical	15575970
DIMM_DROME	dimm	physical	15575970
ENA_DROME	ena	physical	15575970
MED15_DROME	MED15	physical	15575970
PANG1_DROME	pan	physical	15575970
PANG2_DROME	pan	physical	15575970
LOK_DROME	lok	genetic	22796626
LOK_DROME	lok	genetic	12679037
CHK1_DROME	grp	physical	22853956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.