DIMM_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DIMM_DROME
• UniProt AC: B6VQA1
• Protein Name: Protein dimmed {ECO:0000312|EMBL:AAF53991.1}
• Gene Name: dimm
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 390
• Subcellular Localization: Cytoplasm .
• Protein Description: Transcription factor that regulates neurosecretory (NS) cell function and neuroendocrine cell fate. Acts as a master regulator of common NS functions such as Phm expression and neuropeptide production. Plays a role as a regulator of peptide-containing large dense-core vesicle (LDCV) production and peptidergic cell differentiation. Controls transcription of FMRFamide in Tv neuronal cells and Fur1 in Ap-let cells (Tvb and dorsal apterous cells). Also required for up-regulation of Phm in Tv and Ap-let cells, and expression of three neuropeptide genes, Ms, FMRFamide and Lk. Influences both regulated and constitutive secretory activity in neuroendocrine cells at embryonic and postembryonic level. Loss of function studies show reduced cellular levels of various neuropeptides and neuropeptide biosynthetic enzymes..
• Protein Sequence: MDATQLTELMGSHDFMQLQHQLHHNNNNYNTDGHNGLSSESAEGSSRPVRRATRRTSQLSNNTYDLEMTDSSSQSDDTSGGGGSSNGGGSTTNTGHPSGCSLGGQGPSGRGRVQQASSGACPSTIAPNSTSSNSSNANGNASRRRKGALNAKERNMRRLESNERERMRMHSLNDAFQSLREVIPHVEMERRLSKIETLTLAKNYIINLTHIILSKRNEEAAALELNSGAVGGVLLSNLSSESGGPVASGIPANSNAATICFEDTLASGGAFDCAILAATDGSLLNAATVTTSPAMQSIQSQAIHLQTPMEQQQQQASHLPHHQQAMHGHGHLGASIQSQQQPSLVLNGTTSVGLGIGIGVGVGVGVGVCNNAPSFADINDNFDEPFREFL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	N-linked_Glycosylation	RRTSQLSNNTYDLEM HHHHHHCCCEEEEEE	54.15	-
128	N-linked_Glycosylation	CPSTIAPNSTSSNSS CCCCCCCCCCCCCCC	49.23	-
133	N-linked_Glycosylation	APNSTSSNSSNANGN CCCCCCCCCCCCCCC	49.58	-
140	N-linked_Glycosylation	NSSNANGNASRRRKG CCCCCCCCHHHHHHH	34.25	-
207	N-linked_Glycosylation	LAKNYIINLTHIILS HHHHHHHHHHHHHHC	29.36	-
237	N-linked_Glycosylation	VGGVLLSNLSSESGG HHHHHHHCCCCCCCC	43.86	-
347	N-linked_Glycosylation	QQPSLVLNGTTSVGL CCCEEEECCCCCCCC	37.98	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DIMM_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DIMM_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DIMM_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.