dbPTM

RG68F_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RG68F_DROME
UniProt AC	Q9VTU3
Protein Name	Rho GTPase-activating protein 68F
Gene Name	RhoGAP68F
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	476
Subcellular Localization
Protein Description	Functions as a GTPase-activating protein (GAP) for RhoA/Rho1 during gastrulation by converting it to an inactive GDP-bound state..
Protein Sequence	MDAHSRFAPRLPGPAINPIVDNSDEPQPSLSDLHDFEPKLEFDDTELLAPSPLEKDVMVGDFVLAEDPELEPEEDVNPLEDDFEDQLREQSENFQTPRNKCDFLGTDKQGRHIFGIYASRFPEKSQLEGFVREIIKEIEPFVENDYILVYFHQGLKEDNKPSAQFLWNSYKELDRNFRKNLKTLYVVHPTWFIRVIWNFFSPFISDKFRKKLVYISSLDELRQALGLNKLKLPDNICDLDDKLNPSRKPSTPPPSSNINASRQQQHKMATTHQFGVPLKFIVMNSPCLNSIPPIVRKCVDSLSITGVIDTEGIFRRSGNHSEIMALKERVNRGEDVDLKSVNVHVIAGLLKSFLRDLAEPLLTFELYEDVTGFLDWPKEERSRNVTQLIREKLPEENYELFKYIVEFLVRVMDCEDLNKMTSSNLAIVFGPNFLWSRSTSTSLEEIAPINAFVDFVLQNHKDIYLIDVNQRTVSVD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	NSDEPQPSLSDLHDF CCCCCCCCHHHHHCC	34.95	17372656
31	Phosphorylation	DEPQPSLSDLHDFEP CCCCCCHHHHHCCCC	42.33	22817900
51	Phosphorylation	DTELLAPSPLEKDVM CCCCCCCCCCCCCCE	36.19	19429919
250	Phosphorylation	LNPSRKPSTPPPSSN CCCCCCCCCCCCCCC	57.49	19429919
251	Phosphorylation	NPSRKPSTPPPSSNI CCCCCCCCCCCCCCC	48.63	19429919
255	Phosphorylation	KPSTPPPSSNINASR CCCCCCCCCCCCHHH	41.62	19429919
256	Phosphorylation	PSTPPPSSNINASRQ CCCCCCCCCCCHHHH	47.72	19429919
261	Phosphorylation	PSSNINASRQQQHKM CCCCCCHHHHHHHHH	26.57	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RG68F_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RG68F_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RG68F_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GUS_DROME	gus	physical	15575970
PP4C_DROME	Pp4-19C	physical	15575970
FRY_DROME	fry	physical	15575970
CP6A9_DROME	Cyp6a9	physical	15575970
CEG1A_DROME	CenG1A	physical	15575970

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RG68F_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells."; Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.; Mol. Biosyst. 3:275-286(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29 AND SER-31, AND MASSSPECTROMETRY.	17372656 [Abstract]
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-251, AND MASSSPECTROMETRY.	18327897 [Abstract]