FRY_DROME - dbPTM
FRY_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FRY_DROME
UniProt AC Q9VT28
Protein Name Protein furry
Gene Name fry {ECO:0000312|EMBL:AAF50228.2}
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 3479
Subcellular Localization
Protein Description Trc/fry signaling pathway plays a key role in maintaining the integrity of polarized cell extensions (arista) during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching. Fry positively regulates trc kinase activity..
Protein Sequence MDQLELQDDLFGLEAGVAGTNQNPNEQHLSDPAASPSTSSPANNNATAGAATTSTATVITAVGGAGGGVAAAGVGVVTPTKSPQRNAFQEDAYQANLAGGDSVDNIESAQLDGGNPSGGSPGQRHSINSAEYTSTPKTTRSGPNGSTTASGTTSPINYQLPGDDYPYGIEYESQQLLYQQQQQQQQQQSQQQQQQQQQQQQQLPVGDVEQSSAVTYQSLPVSRQSYASPPALIIPQRQSLLPWGAHSRSSIINVLPSYTQAEMHALAARVASVETSAPRPGEIVMRNLFSDFTAQAEKKIELVMLESADKNLSKLLQRGEDQQFDQLLSALGSVAEHCLPSLLHTLLAWHRRQLSDMEIKNDLKKPAPSGSSSQAATNKPTVDLDFQLQRREAAVEFIFCLALIEILKQLPYHPGHEDLVRSIENLAFKHFKYKDGLQNNPNALNIHMIADLYAEVIGVLAQSRFASVRKRFMSELKELRGKEVSPTTTQSIISLLMGMKFFRVKMVPIEEFEASFQFMHECGQYFLEVKDKDIKHALAGLFVEILVPVAAAVKNEVNVPCVKNFVELLYVQTLDASTKSKHRLALFPLVTCLLCVSQKTFFLTNWHYFLAMCLSNLKNRDAKMSRVALESLFRLLWVYMIRIKCESNSATHSRLQSIVNSLFPKGSKGVVPRDTPLNIFVKIIQFIAQERLDFAMREIVYDLLCVGRSIKLILNPERMSIGLRAFLVVADSLQQKAGEPPMPRTVPVLPSGNTLRVKKTFNKMYVLLTDDTARSIGMSTYFPHVRRVFVDILRALDVHYGRPLMMTNTQNQNKEPDEMLSGERKPRIDLFRTCVAAVPRLIPDTMTPHELVDMLSRLSVHMDEELRILTHQSLTTLVIDFPDWRQDVVHGYTQFLVRDVTDTYPQLLENCTRILFTFLNIWRCATNVNGNNTTSAPSGATNVVNTSQAKMTTATTTTTVVQATVVQVTSAPAKDTASSQLSKQQHLNTASSAASSITTSSGMSSITQHTVLNMASDVGKKNEIPLATTLHFVEGFALVLLCNYRTYLRKLAALILKEVKNLMRALGIPETEPPLIDVMDRCVPGIIEKCLPQLPQTEKTAILNANCIDLQWIAERSSGVWLAGLTDDNSKSSTSTLNLSQSSSTPNASATAASSPQLPFDPWATCLFGLLERQNVLQQCPSAVAQAWPICFTRLNALYSVIDPTPVSDNRASLLRSSAPTKKVPTESQKDSYLRLWRNQVACAMRLVPQIPSVAVRCASPDLSLSSSPDSLNADRSDKSAMGSASPQALYKLVVPLLRCEVVDVRDAAVNALGLINHDALKDLMEELVVYIREAVDCKQENMRRRRRRDALRLQVVRVLEKIAENGTFGVSTCVLERDTMSLHPTFVLYISGAMGYLTSETDKDNLSIREVKAHFCNFIRKMIKNFPLEACATLLSRVLKRNLFNLFAAWCGSFSKPLGYTMQSDHTLEEEKLQFSALQAMSALLCCGQIFNPSYLQDDSIIYKWLDMLLTSKNEKIYQLARDTVVLLLESNPDIGQLLEWVIDRCYTSTPREADACFLALASIFSAKEYPCDHYTSVITVTLLMTGCPRVEVHATALQLLQILDKRFFGSVVGTLHSDSDKEDDKVGTLDVLLSSAYCRSQRFLSKQLAQLRPELTMSIFSEITHRFQSAREDVRALLLQCLLPWLQNMELVATSVPPATPLSYIMYFPDSGTRGRREGTGSTEATEMILNNLFYITAKFSDAHPRDIEELWGTLCQFWPNNLKVILRYLVIMSGMAPTELLPYAKRVALYLVRSCPDRLLDELMAELQTVETLNCLIERTETPPFYRLTSMRKASSHSADGQAAGGINDSRIQDLAVEKGTIHTKRHSGEDPMKIGTCKSDSGIRAYTQAAAAAAAAAVTPGSSGNRPPRGADKIRAASGPSILPRPEDILINDPELRQEENVELRGTSDAAPNGHPHPLPMPEYGGYFAPLTEFLPDVSLPISGFHRCNVAVMLLTDIVVDGIPGIDWTLHLPLMLHILFLGLDHTRIIVREHCKQLCVNLLIVLAEHNDHLTVARILLNSETSKLDLGLTVPALPVIDNNFTELHQQFDSYLLHVSPQAAAYALQHNLSSSTIIAAHHQNLSQTPQSQQQTGSQNGQTTTPPGLTATPAALQINPNNSENSEVPLIHPDEHAPPQPGPSMPIAHVIKSLLKFLAQDTCQPLWNYEDITAKVWAVKSAEQLSCFLKHMVKVFADSYPQARIAERWAQTALQLGLSCSSRHYAGRCLQIFRALNVPINSRMLSDILSRLVETVAEQGEDMQGYVTELLLTLEAAVDSLDSDFRPLDVMKDIFKSTPNLNNKDGGPNSILPGKKSPSGMTPQSSNYSIPSHGRSTSYSVSYCGRKANNSPCDKQVELRNRSSGIDLERSVVCKFGVGGGGAGSALSRSRSAQSLKMLGDTATQDDKMTILAQLFWLSVSLLESDYEHEFMLALRLLTRVLHRLPLDRPDARDKVEKLQQQLKWTAYPGVHALLLKGCTHSATYEPTITLLSQFAPLLTLPVCDPTQSCAFPMNVIALLPYMLLHYEDANEICIRSAENIAQVSTELGAKLENLGTVMTLYSRKTFCKESFQWTKCVVKYLHDTYAHMGLHMVAFLIEVLEKGPQQVQVPVLNVIHCMLHYVDLSAPQAQSINADLLRAIGKYLDTAYWKDSLKILKLIVTRSSSLQVVPPSDGSSAGLSFSFYGAYPDSDMFCKKELAGRTMEFTFDVSQTPLIGRRILLKTEEPVAGGAVSTTGSSSLNSTLTNATTVTVAPSAAQQQTNVQMQQQRANTNVAALAAAAAAQHQQQQHAIGAGSSVVGTPNSPRRSASLSPADTVPLSGWKRPWMSQCRVRECLVNLLTTCGQRVGLPKSPSVIFSQSSDLMERQSSAASSTEETSGPQGDLSSGSRRDDGQPDFTVFKDFDFLEYEDSIAGESTDNFNWGVRRHQLFEGDEDRLNCGSGIGGSIKGGHSSAFEDSFSDKTPILSKRKRQIADDSSDEEAESESPLDEDHRQSFLKSGYSAVPPTSLSLRERRRRNSVSRSDTSGSSAGDLGDLTPCNASPHLPGIIRFSAAIHDEAEENWRRQVQALLVNQPSAHTSELLQQLYRLIKELTFKTVNISKEAKKFFTGIGSQLGNRISLFTDLLSSRADPPQVWCSELQATSPKLFETLRFNVLEVQEHLETFFDRKDQVLECLDAVKTSCKLSLFNEADVAASGLELPSTSSIVYMPFDPASTEVVLDLGRSLYKLMFQLLLLIESNHKISSNVVNHFRMNEDMHDISDLYALVRDALVRYISEAELDCLESSTSTEGEHTPTPSPGLPMTPEEFEAVLTEHIDLQRWPSAIAHVRQYRRISTLNASGYQNVTIFSYNSADNRQKWDEISVILNAYAHGIMKDRTEAFIVSKSDSEVFEIYAILSENLYQVSSALTNMEISMKSYSAGSASGNSHRSEQDIVTNL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
102PhosphorylationANLAGGDSVDNIESA
HHCCCCCCCCCCHHC		34.3530478224
108PhosphorylationDSVDNIESAQLDGGN
CCCCCCHHCCCCCCC		19.9530478224
117PhosphorylationQLDGGNPSGGSPGQR
CCCCCCCCCCCCCCC		60.8430478224
126PhosphorylationGSPGQRHSINSAEYT
CCCCCCCCCCCCEEC		26.1719429919
129PhosphorylationGQRHSINSAEYTSTP
CCCCCCCCCEECCCC		22.3222817900
135PhosphorylationNSAEYTSTPKTTRSG
CCCEECCCCCCCCCC		22.4728490779
225PhosphorylationSLPVSRQSYASPPAL
CCCCCCCCCCCCCEE		22.8921082442
228PhosphorylationVSRQSYASPPALIIP
CCCCCCCCCCEEEEC		24.1521082442
239PhosphorylationLIIPQRQSLLPWGAH
EEECCCCCCCCCCCC		33.7821082442
250PhosphorylationWGAHSRSSIINVLPS
CCCCCHHHHHHHCCC		26.7821082442
751PhosphorylationRTVPVLPSGNTLRVK
CCCCCCCCCCEEEEE		40.2822817900
1213PhosphorylationPVSDNRASLLRSSAP
CCCCCHHHHHHCCCC		25.3821082442
1260PhosphorylationSVAVRCASPDLSLSS
CEEEEECCCCCCCCC		23.6719429919
1838PhosphorylationLTSMRKASSHSADGQ
HHHCCHHCCCCCCCC		31.4522817900
1839PhosphorylationTSMRKASSHSADGQA
HHCCHHCCCCCCCCC		26.7325749252
1841PhosphorylationMRKASSHSADGQAAG
CCHHCCCCCCCCCCC		29.9722817900
1871PhosphorylationTIHTKRHSGEDPMKI
CCCCCCCCCCCCCCC		48.1618511481
1907PhosphorylationAAVTPGSSGNRPPRG
HHCCCCCCCCCCCCC		46.1030478224
1922PhosphorylationADKIRAASGPSILPR
CCCCCCCCCCCCCCC		50.6921082442
2337PhosphorylationVMKDIFKSTPNLNNK
HHHHHHHCCCCCCCC		38.0519429919
2338PhosphorylationMKDIFKSTPNLNNKD
HHHHHHCCCCCCCCC		19.4519429919
2357PhosphorylationSILPGKKSPSGMTPQ
CCCCCCCCCCCCCCC		27.9922817900
2376PhosphorylationSIPSHGRSTSYSVSY
CCCCCCCCCCEEEEE		26.7121082442
2378PhosphorylationPSHGRSTSYSVSYCG
CCCCCCCCEEEEECC		19.3621082442
2391PhosphorylationCGRKANNSPCDKQVE
CCCCCCCCCCHHHHH		27.0622817900
2403PhosphorylationQVELRNRSSGIDLER
HHHHCCCCCCCCCCC		36.1419429919
2404PhosphorylationVELRNRSSGIDLERS
HHHCCCCCCCCCCCE		36.2119429919
2430PhosphorylationAGSALSRSRSAQSLK
HHHHHHHHHCHHHHH		27.4919429919
2432PhosphorylationSALSRSRSAQSLKML
HHHHHHHCHHHHHHH		31.7219429919
2842PhosphorylationAGSSVVGTPNSPRRS
CCCCCCCCCCCCCCC		14.0022817900
2845PhosphorylationSVVGTPNSPRRSASL
CCCCCCCCCCCCCCC		22.4622817900
2849PhosphorylationTPNSPRRSASLSPAD
CCCCCCCCCCCCCCC		24.4019429919
2851PhosphorylationNSPRRSASLSPADTV
CCCCCCCCCCCCCCC		30.5419429919
2853PhosphorylationPRRSASLSPADTVPL
CCCCCCCCCCCCCCC		18.6219429919
2987PhosphorylationCGSGIGGSIKGGHSS
CCCCCCCCCCCCCCC		18.8622817900
2994PhosphorylationSIKGGHSSAFEDSFS
CCCCCCCCCCCCCCC		31.1622817900
2999PhosphorylationHSSAFEDSFSDKTPI
CCCCCCCCCCCCCCC		21.3222817900
3001PhosphorylationSAFEDSFSDKTPILS
CCCCCCCCCCCCCCC		41.9922817900
3004PhosphorylationEDSFSDKTPILSKRK
CCCCCCCCCCCCHHH		22.1322817900
3018PhosphorylationKRQIADDSSDEEAES
HHHHCCCCCCCHHHC		39.9919429919
3019PhosphorylationRQIADDSSDEEAESE
HHHCCCCCCCHHHCC		56.9119429919
3025PhosphorylationSSDEEAESESPLDED
CCCCHHHCCCCCCHH		50.8822817900
3027PhosphorylationDEEAESESPLDEDHR
CCHHHCCCCCCHHHH		39.7922817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FRY_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FRY_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FRY_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of FRY_DROME !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FRY_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129; SER-1838; SER-1841;SER-2357; THR-2842; SER-2845; SER-2851; SER-2853; SER-2999; SER-3001;THR-3004; SER-3018; SER-3019; SER-3025 AND SER-3027, AND MASSSPECTROMETRY.

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