| UniProt ID | PANG1_DROME | |
|---|---|---|
| UniProt AC | P91943 | |
| Protein Name | Protein pangolin, isoforms A/H/I/S | |
| Gene Name | pan | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 751 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Segment polarity protein. Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues. Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.. | |
| Protein Sequence | MPHTHSRHGSSGDDLCSTDEVKIFKDEGDREDEKISSENLLVEEKSSLIDLTESEEKGHKISRPDHSPVFNKLDTHAPSFNMGYLVSPYSYANGSPSGLPVTMANKIGLPPFFCHNADPLSTPPPAHCGIPPYQLDPKMGLTRPALYPFAGGQYPYPMLSSDMSQVASWHTPSVYSASSFRTPYPSSLPINTTLASDFPFRFSPSLLPSVHATSHHVINAHSAIVGVSSKQECGVQDPTTNNRYPRNLEAKHTSNAQSNESKETTNDKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHELSREEQSKYYEKARQERQLHMELYPGWSARDNYGYVSKKKKRKKDRSTTDSGGNNMKKCRARFGLDQQSQWCKPCRRKKKCIRYMEALNGNGPAEDGSCFDEHGSQLSDDDEDDYDDDKLGGSCGSADETNKIEDEDSESLNQSMPSPGCLSGLSSLQSPSTTMSLASPLNMNANSATNVIFPASSNALLIVGADQPTAQQRPTLVSTSGSSSGSTSSISTTPNTSSTVSPVTCMTGPCLGSSQERAMMLGNRFSHLGMGLSPPVVSTSTSKSEPFFKPHPTVCNNPIFALPSIGNCSLNISSMPNTSRNPIGANPRDINNPLSINQLTKRREYKNVELIEASESKTIVAHAATSIIQHVAVNGYHANHSLLNSNLGHLHHQLNNRTENPNRSEQTMLSVSNHSVNSSECHKESDSQAIVSSNPPNAGSSDNGVISVS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Phosphorylation | HTHSRHGSSGDDLCS CCCCCCCCCCCCCCC | 25.64 | 25749252 | |
| 10 (in isoform 4) | Phosphorylation | - | 25.64 | 25749252 | |
| 10 (in isoform 5) | Phosphorylation | - | 25.64 | 25749252 | |
| 10 (in isoform 6) | Phosphorylation | - | 25.64 | 25749252 | |
| 11 | Phosphorylation | THSRHGSSGDDLCST CCCCCCCCCCCCCCC | 51.32 | 25749252 | |
| 11 (in isoform 4) | Phosphorylation | - | 51.32 | 25749252 | |
| 11 (in isoform 5) | Phosphorylation | - | 51.32 | 25749252 | |
| 11 (in isoform 6) | Phosphorylation | - | 51.32 | 25749252 | |
| 25 | Acetylation | TDEVKIFKDEGDRED CCEEEEECCCCCCCC | 59.34 | 9774110 | |
| 67 | Phosphorylation | KISRPDHSPVFNKLD CCCCCCCCCCCCCCC | 30.09 | 19429919 | |
| 67 (in isoform 4) | Phosphorylation | - | 30.09 | 19429919 | |
| 67 (in isoform 5) | Phosphorylation | - | 30.09 | 19429919 | |
| 67 (in isoform 6) | Phosphorylation | - | 30.09 | 19429919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PANG1_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PANG1_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PANG1_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ARM_DROME | arm | physical | 17113388 | |
| EWG_DROME | ewg | genetic | 22028028 | |
| RBF_DROME | Rbf | genetic | 15001704 | |
| ARM_DROME | arm | genetic | 11128568 | |
| ARM_DROME | arm | genetic | 21399610 | |
| OVO_DROME | ovo | genetic | 10421370 | |
| GROU_DROME | gro | genetic | 9783586 | |
| GROU_DROME | gro | genetic | 11128568 | |
| 2ABA_DROME | tws | genetic | 14973271 | |
| ARM_DROME | arm | physical | 10075848 | |
| ARM_DROME | arm | physical | 11955446 | |
| ARM_DROME | arm | physical | 9039917 | |
| ARM_DROME | arm | physical | 9751710 | |
| ARM_DROME | arm | physical | 16169192 | |
| MAD_DROME | Mad | physical | 21990430 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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