OVO_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OVO_DROME
• UniProt AC: P51521
• Protein Name: Transcriptional regulator ovo {ECO:0000303|PubMed:7935398}
• Gene Name: ovo {ECO:0000303|PubMed:7935398, ECO:0000312|FlyBase:FBgn0003028}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1351
• Subcellular Localization: Cytoplasm . Nucleus .; Transcriptional activator shavenbaby: Nucleus, nucleoplasm . Diffuse nucleoplasmic distribution.; Isoform B: Nucleus . Localizes to the nuclear foci.; Isoform C: Nucleus . Localizes to the nuclear foci.; Isoform D: Cy
• Protein Description: Transcriptional regulator with essential functions in the germline and soma. [PubMed: 9012532]
• Protein Sequence: MPKIFLIKNRLHQQQQRLLESQNLLQHKNQDDERLVPPLSPSGSGSGPSPTPTSQPPPEPQGQGQQVLGQVPDSDQQPLSLTRKRFHHRRHYFGQSRHSLDHLNQNQSPNPNANANPNQIQNPAELEVECATGQVQNENFAAELLQRLTPNTATTAQNNIVNNLVNNSRAATSVLATKDCTIENSPISIPKNQRAEDEEEQEDQEKEKPAEREREKSDERTEQVEKEERVEREEEEDDEVDVGVEAPRPRFYNTGVVLTQAQRKEYPQEPKDLSLTIAKSSPASPHIHSDSESDSDSDGGCKLIVDEKPPLPVIKPLSLRLRSTPPPADQRPSPPPPRDPAPAVRCSVIQRAPQSQLPTSRAGFLLPPLDQLGPEQQEPIDYHVPKRRSPSYDSDEELNARRLERARQVREARRRSTILAARVLLAQSQRLNPRLVRSLPGILAAAAGHGRNSSSSSGAAGQGFQSSGFGSQNSGSGSSSGNQNAGSGAGSPGSGAGGGGGMGGGRDGRGNYGPNSPPTGALPPFYESLKSGQQSTASNNTGQSPGANHSHFNANPANFLQNAAAAAYIMSAGSGGGGCTGNGGGGASGPGGGPSANSGGGGGGGGGNGYINCGGVGGPNNSLDGNNLLNFASVSNYNESNSKFHNHHHHHQHNNNNNNNGGQTSMMGHPFYGGNPSAYGIILKDEPDIEYDEAKIDIGTFAQNIIQATMGSSGQFNASAYEDAIMSDLASSGQCPNGAVDPLQFTATLMLSSQTDHLLEQLSDAVDLSSFLQRSCVDDEESTSPRQDFELVSTPSLTPDSVTPVEQHNTNTTQLDVLHENLLTQLTHNIVRGGSNQQQQHHQQHGVQQQQQQQHSVQQQQQHNVQQQHGVQQQHVQQQPPPSYQHATRGLMMQQQPQHGGYQQQAAIMSQQQQQLLSQQQQQSHHQQQQQQQHAAAYQQHNIYAQQQQQQQQQHHQQQQQQQHHHFHHQQQQQPQPQSHHSHHHGHGHDNSNMSLPSPTAAAAAAAAAAAAAAAAAAHLQRPMSSSSSSGGTNSSNSSGGSSNSPLLDANAAAAAAAALLDTKPLIQSLGLPPDLQLEFVNGGHGIKNPLAVENAHGGHHRIRNIDCIDDLSKHGHHSQHQQQQGSPQQQNMQQSVQQQSVQQQQSLQQQQQQQHHQHHSNSSASSNASSHGSAEALCMGSSGGANEDSSSGNNKFVCRVCMKTFSLQRLLNRHMKCHSDIKRYLCTFCGKGFNDTFDLKRHTRTHTGVRPYKCNLCEKSFTQRCSLESHCQKVHSVQHQYAYKERRAKMYVCEECGHTTCEPEVHYLHLKNNHPFSPALLKFYDKRHFKFTNSQFANNLLGQLPMPVHN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Ubiquitination	-----MPKIFLIKNR -----CCEEEEECHH	58.93	PubMed
8	Ubiquitination	MPKIFLIKNRLHQQQ CCEEEEECHHHHHHH	37.86	PubMed
28	Ubiquitination	SQNLLQHKNQDDERL HHHHHHCCCCCCCCC	43.26	PubMed

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OVO_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OVO_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OVO_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAGP1_DROME	RanGAP	physical	14605208
SNRPA_DROME	snf	genetic	7713427
OTU_DROME	otu	genetic	10525184
MLE_DROME	mle	genetic	8187645
MLE_DROME	mle	genetic	9883585
SXL_DROME	Sxl	genetic	9883585
MYSA_DROME	Mhc	physical	25242320
G6PI_DROME	Pgi	physical	25242320
ADH_DROME	Adh	physical	25242320
GOSR2_DROME	Membrin	physical	25242320
ZFPL1_DROME	CG5382	physical	25242320
K10_DROME	fs(1)K10	physical	25242320

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.