ADH_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADH_DROME
• UniProt AC: P00334
• Protein Name: Alcohol dehydrogenase
• Gene Name: Adh
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 256
• Protein Sequence: MSFTLTNKNVIFVAGLGGIGLDTSKELLKRDLKNLVILDRIENPAAIAELKAINPKVTVTFYPYDVTVPIAETTKLLKTIFAQLKTVDVLINGAGILDDHQIERTIAVNYTGLVNTTTAILDFWDKRKGGPGGIICNIGSVTGFNAIYQVPVYSGTKAAVVNFTSSLAKLAPITGVTAYTVNPGITRTTLVHKFNSWLDVEPQVAEKLLAHPTQPSLACAENFVKAIELNQNGAIWKLDLGTLEAIQWTKHWDSGI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSFTLTNKN ------CCEECCCCC	27.26	6821373
56	Ubiquitination	ELKAINPKVTVTFYP HHHCCCCCEEEEEEC	46.15	31113955
166	Phosphorylation	AVVNFTSSLAKLAPI EEEEECHHHHHHCCC	29.32	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADH_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADH_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADH_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KARG_DROME	Argk	physical	22036573
GPDA_DROME	Gpdh	physical	22036573
ALF_DROME	Ald	physical	22036573
MYSA_DROME	Mhc	physical	22036573
MLC1_DROME	Mlc1	physical	22036573
MYSP1_DROME	Prm	physical	22036573
MYSP2_DROME	Prm	physical	22036573
TPM2_DROME	Tm2	physical	22036573
MLR_DROME	Mlc2	physical	22036573
TNNT_DROME	up	physical	22036573
APLP_DROME	Rfabg	physical	22036573
LSP2_DROME	Lsp2	physical	22036573
VIT3_DROME	Yp3	physical	22036573
ACTN_DROME	Actn	physical	22036573
GSTS1_DROME	GstS1	physical	22036573
ENO_DROME	Eno	physical	22036573
TNNI_DROME	wupA	physical	22036573
G3P2_DROME	Gapdh2	physical	22036573
TNNC1_DROME	TpnC41C	physical	22036573
OB56D_DROME	Obp56d	physical	22036573
FTN_DROME	fln	physical	22036573
PYG_DROME	GlyP	physical	22036573
NPLP2_DROME	Nplp2	physical	22036573
VIT2_DROME	Yp2	physical	22036573
VIT1_DROME	Yp1	physical	22036573
DHE3_DROME	Gdh	physical	22036573
PGK_DROME	Pgk	physical	22036573
CYC2_DROME	Cyt-c-p	physical	22036573
CISY_DROME	kdn	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"The complete amino acid sequence of three alcohol dehydrogenasealleloenzymes (AdhN-11, AdhS and AdhUF) from the fruitfly Drosophilamelanogaster.";
Thatcher D.R.;
Biochem. J. 187:875-883(1980).
Cited for: PROTEIN SEQUENCE OF 2-256 (ALLELES ADH-F; ADH-S; ADH-UF AND ADH-N11),AND ACETYLATION AT SER-2.
PubMed: 6821373