MYSP2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYSP2_DROME
• UniProt AC: P35416
• Protein Name: Paramyosin, short form
• Gene Name: Prm
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 640
• Subcellular Localization: Cytoplasm, myofibril. Thick filaments of the myofibrils.
• Protein Description: Paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles..
• Protein Sequence: MALALKQRPSRFRPTTTTYEDNYGYTMNFYQPMLDYLDAKAKGLEVKKPHLPWVSERGLKQYRPSNAVRQYNADEIVRLSRTCAARADEILLNFRAQKRSPFSVQKLVDASRVTKHLEPDTVVERSRQRRRRRQEELEDLIKRDTLKILQRIRKIELDNELDKMSDDFKRSIRGKSASAIAQALLSESEKNIKTAKKEEEDYIAQTLVRSSRAVSRARSRSSSPLDGQYRAHALHIELMDDRLVDKLDHRVSSSLHNVKRQLSTLNQRTVEFYADSSKQTSIEIEQLNARVIEAETRLKTEVTRIKKKLQIQITELEMSLDVANKTNIDLQKVIKKQSLQLTELQAHYEDVQRQLQATLDQYAVAQRRLAGLNGELEEVRSHLDSANRAKRTVELQYEEAASRINELTTANVSLVSIKSKLEQELSVVASDYEEVSKELRISDERYQKVQVELKHVVEQVHEEQERIVKLETIKKSLEVEVKNLSIRLEEVELNAVAGSKRIISKLEARIRDLELELEEEKRRHAETIKILRKKERTVKEVLVQCEEDQKNLILLQDALDKSTAKINIYRRQLSEQEGVSQQTTTRVRRFQRELEAAEDRADTAESSLNIIRAKHRTFVTTSTVPGSQVYIQETTRTITE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
100	Phosphorylation	NFRAQKRSPFSVQKL HHHCCCCCCCCHHHH	37.01	27794539
165	Phosphorylation	DNELDKMSDDFKRSI CCHHHHCCHHHHHHH	39.51	27794539
176	Phosphorylation	KRSIRGKSASAIAQA HHHHHCHHHHHHHHH	30.22	28490779
178	Phosphorylation	SIRGKSASAIAQALL HHHCHHHHHHHHHHH	27.57	28490779
186	Phosphorylation	AIAQALLSESEKNIK HHHHHHHCHHHHHHH	39.67	27794539
188	Phosphorylation	AQALLSESEKNIKTA HHHHHCHHHHHHHHC	50.96	27794539
219	Phosphorylation	RAVSRARSRSSSPLD HHHHHHHHCCCCCCC	35.21	28490779
221	Phosphorylation	VSRARSRSSSPLDGQ HHHHHHCCCCCCCHH	36.09	28490779
222	Phosphorylation	SRARSRSSSPLDGQY HHHHHCCCCCCCHHH	34.56	28490779
223	Phosphorylation	RARSRSSSPLDGQYR HHHHCCCCCCCHHHH	30.63	28490779
229	Phosphorylation	SSPLDGQYRAHALHI CCCCCHHHHHEEEEE	18.46	28490779
252	Phosphorylation	DKLDHRVSSSLHNVK HHHCHHHHHHHHHHH	17.73	27794539
253	Phosphorylation	KLDHRVSSSLHNVKR HHCHHHHHHHHHHHH	33.78	27794539
254	Phosphorylation	LDHRVSSSLHNVKRQ HCHHHHHHHHHHHHH	26.58	27794539
263	Phosphorylation	HNVKRQLSTLNQRTV HHHHHHHHHCCHHEE	23.62	27794539
264	Phosphorylation	NVKRQLSTLNQRTVE HHHHHHHHCCHHEEE	38.02	27794539
269	Phosphorylation	LSTLNQRTVEFYADS HHHCCHHEEEEECCC	18.02	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYSP2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYSP2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYSP2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RU17_DROME	snRNP-U1-70K	physical	14605208
MYSA_DROME	Mhc	physical	22036573
TPM2_DROME	Tm2	physical	22036573
TNNT_DROME	up	physical	22036573
TNNI_DROME	wupA	physical	22036573
TNNC1_DROME	TpnC41C	physical	22036573
ATC1_DROME	Ca-P60A	physical	22036573
ATP5J_DROME	ATPsyn-Cf6	physical	22036573
OB56D_DROME	Obp56d	physical	22036573
ICLN_DROME	icln	physical	22036573
IDH3A_DROME	l(1)G0156	physical	22036573
NPLP2_DROME	Nplp2	physical	22036573
OVO_DROME	ovo	physical	25242320
CISY_DROME	kdn	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.