TPM2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPM2_DROME
• UniProt AC: P09491
• Protein Name: Tropomyosin-2
• Gene Name: Tm2
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 284
• Protein Description: Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. May also regulate motor systems required to maintain nuclear integrity and apico-basal polarity during embryogenesis..
• Protein Sequence: MDAIKKKMQAMKLEKDNAIDKADTCENQAKDANSRADKLNEEVRDLEKKFVQVEIDLVTAKEQLEKANTELEEKEKLLTATESEVATQNRKVQQIEEDLEKSEERSTTAQQKLLEATQSADENNRMCKVLENRSQQDEERMDQLTNQLKEARMLAEDADTKSDEVSRKLAFVEDELEVAEDRVRSGESKIMELEEELKVVGNSLKSLEVSEEKANQRVEEFKREMKTLSIKLKEAEQRAEHAEKQVKRLQKEVDRLEDRLFNEKEKYKAICDDLDQTFAELTGY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
83	Phosphorylation	KLLTATESEVATQNR HHHHHHHHHHHHHHH	32.77	27794539
206	Phosphorylation	VVGNSLKSLEVSEEK HHHHHHHHCCCCHHH	34.75	27794539
269 (in isoform 2)	Phosphorylation	-	12.45	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPM2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPM2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPM2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TFP11_DROME	sip1	physical	14605208
SRC64_DROME	Src64B	physical	14605208
PP2B2_DROME	Pp2B-14D	physical	14605208
MYSA_DROME	Mhc	physical	22036573
TNNT_DROME	up	physical	22036573
GSTS1_DROME	GstS1	physical	22036573
FTN_DROME	fln	physical	22036573
TNNC1_DROME	TpnC41C	physical	22036573
IDH3A_DROME	l(1)G0156	physical	22036573
AT5F1_DROME	ATPsyn-b	physical	22036573
ATP5J_DROME	ATPsyn-Cf6	physical	22036573
ATC1_DROME	Ca-P60A	physical	22036573
VDAC_DROME	porin	physical	22036573
ATPK_DROME	CG4692	physical	22036573
NPLP2_DROME	Nplp2	physical	22036573
ATPO_DROME	Oscp	physical	22036573
ICLN_DROME	icln	physical	22036573
OB56D_DROME	Obp56d	physical	22036573
CISY_DROME	kdn	physical	22036573
TPM2_DROME	Tm2	physical	16752200

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.