ATPK_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATPK_DROME
• UniProt AC: Q9W141
• Protein Name: Putative ATP synthase subunit f, mitochondrial
• Gene Name: CG4692
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 107
• Subcellular Localization: Mitochondrion membrane.
• Protein Description: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity)..
• Protein Sequence: MAFGDYPAEYNPKVHGPYDPARFYGKADVPFGQVKLGEIGAWLGRRNKTPNAVAGAVSRAWWRWQHKYVFPKRAGIAPFFQLTVASMTFFYLINYTKLKHHRNYKYH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Acetylation	YPAEYNPKVHGPYDP CCCCCCCCCCCCCCH	43.13	21791702
26	Acetylation	DPARFYGKADVPFGQ CHHHHCCCCCCCCCE	29.99	21791702
49	Phosphorylation	WLGRRNKTPNAVAGA HHCCCCCCCCHHHHH	25.89	22668510
67	Ubiquitination	AWWRWQHKYVFPKRA HHHHHHCCCCCCCCC	28.19	31113955

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATPK_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATPK_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATPK_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KRI1_DROME	CG5645	physical	14605208
MYSA_DROME	Mhc	physical	22036573
ATPB_DROME	ATPsyn-beta	physical	25023514

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.