MYSA_DROME - dbPTM
MYSA_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MYSA_DROME
UniProt AC P05661
Protein Name Myosin heavy chain, muscle
Gene Name Mhc
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1962
Subcellular Localization Cytoplasm, myofibril. Thick filaments of the myofibrils.
Protein Description Muscle contraction..
Protein Sequence MPKPVANQEDEDPTPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHIMFVMEQEEYKKEGINWDFIDFGMDLLACIDLIEKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYQILNPRGIKDLDCPKKASKVLIESTELNEDLYRLGHTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEHDRQTCHNELNQTRTACDQLGRDKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGRAGSVGRGASPAPRATSVRPQFDGLAFPPRFDLAPENEF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
202PhosphorylationYFATVGASKKTDEAA
EEEECCCCCCHHHHH		28.8527794539
211PhosphorylationKTDEAAKSKGSLEDQ
CHHHHHHCCCCHHHH		37.2127794539
214PhosphorylationEAAKSKGSLEDQVVQ
HHHHCCCCHHHHHHH		32.1127794539
245AcetylationDNSSRFGKFIRIHFG
CCCCCCCEEEEEEEC		34.6021791702
628PhosphorylationFADHAGQSGGGEQAK
HHCCCCCCCCCCCCC		38.1927794539
889PhosphorylationEKTALLDSLSGEKGA
HHHHHHHHHCCCCCH		25.1427794539
891PhosphorylationTALLDSLSGEKGALQ
HHHHHHHCCCCCHHH		49.1927794539
900PhosphorylationEKGALQDYQERNAKL
CCCHHHHHHHHHHHH		10.1827794539
1087PhosphorylationQRKDKELSSITAKLE
HHHHHHHHHHEEECC		22.3027794539
1260PhosphorylationHTLNEVQSKLDETNR
HHHHHHHHHHHHHCC		40.1227794539
1275PhosphorylationTLNDFDASKKKLSIE
CHHHCHHHHCCCCCC		47.0227794539
1280PhosphorylationDASKKKLSIENSDLL
HHHHCCCCCCCHHHH		36.4128490779
1295PhosphorylationRQLEEAESQVSQLSK
HHHHHHHHHHHHHHH		42.8227794539
1306PhosphorylationQLSKIKISLTTQLED
HHHHCEEEEEECHHH		18.0527794539
1361PhosphorylationADLQRQLSKANAEAQ
HHHHHHHHHHHHHHH		22.7627794539
1372PhosphorylationAEAQVWRSKYESDGV
HHHHHHHHHHHCCCC		24.7127794539
1421PhosphorylationEKTKQRLSTEVEDLQ
HHHHHHHHHHHHHHH		25.3927794539
1422PhosphorylationKTKQRLSTEVEDLQL
HHHHHHHHHHHHHHH		48.9527794539
1565PhosphorylationLRAQLELSQVRQEID
HHHHHHHHHHHHHHH		19.7728490779
1595PhosphorylationNHQRALDSMQASLEA
HHHHHHHHHHHHHHH		17.4027794539
1738PhosphorylationSELQTLHSDLDELLN
HHHHHHHHHHHHHHH		42.8727794539
1850PhosphorylationERRVKELSFQSEEDR
HHHHHHHHCCCHHHH		23.4927794539
1917PhosphorylationDLAEQAISKFRAKGR
HHHHHHHHHHHHCCC		28.8527794539
1939PhosphorylationASPAPRATSVRPQFD
CCCCCCCCCCCCCCC		29.0928490779
1940PhosphorylationSPAPRATSVRPQFDG
CCCCCCCCCCCCCCC		18.3628490779
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MYSA_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MYSA_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MYSA_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VINC_DROMEVincgenetic
26084806
SCNA_DROMEparagenetic
15051736
TPM2_DROMETm2genetic
15051736
ACT6_DROMEAct88Fgenetic
11134077
CANB2_DROMECanB2genetic
16297904
CISY_DROMEkdnphysical
22036573
MYSA_DROMEMhcphysical
22370558
LASP1_DROMELaspphysical
25113030
FTN_DROMEflnphysical
12663941
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MYSA_DROME

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Related Literatures of Post-Translational Modification

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