| UniProt ID | SCNA_DROME | |
|---|---|---|
| UniProt AC | P35500 | |
| Protein Name | Sodium channel protein para | |
| Gene Name | para | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 2131 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . |
|
| Protein Description | Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.. | |
| Protein Sequence | MTEDSDSISEEERSLFRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLEQGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTEVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARKGNPIEETGEIGEIAARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKARGEGGGSFEPDTDHGDGGDPDAGDPAPDEATDGDAPAGGDGSVNGTAEGAADADESNVNSPGEDAAAAAAAAAAAAAAGTTTAGSPGAGSAGRQTAVLVESDGFVTKNGHKVVIHSRSPSITSRTADV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 313 | N-linked_Glycosylation | PLDGSWGNLTDENWD CCCCCCCCCCCCCCC | 33.24 | - | |
| 325 | N-linked_Glycosylation | NWDYHNRNSSNWYSE CCCCCCCCCCCCCCC | 55.92 | - | |
| 343 | N-linked_Glycosylation | ISFPLCGNISGAGQC CCCCCCCCCCCCCCC | 25.02 | - | |
| 553 | Phosphorylation | ATKVRKVSTTSLSLP CCEEEEEEECCCCCC | 29.06 | - | |
| 570 | Phosphorylation | PFNIRRGSRSSHKYT CCCCCCCCCCCCCEE | 27.46 | - | |
| 982 | N-linked_Glycosylation | DGDLPRWNFTDFMHS CCCCCCCCCCHHHHH | 31.08 | - | |
| 1191 | Phosphorylation | DDTASINSYGSHKNR CCCCCCCCCCCCCCC | 29.24 | 27794539 | |
| 1194 | Phosphorylation | ASINSYGSHKNRPFK CCCCCCCCCCCCCCC | 24.05 | 27794539 | |
| 1463 | N-linked_Glycosylation | YFKCEDMNGTKLSHE CEEEECCCCCCCCEE | 68.27 | - | |
| 1482 | N-linked_Glycosylation | RNACESENYTWVNSA CCCCCCCCCCCCCCC | 49.14 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 553 | S | Phosphorylation | Kinase | PKA | - | Uniprot |
| 570 | S | Phosphorylation | Kinase | PKA | - | Uniprot |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SCNA_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SCNA_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CAC1A_DROME | cac | genetic | 26771829 | |
| SHAKB_DROME | shakB | genetic | 11535671 | |
| INE_DROME | ine | genetic | 11880499 | |
| ESCA_DROME | esg | genetic | 15654097 | |
| SNAI_DROME | sna | genetic | 15654097 | |
| MLE_DROME | mle | genetic | 11535671 | |
| CHN_DROME | chn | genetic | 23797108 | |
| KINH_DROME | Khc | genetic | 8770597 | |
| TIPE_DROME | tipE | genetic | 21115970 | |
| LAMA_DROME | LanA | genetic | 23054837 | |
| MDR65_DROME | Mdr65 | genetic | 23941042 | |
| KCC2A_DROME | CaMKII | genetic | 12115891 | |
| DYN_DROME | shi | genetic | 26341658 | |
| ATNA_DROME | Atpalpha | genetic | 16272407 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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