| UniProt ID | KCC2A_DROME | |
|---|---|---|
| UniProt AC | Q00168 | |
| Protein Name | Calcium/calmodulin-dependent protein kinase type II alpha chain | |
| Gene Name | CaMKII | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 530 | |
| Subcellular Localization | ||
| Protein Description | A key regulator of plasticity in synaptic physiology and behavior, alterations in its activity produce pleiotrophic effects that involve synaptic transmission and development as well as various aspects of behavior. Directly modulates eag potassium channels.. | |
| Protein Sequence | MAAPAACTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSMITKKGEGSQVKESTDSSSTTLEDDDIKEDKKGTVDRSTTVVSKEPEDIRILCPAKTYQQNIGNSQCSSARRQEIIKITEQLIEAINSGDFDGYTKICDPHLTAFEPEALGNLVEGIDFHKFYFENVLGKNCKAINTTILNPHVHLLGEEAACIAYVRLTQYIDKQGHAHTHQSEETRVWHKRDNKWQNVHFHRSASAKISGATTFDFIPQK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 280 | Phosphorylation | CQRERVASVVHRQET HCHHHHHHHHCHHHH | 23.09 | 19429919 | |
| 287 | Phosphorylation | SVVHRQETVDCLKKF HHHCHHHHHHHHHHH | 17.20 | 16880127 | |
| 306 | Phosphorylation | KLKGAILTTMLATRN HHHHHHHHHHHHHCC | 12.21 | 14687552 | |
| 307 | Phosphorylation | LKGAILTTMLATRNF HHHHHHHHHHHHCCC | 13.52 | 14687552 | |
| 311 | Phosphorylation | ILTTMLATRNFSSRS HHHHHHHHCCCCCCC | 23.37 | 21082442 | |
| 315 | Phosphorylation | MLATRNFSSRSMITK HHHHCCCCCCCCEEE | 28.52 | 30478224 | |
| 316 | Phosphorylation | LATRNFSSRSMITKK HHHCCCCCCCCEEEC | 25.00 | 30478224 | |
| 318 | Phosphorylation | TRNFSSRSMITKKGE HCCCCCCCCEEECCC | 19.24 | 27794539 | |
| 327 | Phosphorylation | ITKKGEGSQVKESTD EEECCCCCCCEECCC | 27.74 | 1910789 | |
| 332 | Phosphorylation | EGSQVKESTDSSSTT CCCCCEECCCCCCCC | 31.62 | 19429919 | |
| 333 | Phosphorylation | GSQVKESTDSSSTTL CCCCEECCCCCCCCC | 40.78 | 19429919 | |
| 335 | Phosphorylation | QVKESTDSSSTTLED CCEECCCCCCCCCCC | 26.69 | 27794539 | |
| 336 | Phosphorylation | VKESTDSSSTTLEDD CEECCCCCCCCCCCC | 34.22 | 19429919 | |
| 337 | Phosphorylation | KESTDSSSTTLEDDD EECCCCCCCCCCCCC | 29.39 | 19429919 | |
| 338 | Phosphorylation | ESTDSSSTTLEDDDI ECCCCCCCCCCCCCC | 37.03 | 19429919 | |
| 339 | Phosphorylation | STDSSSTTLEDDDIK CCCCCCCCCCCCCCC | 30.05 | 19429919 | |
| 352 | Phosphorylation | IKEDKKGTVDRSTTV CCCCCCCCCCCCEEE | 28.28 | 27794539 | |
| 352 (in isoform 2) | Phosphorylation | - | 28.28 | 27794539 | |
| 352 (in isoform 3) | Phosphorylation | - | 28.28 | 27794539 | |
| 358 | Phosphorylation | GTVDRSTTVVSKEPE CCCCCCEEEECCCHH | 21.84 | 21082442 | |
| 358 (in isoform 2) | Phosphorylation | - | 21.84 | 27794539 | |
| 358 (in isoform 3) | Phosphorylation | - | 21.84 | 27794539 | |
| 383 | Phosphorylation | YQQNIGNSQCSSARR CHHHCCCCCCCHHHH | 27.61 | 27794539 | |
| 523 | Phosphorylation | AKISGATTFDFIPQK CEECCCEEECCCCCC | 22.22 | 21082442 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 287 | T | Phosphorylation | Kinase | KCC2A | Q00168 | PhosphoELM |
| 287 | T | Phosphorylation | Kinase | CAMK2-FAMILY | - | GPS |
| 306 | T | Phosphorylation | Kinase | KCC2A | Q00168 | PhosphoELM |
| 306 | T | Phosphorylation | Kinase | CAMK2-FAMILY | - | GPS |
| 307 | T | Phosphorylation | Kinase | KCC2A | Q00168 | PhosphoELM |
| 307 | T | Phosphorylation | Kinase | CAMK2-FAMILY | - | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KCC2A_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KCC2A_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CCDCX_DROME | CG32809 | physical | 14605208 | |
| CSKP_DROME | CASK | genetic | 23543616 | |
| CSKP_DROME | CASK | genetic | 24062638 | |
| DLG1_DROME | dlg1 | physical | 10458610 | |
| CALM_DROME | Cam | physical | 8702694 | |
| CSKP_DROME | CASK | physical | 14687552 | |
| KCC2A_DROME | CaMKII | physical | 10458610 | |
| KCC2A_DROME | CaMKII | physical | 8769895 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-327, AND MASSSPECTROMETRY. | |
| "Activity-dependent gating of CaMKII autonomous activity by DrosophilaCASK."; Hodge J.J., Mullasseril P., Griffith L.C.; Neuron 51:327-337(2006). Cited for: AUTOPHOSPHORYLATION AT THR-287, AND ENZYME REGULATION. | |
| "Regulation of the Ca2+/CaM-responsive pool of CaMKII by scaffold-dependent autophosphorylation."; Lu C.S., Hodge J.J., Mehren J., Sun X.X., Griffith L.C.; Neuron 40:1185-1197(2003). Cited for: FUNCTION, INTERACTION WITH CASK, AUTOPHOSPHORYLATION AT THR-287;THR-306 AND THR-307, AND MUTAGENESIS OF THR-306 AND THR-307. | |
