DYN_DROME - dbPTM
DYN_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DYN_DROME
UniProt AC P27619
Protein Name Dynamin
Gene Name shi
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 877
Subcellular Localization Cytoplasm. Cytoplasm, cytoskeleton. Microtubule-associated.
Protein Description Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting..
Protein Sequence MDSLITIVNKLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLILQLINGVTEYGEFLHIKGKKFSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVLNLTLIDLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRTIGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIEGRKDIHQALAAERKFFLSHPSYRHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEFKHFQPGDASIKTKAMLQMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIVKMACDEKELRREISFAIRNIHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQELSVVVRMCTAKMSRYPRLREETERIITTHVRQREHSCKEQILLLIDFELAYMNTNHEDFIGFANAQNKSENANKTGTRQLGNQVIRKGHMVIQNLGIMKGGSRPYWFVLTSESISWYKDEDEKEKKFMLPLDGLKLRDIEQGFMSMSRRVTFALFSPDGRNVYKDYKQLELSCETVEDVESWKASFLRAGVYPEKQETQENGDESASEESSSDPQLERQVETIRNLVDSYMKIVTKTTRDMVPKAIMMLIINNAKDFINGELLAHLYASGDQAQMMEESAESATRREEMLRMYRACKDALQIIGDVSMATVSSPLPPPVKNDWLPSGLDNPRLSPPSPGGVRGKPGPPAQSSLGGRNPPLPPSTGRPAPAIPNRPGGGAPPLPGGRPGGSLPPPMLPSRVSGAVGGAIVQQSGANRYVPESMRGQVNQAVGQAAINELSNAFSSRFK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
594AcetylationPDGRNVYKDYKQLEL
CCCCCHHHCHHHEEE		50.7521791702
628PhosphorylationVYPEKQETQENGDES
CCCCCHHCCCCCCCC		38.3929892262
635PhosphorylationTQENGDESASEESSS
CCCCCCCCCCCCCCC		41.6619429919
637PhosphorylationENGDESASEESSSDP
CCCCCCCCCCCCCCH		51.6919429919
742PhosphorylationDVSMATVSSPLPPPV
CCEECCCCCCCCCCC		23.1427794539
743PhosphorylationVSMATVSSPLPPPVK
CEECCCCCCCCCCCC		26.5627794539
756PhosphorylationVKNDWLPSGLDNPRL
CCCCCCCCCCCCCCC		50.2222817900
764PhosphorylationGLDNPRLSPPSPGGV
CCCCCCCCCCCCCCC		35.7221082442
767PhosphorylationNPRLSPPSPGGVRGK
CCCCCCCCCCCCCCC		39.2921082442
782PhosphorylationPGPPAQSSLGGRNPP
CCCCCHHCCCCCCCC		20.9621082442
820PhosphorylationPGGRPGGSLPPPMLP
CCCCCCCCCCCCCCC		43.5521082442
831PhosphorylationPMLPSRVSGAVGGAI
CCCCCCCCCCCCCEE		21.6621082442
847PhosphorylationQQSGANRYVPESMRG
ECCCCCCCCCHHHHH		21.8422668510
873PhosphorylationNELSNAFSSRFK---
HHHHHHHHHHCC---		20.4222668510
874PhosphorylationELSNAFSSRFK----
HHHHHHHHHCC----		34.9722668510
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DYN_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DYN_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DYN_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DYL1_DROMEctpgenetic
15829565
PPT1_DROMEPpt1genetic
24091420
ADT_DROMEsesBgenetic
14668379
CLH_DROMEChcgenetic
18762582
WNTG_DROMEwggenetic
10477304
SEM1A_DROMESema-1agenetic
12835384
BICD_DROMEBicDgenetic
20111007
HOOK_DROMEhkgenetic
11018772
STAN_DROMEstangenetic
16326392
GCH1_DROMEPugenetic
17585895
DRONC_DROMENcgenetic
25790850
HSP7D_DROMEHsc70-4genetic
12427870
SH3G3_DROMEEndoAgenetic
14627659
NCASE_DROMECDasegenetic
12637747
NDKA_DROMEawdgenetic
11343655
NDKA_DROMEawdgenetic
12382260
NDKA_DROMEawdgenetic
14630942
NDKA_DROMEawdgenetic
14668379
PRIC1_DROMEpkgenetic
16326392
TTKB_DROMEttkgenetic
23545328
TTKA_DROMEttkgenetic
23545328
SH3G3_DROMEEndoAphysical
24977345
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DYN_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-756; SER-764 ANDSER-767, AND MASS SPECTROMETRY.

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