DRONC_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DRONC_DROME
• UniProt AC: Q9XYF4
• Protein Name: Caspase Dronc
• Gene Name: Dronc {ECO:0000312|FlyBase:FBgn0026404}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 450
• Subcellular Localization: Cytoplasm.
• Protein Description: Involved in the activation cascade of caspases responsible for apoptosis execution. Effector of steroid-mediated apoptosis during insect metamorphosis. Overexpression promotes programmed cell death. Interaction with Diap1 is required to suppress Dronc-mediated cell death; via Diap1-mediated ubiquitination of Dronc. Rate-limiting caspase in rpr and hid death pathway..
• Protein Sequence: MQPPELEIGMPKRHREHIRKNLNILVEWTNYERLAMECVQQGILTVQMLRNTQDLNGKPFNMDEKDVRVEQHRRLLLKITQRGPTAYNLLINALRNINCLDAAVLLESVDESDSRPPFISLNERRTSRKSADIVDTPSPEASEGPCVSKLRNEPLGALTPYVGVVDGPEVKKSKKIHGGDSAILGTYKMQSRFNRGVLLMVNIMDYPDQNRRRIGAEKDSKSLIHLFQELNFTIFPYGNVNQDQFFKLLTMVTSSSYVQNTECFVMVLMTHGNSVEGKEKVEFCDGSVVDMQKIKDHFQTAKCPYLVNKPKVLMFPFCRGDEYDLGHPKNQGNLMEPVYTAQEEKWPDTQTEGIPSPSTNVPSLADTLVCYANTPGYVTHRDLDTGSWYIQKFCQVMADHAHDTDLEDILKKTSEAVGNKRTKKGSMQTGAYDNLGFNKKLYFNPGFFNE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Acetylation	NTQDLNGKPFNMDEK CCCCCCCCCCCCCHH		21791702
130	Phosphorylation	ERRTSRKSADIVDTP CCCCCCCCCCCCCCC		22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Diap1	Q24306	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DRONC_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DRONC_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DIAP1_DROME	th	physical	10675329
LAMA_DROME	LanA	physical	15710747
DIAP1_DROME	th	physical	15710747
F10A1_DROME	HIP-R	physical	22036573
F10A2_DROME	HIP-R	physical	22036573
CASP8_DROME	Dredd	genetic	21120926
SGG_DROME	sgg	genetic	16222340
WNTG_DROME	wg	genetic	16222340
DIAP2_DROME	Iap2	genetic	10984473
CASP1_DROME	Dcp-1	genetic	21120926
DIAP1_DROME	th	genetic	10825159
DIAP1_DROME	th	genetic	10984473
DIAP1_DROME	th	genetic	12021771
DIAP1_DROME	th	genetic	10675329
UBCD1_DROME	eff	genetic	12021769
NUMB_DROME	numb	physical	21558368
MYO7A_DROME	ck	physical	26960254
EIF3M_DROME	Tango7	physical	23913920
DIAP1_DROME	th	physical	15774476
DIAP1_DROME	th	physical	25146930
DRICE_DROME	Ice	physical	23913920
DRICE_DROME	Ice	physical	25644603

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.