| UniProt ID | CASP1_DROME | |
|---|---|---|
| UniProt AC | O02002 | |
| Protein Name | Caspase-1 | |
| Gene Name | Dcp-1 | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 323 | |
| Subcellular Localization | ||
| Protein Description | Involved in the activation cascade of caspases responsible for apoptosis execution (By similarity). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Loss of zygotic DCP-1 function causes larval lethality and melanotic tumors.. | |
| Protein Sequence | MTDECVTRNYGVGIRSPNGSENRGSFIMADNTDAKGCTPESLVVGGATAASPLPANKFVARMPVERYASEYNMSHKHRGVALIFNHEFFDIPSLKSRTGTNVDAQELKKAFENLGFAVSVHKDCKLRDILKHVGKAAELDHTDNDCLAVAILSHGEHGYLYAKDTQYKLDNIWHYFTATFCPSLAGKPKLFFIQACQGDRLDGGITLEKGVTETDGESSTSYKIPIHADFLFSYSTIPGYFSWRNINNGSWYMQSLIRELNANGKKYDLLTLLTFVNQRVALDFESNVPATPMMDRQKQIPCLTSMLTRILRFGDKPNGNKAG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CASP1_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CASP1_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CASP1_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ADT_DROME | sesB | genetic | 24862573 | |
| CYPR_DROME | ninaA | genetic | 19339992 | |
| POK_DROME | aop | genetic | 20100334 | |
| ESCA_DROME | esg | genetic | 20100334 | |
| EGFR_DROME | Egfr | genetic | 20100334 | |
| UBPE_DROME | Ubp64E | genetic | 20100334 | |
| UBCD4_DROME | UbcD4 | genetic | 20100334 | |
| DRONC_DROME | Nc | genetic | 21120926 | |
| DIAP1_DROME | th | genetic | 12885559 | |
| DIAP1_DROME | th | genetic | 15580265 | |
| DIAP1_DROME | th | genetic | 20100334 | |
| E74EB_DROME | Eip74EF | genetic | 20100334 | |
| E74EA_DROME | Eip74EF | genetic | 20100334 | |
| HID_DROME | W | genetic | 10733594 | |
| GRIM_DROME | grim | genetic | 10733594 | |
| RPR_DROME | rpr | genetic | 10619022 | |
| RPR_DROME | rpr | genetic | 10733594 | |
| E78C_DROME | Eip78C | genetic | 20100334 | |
| UBCD1_DROME | eff | genetic | 20100334 | |
| AKT1_DROME | Akt1 | genetic | 20100334 | |
| DL_DROME | Dl | genetic | 20100334 | |
| BECN1_DROME | Atg6 | genetic | 20100334 | |
| FAF_DROME | faf | genetic | 20100334 | |
| BRC1_DROME | br | genetic | 20100334 | |
| BRC4_DROME | br | genetic | 20100334 | |
| TOR_DROME | Tor | genetic | 20100334 | |
| ADT_DROME | sesB | physical | 24862573 | |
| DRICE_DROME | Ice | physical | 24862573 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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