dbPTM

HID_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HID_DROME
UniProt AC	Q24106
Protein Name	Cell death protein hid
Gene Name	hid
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	410
Subcellular Localization
Protein Description	Activator of apoptosis, with grim and rpr, that acts on the effector Dredd. [PubMed: 9740659 Seems to act genetically upstream of baculoviral anti-apoptotic p35]
Protein Sequence	MAVPFYLPEGGADDVASSSSGASGNSSPHNHPLPSSASSSVSSSGVSSASASSASSSSSASSDGASSAASQSPNTTTSSATQTPMQSPLPTDQVLYALYEWVRMYQSQQSAPQIFQYPPPSPSCNFTGGDVFFPHGHPNPNSNPHPRTPRTSVSFSSGEEYNFFRQQQPQPHPSYPAPSTPQPMPPQSAPPMHCSHSYPQQSAHMMPHHSAPFGMGGTYYAGYTPPPTPNTASAGTSSSSAAFGWHGHPHSPFTSTSTPLSAPVAPKMRLQRSQSDAARRKRLTSTGEDEREYQSDHEATWDEFGDRYDNFTAGRERLQEFNGRIPPRKKKSSNSHSSSSNNPVCHTDSQPGGTSQAESGAIHGHISQQRQVERERQKAKAEKKKPQSFTWPTVVTVFVLAMGCGFFAAR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
295	Phosphorylation	EDEREYQSDHEATWD CCHHHHHHHHCCCHH	39.78	18327897

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HID_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HID_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HID_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOL9_DROME	CG8414	physical	14605208
DIAP1_DROME	th	physical	10675328
HR4_DROME	Hr4	genetic	16118195
KRAF1_DROME	phl	genetic	9814703
KRAF1_DROME	phl	genetic	9814704
DSOR1_DROME	Dsor1	genetic	9814703
DSOR1_DROME	Dsor1	genetic	10200472
LOZEN_DROME	lz	genetic	15879554
NETA_DROME	NetA	genetic	23499445
NETB_DROME	NetB	genetic	23499445
SMO_DROME	smo	genetic	23018595
XPO1_DROME	emb	genetic	17953484
KAPC_DROME	Pka-C1	genetic	23018595
COS_DROME	cos	genetic	23018595
PNUT_DROME	pnut	genetic	15029247
VPS25_DROME	Vps25	genetic	16611691
VPS25_DROME	Vps25	genetic	19132102
PTC_DROME	ptc	genetic	23018595
DIAP2_DROME	Iap2	genetic	8548811
DIAP2_DROME	Iap2	genetic	9846179
ACOX1_DROME	CG5009	genetic	17953484
HIPPO_DROME	hpo	genetic	14561774
HIPPO_DROME	hpo	genetic	14502294
HIPPO_DROME	hpo	genetic	14502295
EGFR_DROME	Egfr	genetic	9814703
EGFR_DROME	Egfr	genetic	9814704
YAP1_DROME	yki	genetic	22615583
SPY_DROME	sty	genetic	9814704
RCC1_DROME	Rcc1	genetic	15136144
TRPA1_DROME	TrpA1	genetic	21068723
GAP1_DROME	RasGAP1	genetic	9814704
DRONC_DROME	Nc	genetic	10825159
DRONC_DROME	Nc	genetic	15268856
DRONC_DROME	Nc	genetic	15469838
DRONC_DROME	Nc	genetic	15800001
DRONC_DROME	Nc	genetic	16446367
DRONC_DROME	Nc	genetic	16485033
DRONC_DROME	Nc	genetic	16980627
DRONC_DROME	Nc	genetic	23306653
VPS36_DROME	Vps36	genetic	19132102
DICH_DROME	D	genetic	14668372
DIAP1_DROME	th	genetic	8548811
DIAP1_DROME	th	genetic	10655220
DIAP1_DROME	th	genetic	10675328
DIAP1_DROME	th	genetic	9814704
DIAP1_DROME	th	genetic	11287192
DIAP1_DROME	th	genetic	12021771
GIL_DROME	aos	genetic	9814704
GRIM_DROME	grim	genetic	9846179
RPR_DROME	rpr	genetic	21068723
RPR_DROME	rpr	genetic	20837774
RAS1_DROME	Ras85D	genetic	9814703
RAS1_DROME	Ras85D	genetic	9814704
RAS1_DROME	Ras85D	genetic	21858158
UBCD1_DROME	eff	genetic	12021769
CSN5_DROME	CSN5	genetic	21145488
GLAS_DROME	gl	genetic	9144214
GLAS_DROME	gl	genetic	14668372
CRY1_DROME	cry	genetic	14960620
JMJD6_DROME	PSR	genetic	17522160
MOB1_DROME	mats	genetic	15766530
PNT1_DROME	pnt	genetic	9814703
PNT2_DROME	pnt	genetic	9814703
DRICE_DROME	Ice	genetic	16485033
DRICE_DROME	Ice	genetic	16645642
DRICE_DROME	Ice	genetic	16887831
DRICE_DROME	Ice	genetic	16980627
DRICE_DROME	Ice	genetic	23306653
DRICE_DROME	Ice	genetic	26542461
PANG1_DROME	pan	genetic	15469838
PANG2_DROME	pan	genetic	15469838
WECH_DROME	wech	genetic	17953484
JNK_DROME	bsk	genetic	23306653
SAV_DROME	sav	genetic	12202036
ERKA_DROME	rl	genetic	9814703
ERKA_DROME	rl	genetic	9814704
ERKA_DROME	rl	genetic	11832242
ERKA_DROME	rl	genetic	10200472
DIAP2_DROME	Iap2	physical	16485033
DIAP1_DROME	th	physical	12021769
DIAP1_DROME	th	physical	16485033
DIAP1_DROME	th	physical	20837774
HID_DROME	W	physical	20837774
RPR_DROME	rpr	physical	20837774

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HID_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295, AND MASSSPECTROMETRY.	18327897 [Abstract]