COS_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COS_DROME
• UniProt AC: O16844
• Protein Name: Kinesin-like protein costa
• Gene Name: cos
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1201
• Subcellular Localization: Cytoplasm, cytoskeleton .
• Protein Description: Regulates cubitus interruptus (ci) processing by recruiting multiple kinases to promote its efficient phosphorylation. Scaffolds multiple kinases and ci into proximity to promote its hyperphosphorylation, which then targets it for SCFSlimb/proteasome-mediated processing to generate its repressor form. Hh signaling inhibits ci phosphorylation by interfering with the cos-ci-kinases complex formation. Negatively regulates hh-signaling pathways during various processes, including photoreceptor differentiation. [PubMed: 25639794]
• Protein Sequence: MEIPIQVAVRIFPHRELKDLLRSFGPTEPKKDAQAVDEGADSKDSEAQVPAAEKDNPSISETDPNGNAEQDSAADSKTIPDANGNDSGQKDYPDSAYCVQAIPISASALGLPSALPGGDPMDSIAAGLIQVGPHTVPVTHALPSSSSQEQVYHQTVFPLITLFLEGFDASVVTYGQRGQGKSYTLYGNVQDPTLTDSTEGVVQLCVRDIFSHISLHPERTYAINVGFVEICGGDVCDLLGMGNIHCTNVDAVFHWLQVGLSARQSLPAHTLFTLTLEQQWVSKEGLLQHRLSTASFSDLCGTERCGDQPPGRPLDAGLCMLEQVISTLTDPGLMYGVNGNIPYGQTTLTTLLKDSFGGRAQTLVILCVSPLEEHLPETLGNLQFAFKVQCVRNFVIMNTYSDDNTMIVQPAEPVPESNSSAGPLSQAGPGDNFGLQFAASQWSKLVTNAEGLFSKLIDSKLITEVEKEQIEEWLFLKQECEECLSSTEAMRQQKQLVPILEAEEPEDVNSEAANSESPNSDNENDTDNESHRPDLDDKIESLMEEFRDKTDALILEKHAEYLSKHPKAVMQSQDREIEAQPPEENGDDRKVSIGSRRRSVQPGASLSTAELAMLNRVASQQPPPPIDPESVVDPLESSSGEGIRQAALAAAAATAPIEQLQKKLRKLVAEIEGKQRQLREIEETIQVKQNIIAELVKNSDTRSHAKQRFHKKRAKLEAECDKAKKQLGKALVQGRDQSEIERWTTIIGHLERRLEDLSSMKHIAGESGQKVKKLQQSVGESRKQADDLQKKLRKECKLRCQMEAELAKLRESRETGKELVKAQGSPEQQGRQLKAVQARITHLNHILREKSDNLEEQPGPEQQETLRHEIRNLRGTRDLLLEERCHLDRKLKRDKVLTQKEERKLLECDEAIEAIDAAIEFKNEMITGHRSIDTSDRIQREKGEQMLMARLNRLSTEEMRTLLYKYFTKVIDLRDSSRKLELQLVQLERERDAWEWKERVLSNAVRQARLEGERNAVLLQRQHEMKLTLMLRHMAEETSASSASYGERALAPACVAPPVQASSDFDYDHFYKGGGNPSKALIKAPKPMPTGSALDKYKDKEQRSGRNIFAKFHVLTRYASAAAAGSSGSTAEESTALIESTTTATATTTSTTTTGAVGKVKDKALVSFRPEQLKRLMPAPTATKVTRQKNKIIIQDASRRN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
572	Phosphorylation	HPKAVMQSQDREIEA CCHHHHHCCCCCCCC	18.89	11934882
592	Phosphorylation	NGDDRKVSIGSRRRS CCCCCCEECCCCCCC	25.02	29892262
599	Phosphorylation	SIGSRRRSVQPGASL ECCCCCCCCCCCCCC	24.24	22817900
605	Phosphorylation	RSVQPGASLSTAELA CCCCCCCCCCHHHHH	28.86	22817900
608	Phosphorylation	QPGASLSTAELAMLN CCCCCCCHHHHHHHH	29.46	22817900
825	Phosphorylation	ELVKAQGSPEQQGRQ HHHHHCCCHHHHHHH	17.12	25749252
931	Phosphorylation	EMITGHRSIDTSDRI CHHHCCCCCCCCHHH	21.10	11934882

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
572	S	Phosphorylation	Kinase	FU	P23647	GPS
931	S	Phosphorylation	Kinase	FU	P23647	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COS_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COS_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CI_DROME	ci	physical	9244298
CI_DROME	ci	physical	10825151
FUSED_DROME	fu	physical	10825151
FUSED_DROME	fu	physical	11495917
FUSED_DROME	fu	physical	11839821
CI_DROME	ci	physical	15710747
DICH_DROME	D	physical	15710747
DPOLA_DROME	DNApol-alpha180	physical	15710747
KDC2_DROME	Pka-C3	physical	15710747
FUSED_DROME	fu	physical	22036573
SMO_DROME	smo	genetic	16423832
CI_DROME	ci	genetic	22677792
SGG_DROME	sgg	physical	21852395
KC1A_DROME	CkIalpha	physical	21852395
FUSED_DROME	fu	physical	14636583
FUSED_DROME	fu	physical	14523402
FUSED_DROME	fu	physical	14614827
FUSED_DROME	fu	physical	18987629
FUSED_DROME	fu	physical	25289679
FUSED_DROME	fu	physical	26271100
FUSED_DROME	fu	physical	9244297
FUSED_DROME	fu	physical	15063184
SMO_DROME	smo	physical	14523402
SMO_DROME	smo	physical	14614827
SMO_DROME	smo	physical	14636583
SMO_DROME	smo	physical	17284519
SMO_DROME	smo	physical	25289679
KAPC_DROME	Pka-C1	physical	25289679
COS_DROME	cos	physical	21844892
PTC_DROME	ptc	physical	17284519
SXL_DROME	Sxl	physical	17284519
GNAI_DROME	Galphai	physical	18987629
CI_DROME	ci	physical	14636583
CI_DROME	ci	physical	14523402
CI_DROME	ci	physical	21852395
CI_DROME	ci	physical	26271100
CI_DROME	ci	physical	9244297
CI_DROME	ci	physical	11090136
CI_DROME	ci	physical	15063184
PP4C_DROME	Pp4-19C	physical	19088085

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-599 AND SER-605, ANDMASS SPECTROMETRY.
PubMed: 18327897