GNAI_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GNAI_DROME
• UniProt AC: P20353
• Protein Name: G protein alpha i subunit
• Gene Name: Galphai
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 355
• Subcellular Localization: Cell membrane . Apical cell membrane . Colocalizes with loco and raps/pins at the apical cortex throughout mitosis in neuroblasts.
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Plays a role in glial cell differentiation during embryogenesis; loco, Galphao and the G-protein coupled receptor, moody, are required in the surface glia to achieve effective insulation of the nerve cord..
• Protein Sequence: MGCAVSTARDKEAIERSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQEECEEYRRVVFSNTVQSLMVIIRAMGRLKIEFADPSRTDIARQFFTHASAADEGILLPEIVLLMKKLWADGGVQQSFARSREYQLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVKTTGIIETHFSCKQLHFKLFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIESLKLFDSICNSKWFVETSIILFLNKKDLFEEKIKRSPLTICFPEYTGTNTFEEAANYIRMKFENLNKRKDQKEIYTHLTCATDTNNVKFVFDAVTDVIIKNNLKQIGLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGCAVSTAR ------CCCCCCCCC	14.21	-
3	S-palmitoylation	-----MGCAVSTARD -----CCCCCCCCCC	3.05	-
47	Ubiquitination	LGAGESGKSTIVKQM ECCCCCCCHHHHHEE	54.42	31113955

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GNAI_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GNAI_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GNAI_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MED19_DROME	MED19	physical	14605208
RIC8_DROME	ric8a	physical	16228011
RIC8_DROME	ric8a	physical	16228012
GBB1_DROME	Gbeta13F	physical	11672526
GBB1_DROME	Gbeta13F	physical	16228011
GBB1_DROME	Gbeta13F	physical	16228012
RGS_DROME	loco	physical	15937221

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.