dbPTM

FUSED_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FUSED_DROME
UniProt AC	P23647
Protein Name	Serine/threonine-protein kinase fused
Gene Name	fu
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	805
Subcellular Localization
Protein Description	Probable serine/threonine-protein kinase; maternally required for correct patterning in the posterior part of each embryonic metamere. May be involved in control of cell division during metamorphosis and ovarian development. May interact with costal-2..
Protein Sequence	MNRYAVSSLVGQGSFGCVYKATRKDDSKVVAIKVISKRGRATKELKNLRRECDIQARLKHPHVIEMIESFESKTDLFVVTEFALMDLHRYLSYNGAMGEEPARRVTGHLVSALYYLHSNRILHRDLKPQNVLLDKNMHAKLCDFGLARNMTLGTHVLTSIKGTPLYMAPELLAEQPYDHHADMWSLGCIAYESMAGQPPFCASSILHLVKMIKHEDVKWPSTLTSECRSFLQGLLEKDPGLRISWTQLLCHPFVEGRIFIAETQAEAAKESPFTNPEAKVKSSKQSDPEVGDLDEALAALDFGESRQENLTTSRDSINAIAPSDVEHLETDVEDNMQRVVVPFADLSYRDLSGVRAMPMVHQPVINSHTCFVSGNSNMILNHMNDNFDFQASLRGGGVAAKPIVAPTVRQSRSKDLEKRKLSQNLDNFSVRLGHSVDHEAQRKATEIATQEKHNQENKPPAEAISYANSQPPQQQPQQLKHSMHSTNEEKLSSDNTPPCLLPGWDSCDESQSPPIENDEWLAFLNRSVQELLDGELDSLKQHNLVSIIVAPLRNSKAIPRVLKSVAQLLSLPFVLVDPVLIVDLELIRNVYVDVKLVPNLMYACKLLLSHKQLSDSAASAPLTTGSLSRTLRSIPELTVEELETACSLYELVCHLVHLQQQFLTQFCDAVAILAASDLFLNFLTHDFRQSDSDAASVRLAGCMLALMGCVLRELPENAELVERIVFNPRLNFVSLLQSRHHLLRQRSCQLLRLLARFSLRGVQRIWNGELRFALQQLSEHHSYPALRGEAAQTLDEISHFTFFVT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
154	Phosphorylation	ARNMTLGTHVLTSIK CCCCCCCCHHHHCCC	16.36	21082442
158	Phosphorylation	TLGTHVLTSIKGTPL CCCCHHHHCCCCCCC	27.58	11495917
159	Phosphorylation	LGTHVLTSIKGTPLY CCCHHHHCCCCCCCC	20.38	11495917
347	Phosphorylation	VVPFADLSYRDLSGV EEECCCCCCCCCCCC	20.76	21082442
401	Acetylation	RGGGVAAKPIVAPTV CCCCCCCCCEECCCC	26.07	21791702
422	Phosphorylation	DLEKRKLSQNLDNFS HHHHHHHHHCCCHHH	21.76	19429919
429	Phosphorylation	SQNLDNFSVRLGHSV HHCCCHHHHHCCCCC	16.75	8307322
435	Phosphorylation	FSVRLGHSVDHEAQR HHHHCCCCCCHHHHH	27.69	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FUSED_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FUSED_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FUSED_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CI_DROME	ci	physical	10825151
COS_DROME	cos	physical	10825151
COS_DROME	cos	physical	11495917
COS_DROME	cos	physical	11839821
COS_DROME	cos	physical	15710747
Y2138_DROME	CG32138	physical	15710747
MIRO_DROME	Miro	physical	15710747
VIP1_DROME	l(1)G0196	physical	15710747
IPOU_DROME	acj6	physical	15710747
TBA1_DROME	alphaTub84B	physical	15710747
IDH3A_DROME	l(1)G0156	physical	15710747
TNKS_DROME	Tnks	physical	15710747
FLOT1_DROME	Flo1	physical	15710747
HH_DROME	hh	physical	15710747
SDA1_DROME	Mys45A	physical	15710747
TENM_DROME	Ten-m	physical	15710747
VATG_DROME	Vha13	physical	15710747
KAPR2_DROME	Pka-R2	physical	22036573
SMO_DROME	smo	genetic	17658259
COS_DROME	cos	genetic	12163413
HH_DROME	hh	genetic	10704398
CI_DROME	ci	genetic	9858670
CI_DROME	ci	genetic	12163413
COLL_DROME	kn	genetic	10375526
FUSED_DROME	fu	physical	21844892
FUSED_DROME	fu	physical	21852395
SMO_DROME	smo	physical	25289679
SMO_DROME	smo	physical	17182028
KAPC_DROME	Pka-C1	physical	25289679
COS_DROME	cos	physical	9244297
COS_DROME	cos	physical	21852395
COS_DROME	cos	physical	25289679
COS_DROME	cos	physical	21844892
SMUF1_DROME	lack	physical	21145463
CI_DROME	ci	physical	9244297
CI_DROME	ci	physical	14611647
CI_DROME	ci	physical	9601642

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FUSED_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-422 AND SER-429, ANDMASS SPECTROMETRY.	18327897 [Abstract]