SDA1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SDA1_DROME
• UniProt AC: Q7KKH3
• Protein Name: Protein SDA1 homolog
• Gene Name: Mys45A
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 712
• Subcellular Localization: Nucleus, nucleolus.
• Protein Description: Required for 60S pre-ribosomal subunits export to the cytoplasm..
• Protein Sequence: MVRPNNNQLPENLPQLQNLIKRDPESYSDEFHIQYQHFLSLLEVFALNPSEENKSLDDIVMFVAQVAQCYPAVCEEFPKRLSDLLKNYATVLDPAMRNCFVKALILLRNKNLVPALDILELFFQLLRCPDKNLRTFLQTHIVTDIKNMNAKHKDMKLNSSLQAFMYSMLKDANPKAAKMSADIMIELYKKNIWNDSKTVNVIATVGCFSKVTKVLVTSLKFFLGHDEEDEEEDTDSENEVDLKGALMANRVNKKTKKRTKQLAQIKKQAVKAQKKKKNAPAFNFSGIHLVHNPQGMAEGLFKQLQATNERFEVKLMHLDVISRLIGIHDLFLFGFYPYITRFLQPHQRQVTRVLQFAAQASHELVPGDIIEPILKTIANNFITERNSSDVMAIGLNATREICMRCPLAMGEDLLQDLAMYKTYKEKSVMMAARSLITLYREQLPALLHKKDRGRQTEAQAERKVRAYGEREVHDTVLGAEALLKDSKTIDIESEDDTDSNDGEWVNVAHSDGEGGGADDDEEDEDEDEDDDDEDEDEENSNDEENEDEDNSDEGVESGEESAKAKKEKKDMRILNQKEAAQELALTRIFTDEDFKRINAANLKKTVTSARKRPLEQDRAEFVKLNSIEMIYKKRKHDKESRLETVQAGRQDRERFGWKDGRVNEHCSKTNREKRKTKNFGMLRHKARSKVKKSFKDKQQALRKHLLHQKKMK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
234	Phosphorylation	EEDEEEDTDSENEVD CCCCCCCCCCCCCCC	44.71	19429919
236	Phosphorylation	DEEEDTDSENEVDLK CCCCCCCCCCCCCHH	44.40	19429919
422	Phosphorylation	QDLAMYKTYKEKSVM HHHHHHHHHHHHHHH	23.49	22817900
423	Phosphorylation	DLAMYKTYKEKSVMM HHHHHHHHHHHHHHH	17.01	22817900
626	Phosphorylation	AEFVKLNSIEMIYKK HHHHHHHHHHHHHHH	30.29	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SDA1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SDA1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SDA1_DROME !!

Protein-Protein Interaction

Oops, there are no PPI records of SDA1_DROME !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-234 AND SER-236, ANDMASS SPECTROMETRY.
PubMed: 18327897