KAPR2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KAPR2_DROME
• UniProt AC: P81900
• Protein Name: cAMP-dependent protein kinase type II regulatory subunit
• Gene Name: Pka-R2
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 377
• Subcellular Localization: Cytoplasm .
• Protein Description: Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. The regulatory subunit may play an essential role in the regulation of neuronal activity in the brain. Has a role in circadian locomotor rhythm, and behavioral response to cocaine and ethanol..
• Protein Sequence: MSSDSSRRIQVPEELKEVLLQFSISFLVEQPPDVIDYAVEYFTKLQSERPSVSHTDQSTDDQLSVNSQDADAEPPVMASSRRKSVFAEAYDPEADDDDDGATAVFPKTDEQRARLVESVKNVLLFRSLEKEQMNQVLDAMFERKVQPGDFIIRQGDDGDNFYVIESGVYKVYINDKHINTYNHTGLFGELALLYNMPRAATVQAETSGLLWAMDRQTFRRILLKSAFRKRKMYEELLNSVPMLKALQNYERMNLADALVSKSYDNGERIIKQGDAADGMYFIEEGTVSVRMDQDDAEVEISQLGKGQYFGELALVTHRPRAASVYATGGVVKLAFLDVKAFERLLGPCMDIMKRNIDDYESQLVKIFGSKNNITDTR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSDSSRRI ------CCCCCCCCC	42.74	27794539
3	Phosphorylation	-----MSSDSSRRIQ -----CCCCCCCCCC	39.97	27794539
5	Phosphorylation	---MSSDSSRRIQVP ---CCCCCCCCCCCC	27.91	27794539
6	Phosphorylation	--MSSDSSRRIQVPE --CCCCCCCCCCCCH	30.48	27794539
51	Phosphorylation	KLQSERPSVSHTDQS HHHHCCCCCCCCCCC	42.34	22817900
55	Phosphorylation	ERPSVSHTDQSTDDQ CCCCCCCCCCCCCCC	28.38	23607784
58	Phosphorylation	SVSHTDQSTDDQLSV CCCCCCCCCCCCCCC	36.29	23607784
59	Phosphorylation	VSHTDQSTDDQLSVN CCCCCCCCCCCCCCC	37.65	23607784
64	Phosphorylation	QSTDDQLSVNSQDAD CCCCCCCCCCCCCCC	17.39	23607784
67	Phosphorylation	DDQLSVNSQDADAEP CCCCCCCCCCCCCCC	27.55	23607784
84	Phosphorylation	MASSRRKSVFAEAYD CCCHHHCEEEEEECC	22.21	19429919
90	Phosphorylation	KSVFAEAYDPEADDD CEEEEEECCCCCCCC	24.44	19060867
323	Phosphorylation	THRPRAASVYATGGV ECCCCCEEEEECCCE	18.06	27794539
369	Phosphorylation	QLVKIFGSKNNITDT HHHHHHCCCCCCCCC	22.82	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KAPR2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KAPR2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KAPR2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAF11_DROME	Taf11	physical	14605208
ER_DROME	e(r)	physical	14605208
CCNE_DROME	CycE	genetic	12242236

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51; SER-58; SER-64;SER-67; SER-84 AND TYR-90, AND MASS SPECTROMETRY.
PubMed: 18327897