TBA1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBA1_DROME
• UniProt AC: P06603
• Protein Name: Tubulin alpha-1 chain
• Gene Name: alphaTub84B
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 450
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain..
• Protein Sequence: MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTVGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLADQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGMDSGDGEGEGAEEY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Acetylation	DGQMPSDKTVGGGDD CCCCCCCCCCCCCCC	49.82	-
48	Phosphorylation	TVGGGDDSFNTFFSE CCCCCCCCHHHCCCC	25.74	19429919
51	Phosphorylation	GGDDSFNTFFSETGA CCCCCHHHCCCCCCC	24.85	22817900
96	Ubiquitination	PEQLITGKEDAANNY HHHHCCCCHHHHHHC	43.71	31113955
112	Acetylation	RGHYTIGKEIVDLVL CCCCCCCHHHHHHHH	40.18	21791702
163	Acetylation	RLSVDYGKKSKLEFA HHCCCCCCCCCEEEE	47.87	21791702
277	Phosphorylation	VTYAPVISAEKAYHE EEECCCCCHHHHHHH	30.52	22817900
282	Phosphorylation	VISAEKAYHEQLSVA CCCHHHHHHHHCCHH	19.56	21082442
287	Phosphorylation	KAYHEQLSVAEITNA HHHHHHCCHHHHHHH	20.98	21082442
326	Acetylation	YRGDVVPKDVNAAIA CCCCCCCCCCCHHHH	63.80	21791702
394	Acetylation	AWARLDHKFDLMYAK HHHHCCCCCCHHHEE	39.99	21791702
401	Acetylation	KFDLMYAKRAFVHWY CCCHHHEEEHHHHHH	27.11	21791702
439	Phosphorylation	YEEVGMDSGDGEGEG HHHHCCCCCCCCCCC	29.86	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBA1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBA1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBA1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SAV_DROME	sav	physical	14605208
ATRIP_DROME	mus304	physical	14605208
CDKAL_DROME	CG6550	physical	22036573
RS27A_DROME	RpS27A	physical	24292889
KLP68_DROME	Klp68D	physical	27976831

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.