dbPTM

DIAP2_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DIAP2_DROME
UniProt AC	Q24307
Protein Name	Death-associated inhibitor of apoptosis 2
Gene Name	Diap2
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	498
Subcellular Localization	Nucleus . Cytoplasm .
Protein Description	Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. [PubMed: 16894030]
Protein Sequence	MTELGMELESVRLATFGEWPLNAPVSAEDLVANGFFATGNWLEAECHFCHVRIDRWEYGDQVAERHRRSSPICSMVLAPNHCGNVPRSQESDNEGNSVVDSPESCSCPDLLLEANRLVTFKDWPNPNITPQALAKAGFYYLNRLDHVKCVWCNGVIAKWEKNDNAFEEHKRFFPQCPRVQMGPLIEFATGKNLDELGIQPTTLPLRPKYACVDARLRTFTDWPISNIQPASALAQAGLYYQKIGDQVRCFHCNIGLRSWQKEDEPWFEHAKWSPKCQFVLLAKGPAYVSEVLATTAANASSQPATAPAPTLQADVLMDEAPAKEALALGIDGGVVRNAIQRKLLSSGCAFSTLDELLHDIFDDAGAGAALEVREPPEPSAPFIEPCQATTSKAASVPIPVADSIPAKPQAAEAVANISKITDEIQKMSVATPNGNLSLEEENRQLKDARLCKVCLDEEVGVVFLPCGHLATCNQCAPSVANCPMCRADIKGFVRTFLS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of DIAP2_DROME !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DIAP2_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DIAP2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DIAP2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DIAP1_DROME	th	physical	17205079
HEM6_DROME	Coprox	physical	22036573
LARP_DROME	larp	physical	23749869
DPY30_DROME	Dpy-30L1	physical	23749869
RS17_DROME	RpS17	physical	23749869
RL7A_DROME	RpL7A	physical	23749869
DIAP2_DROME	Iap2	physical	23749869
SRP_DROME	srp	physical	23749869
CP190_DROME	Cp190	physical	23749869
CREBB_DROME	CrebB	physical	23749869
ISWI_DROME	Iswi	physical	23749869
MOC2B_DROME	Mocs2	physical	23749869
TAF6_DROME	Taf6	physical	23749869
CATL_DROME	Cp1	physical	23749869
MA205_DROME	Map205	physical	23749869
ANKHM_DROME	mask	physical	23749869
VRET_DROME	vret	physical	23749869
EF1A1_DROME	Ef1alpha48D	physical	23749869
ANLN_DROME	scra	physical	23749869
EF1A2_DROME	Ef1alpha100E	physical	23749869
ZASP_DROME	Zasp52	physical	23749869
HSP7E_DROME	Hsc70-5	physical	23749869
S39AD_DROME	Zip99C	physical	23749869
CUP_DROME	cup	physical	23749869
LIG_DROME	lig	physical	23749869
RL22_DROME	RpL22	physical	23749869
TBA2_DROME	alphaTub85E	physical	23749869
PRDX1_DROME	Jafrac1	physical	23749869
EF2_DROME	EF2	physical	23749869
TCPG_DROME	Cctgamma	physical	23749869
TBA3_DROME	alphaTub84D	physical	23749869
TBA1_DROME	alphaTub84B	physical	23749869
IF2A_DROME	eIF-2alpha	physical	23749869
CADF_DROME	tsr	physical	23749869
RS28_DROME	RpS28b	physical	23749869
SODC_DROME	Sod	physical	23749869
ADT_DROME	sesB	physical	23749869
HCF_DROME	Hcf	physical	23749869
RS16_DROME	RpS16	physical	23749869
RS3_DROME	RpS3	physical	23749869
JUPIT_DROME	Jupiter	physical	23749869
ATPA_DROME	blw	physical	23749869
STIM_DROME	Stim	physical	23749869
RS20_DROME	RpS20	physical	23749869
CH60_DROME	Hsp60	physical	23749869
RUVB1_DROME	pont	physical	23749869
ATC1_DROME	Ca-P60A	physical	23749869
HCD2_DROME	scu	physical	23749869
Y3800_DROME	CG3800	physical	23749869
TBB1_DROME	betaTub56D	physical	23749869
SOYB_DROME	SoYb	physical	23749869
HSP7D_DROME	Hsc70-4	physical	23749869
HRS_DROME	Hrs	physical	23749869
PUM_DROME	pum	physical	23749869
EIF2A_DROME	CG7414	physical	23749869
CACT_DROME	cact	physical	23749869
GGYF1_DROME	CG11148	physical	23749869
BAP60_DROME	Bap60	physical	23749869
SMD2_DROME	SmD2	physical	23749869
LVA_DROME	lva	physical	23749869
EAF3_DROME	MRG15	physical	23749869
NCD_DROME	ncd	physical	23749869
FOSLD_DROME	kay	physical	23749869
FOSLA_DROME	kay	physical	23749869
NU153_DROME	Nup153	physical	23749869
TCPA_DROME	T-cp1	physical	23749869
RL24_DROME	RpL24	physical	23749869
TBB3_DROME	betaTub60D	physical	23749869
RING1_DROME	Sce	physical	23749869
CTBP_DROME	CtBP	physical	23749869
SLE_DROME	sle	physical	23749869
GBLP_DROME	Rack1	physical	23749869
HSP7A_DROME	Hsc70-1	physical	23749869
SLEL_DROME	CG12592	physical	23749869
DCTN2_DROME	Dmn	physical	23749869
LIN54_DROME	mip120	physical	23749869
DOM_DROME	dom	physical	23749869
CDV3_DROME	CG3760	physical	23749869
OTE_DROME	Ote	physical	23749869
NH2L1_DROME	hoip	physical	23749869
Y2138_DROME	CG32138	physical	23749869
TAF4_DROME	Taf4	physical	23749869
CH60C_DROME	Hsp60C	physical	23749869
CATA_DROME	Cat	physical	23749869
RUVB2_DROME	rept	physical	23749869
CASP8_DROME	Dredd	physical	25968339
PGPLC_DROME	PGRP-LC	physical	27548432
HID_DROME	W	physical	16485033
DRICE_DROME	Ice	physical	16485033

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DIAP2_DROME

Related Literatures of Post-Translational Modification