NU153_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NU153_DROME
• UniProt AC: Q9VXE6
• Protein Name: Nuclear pore complex protein Nup153
• Gene Name: Nup153
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1883
• Subcellular Localization: Nucleus . Nucleus membrane . Nucleus, nuclear pore complex . Chromosome . Cytoplasm, cytoskeleton, spindle . Localized to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket (
• Protein Description: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. [PubMed: 17682050 Functions as a scaffolding element in the nuclear phase of the NPC]
• Protein Sequence: MEDAQEQRESSQAELAKKHPLTPLKELPEESEEEEEEEDESSAGALRESDSNNSIMGKMKMRVSSILPASLSGWFSPSSKDGNDALSSPANLRQSQPRQSNGRLTTKRKRGRRRIMLAEVDADAADDLDDGSDAKGLNYEEVALADNIAEHDLAAEDEQTRRSEYNVFLLRKRAGAVAAAGGDEDEAEEDELEEDDEDGDEEDDDEEQENLQQSAAVQTKRRRLELETPVNLPNMRRLPLLSSTPAAPLAAATSSSSSQMYKGVSHIAPHRRNHLNLYGSQRQREPAYNFFTGNEAAEGSTGDLPHSIRRSLNIPFGGSSTATSYNNSLSSLPNHKRPSLIGKQTHRRDLTMDETGTGPAMSSEEHLNHLLRISRTNNNTSNNNNNNNNNNNVIETKTRRSELSAAAGGCGDSQSESDMNEYHDNGEGHDGLRPSHYNSNSNLEFYGNLQSSKSIFNRSNTAAQQSHRNSTWSLNSLTQRRRFNASIYGSTSALSDSRLLSGSASNSGSASASSSPFYQGRTTFGGNSGNNRLFSRSNLSSSAASSMLGLNSAGSSPAHQLHASMTGGIGYGMKAVDMRPSDSGSLAETSVGQGGSKKPGTGLSNTTMRILNLLESYSTPLIDAKRMGSSIKEHQSSRQQRQGTPATPYLRSTSASRNVSVPNHINELAELRSNKLLVPTMQQLLERRRLHRVTQNSRDVVHSQNVRAGGENNQEKPKPTAPYVAPIDQSANHTQHTNKMRSRLSHQTRNKETRTAEEEAPPPLDLPQISFPDMASAPKFDLIIKPTVPVVSKPSTTDPIQSSKSSNTNLSTTNSKQMPNFLANPQPAAPIVNFAANGNVSAISKPSKRTFTFSEPTPLSNFQENCIPKPKINRKYTFSAPAPLDDLRITNKQSQPTINGTPSSKEWECDTCMVRNKPEINKCVACETAKPVASAAPVQAPLPPSTAAIDTQSFVGFGDRFKKSTTAWECDACMLSNKAEASKCIACETPRKTVAPKVNNFSPLITNAKSNEWECSVCLVRNKVEVSKCVACESAKPGATMALPATSNIAVATPSIITDGFGDRFKKSATAWECDACMLSNKAEASKCIACETPRKSSTPIANSSYPSINNNLPAGSGFDISFTRKANMWECQTCLVMNKSSDEECIACQTPNSQARNSNSESALISSISSSSASFSGSLSRPSSRSSSGSTSTCGSVCSGSIVSISSTTESAKALSAKKVPPKPDAGFQQLVAAQKTSTWECEACLAKNDMSRKTCICCEQMMPEAFNPAATTANSAASSVPKFRFGFSHVKEVVKPSVETTTTPAPTSAQFSFGFGQSNQGKDVADSKKTEAPKTFMFGVSKVEEPKTVSFGTGIKETTATSSTEATAPTPAAAAPAPVQFVFKAPTTATTASSLTTTISTTSNAPALGGFSFGAPSSSSTVSSSTTSTSANPAAVKPMFSWSGAGSAVSSTSSSQQPVAKAPTLGFGVSSSTVTTTTTSTKVFAFTPASGLDPAAATSAPAAGAGFSFGSQSKPATTQNTGTFFFGQPTAVAPATPTNPSVSSIFGAPATSTTASTSVSATTSTSTANAIASSFAPTSTPQLFGNWGEKKTDLTTFGASSGSGTTTTPSFGWSSNGDAAKSNSAAVGSAAVPSSSASTMATPIFGSSSMFGPSSSSNNTTSTSTTSLPFGSAATTAATTPAGGNAALTGLFGNVGNSLAGVGAPVATTPAATAAAPLTNIFGNPTPVAAAAPVFGSGSTIPSAGFGAPAAAAPLAAPALPGAFNFGGATAATPAASSAPFVFGSSTNEPLAKPSFNFTGSAASSTAPAPAFNFTANTAATNNPSGGDSTPNANALFQFSATSTAPANIFAFNPPAAGNSAQSSQTARRKIRAPVRRLPPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	LAKKHPLTPLKELPE HHHHCCCCCHHHCCC		19429919
31	Phosphorylation	LKELPEESEEEEEEE HHHCCCCCHHHHHHH		19429919
41	Phosphorylation	EEEEEDESSAGALRE HHHHHCCCHHHHHHC		22817900
42	Phosphorylation	EEEEDESSAGALRES HHHHCCCHHHHHHCC		22817900
54	Phosphorylation	RESDSNNSIMGKMKM HCCCCCCCHHCCHHH		30478224
78	Phosphorylation	LSGWFSPSSKDGNDA HHCCCCCCCCCCCCC		21082442
87	Phosphorylation	KDGNDALSSPANLRQ CCCCCCCCCCCHHHC		19429919
88	Phosphorylation	DGNDALSSPANLRQS CCCCCCCCCCHHHCC		19429919
163	Phosphorylation	EDEQTRRSEYNVFLL CCHHHHHHHHHHHHH		19429919
228	Phosphorylation	RRRLELETPVNLPNM HHHHHCCCCCCCCCC		22817900
280	Phosphorylation	NHLNLYGSQRQREPA CCHHCCCCHHCCCCC		21082442
311	Phosphorylation	LPHSIRRSLNIPFGG CCHHHHHHCCCCCCC		21082442
355	Phosphorylation	RDLTMDETGTGPAMS CCCCCCCCCCCCCCC		19429919
357	Phosphorylation	LTMDETGTGPAMSSE CCCCCCCCCCCCCCH		19429919
362	Phosphorylation	TGTGPAMSSEEHLNH CCCCCCCCCHHHHHH		19429919
363	Phosphorylation	GTGPAMSSEEHLNHL CCCCCCCCHHHHHHH		19429919
454	Phosphorylation	GNLQSSKSIFNRSNT CCCHHHHHHHCCCCH		22817900
470	Phosphorylation	AQQSHRNSTWSLNSL HHHHHHCCCCCHHHH		23607784
471	Phosphorylation	QQSHRNSTWSLNSLT HHHHHCCCCCHHHHH		23607784
473	Phosphorylation	SHRNSTWSLNSLTQR HHHCCCCCHHHHHHH		19429919
476	Phosphorylation	NSTWSLNSLTQRRRF CCCCCHHHHHHHHCC		19429919
478	Phosphorylation	TWSLNSLTQRRRFNA CCCHHHHHHHHCCCC		19429919
490	Phosphorylation	FNASIYGSTSALSDS CCCCHHCCCCCCCCC		21082442
492	Phosphorylation	ASIYGSTSALSDSRL CCHHCCCCCCCCCCC		25749252
495	Phosphorylation	YGSTSALSDSRLLSG HCCCCCCCCCCCCCC		27626673
515	Phosphorylation	GSASASSSPFYQGRT CCCCCCCCCCCCCCC		30478224
644	Phosphorylation	SRQQRQGTPATPYLR HHHHHCCCCCCHHHC		19429919
647	Phosphorylation	QRQGTPATPYLRSTS HHCCCCCCHHHCCCC		19429919
649	Phosphorylation	QGTPATPYLRSTSAS CCCCCCHHHCCCCCC		25749252
660	Phosphorylation	TSASRNVSVPNHINE CCCCCCCCCCCHHHH		21082442
1002	Phosphorylation	APKVNNFSPLITNAK CCCCCCCCCCCCCCC		19429919
1099	Phosphorylation	ETPRKSSTPIANSSY CCCCCCCCCCCCCCC		27794539
1290	Phosphorylation	PKFRFGFSHVKEVVK CCCCCCCCCCEECCC		19429919
1305	Phosphorylation	PSVETTTTPAPTSAQ CCCCCCCCCCCCCEE		21082442
1309	Phosphorylation	TTTTPAPTSAQFSFG CCCCCCCCCEEEEEC		21082442
1343	Phosphorylation	KTFMFGVSKVEEPKT CEEEECCCCCCCCCE		19429919
1372	Phosphorylation	STEATAPTPAAAAPA CCCCCCCCCCCCCCC		21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NU153_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NU153_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NU153_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TIM_DROME	tim	physical	25674790

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.