EIF2A_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EIF2A_DROME
• UniProt AC: Q9VNX8
• Protein Name: Eukaryotic translation initiation factor 2A
• Gene Name: CG7414
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 638
• Protein Description: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner..
• Protein Sequence: MAAAADLVVPTLAIRSSVAVELWSSAGSKQPFEHKPHLPREETKSSRSICFSSNGRYFAYSNGQEVKVLQASRDSAASWPVICVLPRPKAFYLQFSPRGSYLCTWEHYAITKDRPEGSPNLLVYEVATGVEVFAIVQKNQADWQPSWSADESIFALVVGGEALFYDLGEGAEKGFATTSRKIGGSRGGMLSLGPGNCPPFLAFYTPGAKGAPSMCKLYKYPALGQNQTVACKSFFQADRVEMLWNKRGSGLLLLTSTEVDKSGASYYGNQAVHFMATKGDTCSVPLSKEGPVHCVKWSPKATEFVVVYGFMPSKAALYNLKCDVVFDFGEGPRNCAYFNPFGNLIALAGFGNLPGAVEVWDVSKREKLANLKCADTTVFEWHPNGEWFVTATTAPRLRISNGFKVYHYSGALLHETMWPQGQELLGIEWQQFADKTFSEPKITKAKHEGIKSSQPEASKKAYTPPHLRLLKEGKNPEKYLPQPSIPGLAPTAAAGGVNGNKRNNKNKQRSARKDVNVVNGGDADSAPTEVVDQAAPVARQSPVFVAAEERKPQHTPRQKYQPDNAADQPPNSYGQGHPNGQHISDKERKIRSVAKKLSDIKKLKVRRSQGENLELNQLNKIKMEAQYLDELKALKQSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
266	Phosphorylation	VDKSGASYYGNQAVH ECCCCCCCCCCEEEE	18.17	18281928
462	Phosphorylation	PEASKKAYTPPHLRL CHHHHHCCCCHHHHH	28.76	19429919
463	Phosphorylation	EASKKAYTPPHLRLL HHHHHCCCCHHHHHH	34.89	19429919
479	Phosphorylation	EGKNPEKYLPQPSIP CCCCHHHCCCCCCCC	23.19	21082442
484	Phosphorylation	EKYLPQPSIPGLAPT HHCCCCCCCCCCCCC	35.85	21082442
541	Phosphorylation	AAPVARQSPVFVAAE CCCHHHCCCEEEEEE	19.92	19429919
608	Phosphorylation	KKLKVRRSQGENLEL HHHHHHHHCCCCCCH	31.79	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EIF2A_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EIF2A_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EIF2A_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-463, AND MASSSPECTROMETRY.
PubMed: 18327897